Emerging role of transient receptor potential (TRP) channels in cancer progression
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Transient receptor potential (TRP) channels comprise a diverse family of ion channels, the majority of which are calcium permeable and show sophisticated regulatory patterns in response to various environmental cues. Early studies led to the recognition of TRP channels as environmental and chemical sensors. Later studies revealed that TRP channels mediated the regulation of intracellular calcium. Mutations in TRP channel genes result in abnormal regulation of TRP channel function or expression, and interfere with normal spatial and temporal patterns of intracellular local Ca2+ distribution. The resulting dysregulation of multiple downstream effectors, depending on Ca2+ homeostasis, is associated with hallmarks of cancer pathophysiology, including enhanced proliferation, survival and invasion of cancer cells. These findings indicate that TRP channels affect multiple events that control cellular fate and play a key role in cancer progression. This review discusses the accumulating evidence supporting the role of TRP channels in tumorigenesis, with emphasis on prostate cancer.
Abstract
Transient receptor potential (TRP) channels comprise a diverse family of ion channels, the majority of which are calcium permeable and show sophisticated regulatory patterns in response to various environmental cues. Early studies led to the recognition of TRP channels as environmental and chemical sensors. Later studies revealed that TRP channels mediated the regulation of intracellular calcium. Mutations in TRP channel genes result in abnormal regulation of TRP channel function or expression, and interfere with normal spatial and temporal patterns of intracellular local Ca2+ distribution. The resulting dysregulation of multiple downstream effectors, depending on Ca2+ homeostasis, is associated with hallmarks of cancer pathophysiology, including enhanced proliferation, survival and invasion of cancer cells. These findings indicate that TRP channels affect multiple events that control cellular fate and play a key role in cancer progression. This review discusses the accumulating evidence supporting the role of TRP channels in tumorigenesis, with emphasis on prostate cancer.
참고문헌 (101)
- Costa-Pereira AP, "Molecular and cellular biology of prostate cancer-the role of apoptosis as a target for therapy", Prostate Cancer Prostatic Dis, 2, pp.126~139 (1999)
- Tapia-Vieyra JV, "Apoptosis and cell death channels in prostate cancer", Arch Med Res, 32, pp.175~185 (2001)
- Wertz IE, "Characterization of calcium release-activated apoptosis of LNCaP prostate cancer cells", J Biol Chem, 275, pp.11470~11477 (2000)
- Xue W, "Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas", Nature, 445, pp.656~660 (2007)
- Fels B, "The Role of TRP Channels in the Metastatic Cascade", Pharmaceuticals (Basel), 11, pp.48~ (2018)
- Berridge MJ, "The versatility and universality of calcium signalling", Nat Rev Mol Cell Biol, 1, pp.11~21 (2000)
- Clapham DE, "Calcium signaling", Cell, 80, pp.259~268 (1995)
- Csordas G, "Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface", Mol Cell, 39, pp.121~132 (2010)
- Baudouin-Legros M, "Effect of ouabain on CFTR gene expression in human Calu-3 cells", Am J Physiol Cell Physiol, 284, pp.C620~626 (2003)
- McConkey DJ, "The role of calcium in the regulation of apoptosis", Biochem Biophys Res Commun, 239, pp.357~366 (1997)
- Parekh AB, "Decoding cytosolic Ca2+ oscillations", Trends Biochem Sci, 36, pp.78~87 (2011)
- Berridge MJ, "The AM and FM of calcium signalling", Nature, 386, pp.759~760 (1997)
- Smedler E, "Frequency decoding of calcium oscillations", Biochim Biophys Acta, 1840, pp.964~969 (2014)
- Cullen PJ, "Calcium signalling : the ups and downs of protein kinase C", Curr Biol, 13, pp.R699~701 (2003)
- (i)oscillation frequency regulates agonist-stimulated NF-kappaB transcriptional activity, "J Biol Chem", 1999, 33995~33998
- Zeng X, "Novel role for the transient receptor potential channel TRPM2 in prostate cancer cell proliferation", Prostate Cancer Prostatic Dis, 13, pp.195~201 (2010)
- Bidaux G, "Regulation of activity of transient receptor potential melastatin 8(TRPM8)channel by its short isoforms", J Biol Chem, 287, pp.2948~2962 (2012)
- Bidaux G, "Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner", Proc Natl Acad Sci U S A, 112, pp.E3345~3354 (2015)
- Patapoutian A, "Transient receptor potential channels : targeting pain at the source", Nat Rev Drug Discov, 8, pp.55~68 (2009)
- Prevarskaya N, "TRP channels in cancer", Biochim Biophys Acta, 1772, pp.937~946 (2007)
- Gkika D, "Molecular mechanisms of TRP regulation in tumor growth and metastasis", Biochim Biophys Acta, 1793, pp.953~958 (2009)
- Santoni G, "TRPV channels in tumor growth and progression", Adv Exp Med Biol, 704, pp.947~967 (2011)
- Talmadge JE, "AACR centennial series : the biology of cancer metastasis : historical perspective", Cancer Res, 70, pp.5649~5669 (2010)
- Hanahan D, "Hallmarks of cancer : the next generation", Cell, 144, pp.646~674 (2011)
- Cosens DJ, "Abnormal electroretinogram from a Drosophila mutant", Nature, 224, pp.285~287 (1969)
- Yoshida T, "Nitric oxide activates TRP channels by cysteine S-nitrosylation", Nat Chem Biol, 2, pp.596~607 (2006)
- Rizza S, "Role, targets and regulation of(de)nitrosylation in Malignancy", Front Oncol, 8, pp.334~ (2018)
- Goel M, "Selective association of TRPC channel subunits in rat brain synaptosomes", J Biol Chem, 277, pp.48303~48310 (2002)
- Hofmann T, "Subunit composition of mammalian transient receptor potential channels in living cells", Proc Natl Acad Sci U S A, 99, pp.7461~7466 (2002)
- Schaefer M, "Homo-and heteromeric assembly of TRP channel subunits", Pflugers Arch, 451, pp.35~42 (2005)
- Strubing C, "Formation of novel TRPC channels by complex subunit interactions in embryonic brain", J Biol Chem, 278, pp.39014~39019 (2003)
- Strubing C, "TRPC1 and TRPC5 form a novel cation channel in mammalian brain", Neuron, 29, pp.645~655 (2001)
- Liu X, "Molecular analysis of a storeoperated and 2-acetyl-sn-glycerol-sensitive non-selective cation channel. Heteromeric assembly of TRPC1-TRPC3", J Biol Chem, 280, pp.21600~21606 (2005)
- Gudermann T, "Activation, subunit composition and physiological relevance of DAG-sensitive TRPC proteins", Novartis Found Symp, 258, pp.103~118 (2004)
- Zagranichnaya TK, "Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells", J Biol Chem, 280, pp.29559~29569 (2005)
- Poteser M, "TRPC3 and TRPC4 associate to form a redox-sensitive cation channel. Evidence for expression of native TRPC3-TRPC4heteromeric channels in endothelial cells", J Biol Chem, 281, pp.13588~13595 (2006)
- Plant TD, "TRPC4 and TRPC5 : receptor-operated Ca2+-permeable nonselective cation channels", Cell Calcium, 33, pp.441~450 (2003)
- Plant TD, "Receptor-operated cation channels formed by TRPC4 and TRPC5", Naunyn Schmiedebergs Arch Pharmacol, 371, pp.266~276 (2005)
- Venkatachalam K, "Lysosomal localization of TRPML3 depends on TRPML2and the mucolipidosis-associated protein TRPML1", J Biol Chem, 281, pp.17517~17527 (2006)
- Curcio-Morelli C, "Functional multimerization of mucolipin channel proteins", J Cell Physiol, 222, pp.328~335 (2010)
- Tsuruda PR, "Coiled coils direct assembly of a cold-activated TRP channel", Neuron, 51, pp.201~212 (2006)
- Chubanov V, "Emerging roles of TRPM6", TRPM7 channel kinase signal transduction complexes, 2005, pp.371, 334~341
- Chubanov V, "Disruption of TRPM6", TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia, 2004, pp.101, 2894~2899
- Jiang LH, "Subunit interaction in channel assembly and functional regulation of transient receptor potential melastatin(TRPM)channels", Biochem Soc Trans, 35, pp.86~88 (2007)
- Li M, "Functional characterization of homo-and heteromeric channel kinases TRPM6 and TRPM7", J Gen Physiol, 127, pp.525~537 (2006)
- Cheng W, "Thermosensitive TRPV channel subunits coassemble into heteromeric channels with intermediate conductance and gating properties", J Gen Physiol, 129, pp.191~207 (2007)
- Hellwig N, "Homo-and heteromeric assembly of TRPV channel subunits", J Cell Sci, 118, pp.917~928 (2005)
- Liapi A, "Extensive co-localization and heteromultimer formation of the vanilloid receptorlike protein TRPV2 and the capsaicin receptor TRPV1 in the adult rat cerebral cortex", Eur J Neurosci, 22, pp.825~834 (2005)
- Smith GD, "TRPV3is a temperature-sensitive vanilloid receptor-like protein", Nature, 418, pp.186~190 (2002)
- Garcia-Sanz N, "Identification of a tetramerization domain in the C terminus of the vanilloid receptor", J Neurosci, 24, pp.5307~5314 (2004)
- Vlachova V, "Functional role of C-terminal cytoplasmic tail of rat vanilloid receptor 1", J Neurosci, 23, pp.1340~1350 (2003)
- Zhang F, "Identification of a tetrameric assembly domain in the C terminus of heat-activated TRPV1 channels", J Biol Chem, 286, pp.15308~15316 (2011)
- Kopanska KS, "Tensile forces originating from cancer spheroids facilitate tumor invasion", PLoS One, 11, pp.e0156442~ (2016)
- Wei SC, "Forcing through Tumor Metastasis : The Interplay between tissue rigidity and epithelial-mesenchymal transition", Trends Cell Biol, 26, pp.111~120 (2016)
- Broders-Bondon F, "Mechanotransduction in tumor progression : The dark side of the force", J Cell Biol, 217, pp.1571~1587 (2018)
- Chubanov V, "Role of kinase-coupled TRP channels in mineral homeostasis", Pharmacol Ther, 184, pp.159~176 (2018)
- Schilling T, "TRPM7regulates proliferation and polarisation of macrophages", J Cell Sci, 127, pp.4561~4566 (2014)
- Clark K, "TRPM7, a novel regulator of actomyosin contractility and cell adhesion", EMBO J, 25, pp.290~301 (2006)
- Nishitani WS, "Rapid and localized mechanical stimulation and adhesion assay : TRPM7 involvement in calcium signaling and cell adhesion", PLoS One, 10, pp.e0126440~ (2015)
- Gao SL, "TRPM7 is overexpressed in bladder cancer and promotes proliferation, migration, invasion and tumor growth", Oncol Rep, 38, pp.1967~1976 (2017)
- Middelbeek J, "TRPM7 is required for breast tumor cell metastasis", Cancer Res, 72, pp.4250~4261 (2012)
- Wei C, "Calcium flickers steer cell migration", Nature, 457, pp.901~905 (2009)
- Su LT, "TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain", J Biol Chem, 281, pp.11260~11270 (2006)
- Guilbert A, "Transient receptor potential melastatin 7 is involved in oestrogen receptor-negative metastatic breast cancer cells migration through its kinase domain", Eur J Cancer, 49, pp.3694~3707 (2013)
- Meng X, "TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway", Cancer Lett, 333, pp.96~102 (2013)
- Clark K, "TRPM7regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation", J Mol Biol, 378, pp.790~803 (2008)
- Chen JP, "TRPM7 promotes the metastatic process in human nasopharyngeal carcinoma", Cancer Lett, 356, pp.483~490 (2015)
- Chen JP, "TRPM7 regulates the migration of human nasopharyngeal carcinoma cell by mediating Ca(2+)influx", Cell Calcium, 47, pp.425~432 (2010)
- Yee NS, "Aberrant over-expression of TRPM7 ion channels in pancreatic cancer : required for cancer cell invasion and implicated in tumor growth and metastasis", Biol Open, 4, pp.507~514 (2015)
- Rybarczyk P, "The transient receptor potential melastatin 7 channel regulates pancreatic cancer cell invasion through the Hsp90alpha", uPA, Neoplasia, pp.2017, 19[DOI]
- Yee NS, "TRPM7and TRPM8 ion channels in pancreatic adenocarcinoma:potential roles as cancer biomarkers and targets", Scientifica (Cairo), 2012, pp.415158~ (2012)
- Wang J, "TRPM7 is required for ovarian cancer cell growth, migration and invasion", Biochem Biophys Res Commun, 454, pp.547~553 (2014)
- Dhennin-Duthille I, "High expression of transient receptor potential channels in human breast cancer epithelial cells and tissues : correlation with pathological parameters", Cell Physiol Biochem, 28, pp.813~822 (2011)
- Jiang J, "Transient receptor potential melastatin 7-like current in human head and neck carcinoma cells : role in cell proliferation", Cancer Res, 67, pp.10929~10938 (2007)
- Yee NS, "Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer", Dis Model Mech, 4, pp.240~254 (2011)
- Caceres M, "TRPM4 Is a novel component of the adhesome required for focal adhesion disassembly, migration and contractility", PLoS One, 10, pp.e0130540~ (2015)
- Almasi S, "TRPM2ion channel promotes gastric cancer migration, invasion and tumor growth through the AKT signaling pathway", Sci Rep, 9, pp.4182~ (2019)
- Lee WH, "TRPV4regulates breast cancer cell extravasation, stiffness and actin cortex", Sci Rep, 6, pp.27903~ (2016)
- Lee WH, "TRPV4 plays a role in breast cancer cell migration via Ca(2+)-dependent activation of AKT and downregulation of E-cadherin cell cortex protein", Oncogenesis, 6, pp.e338~ (2017)
- Xie R, "Calcium promotes human gastric cancer via a novel coupling of calcium-sensing receptor and TRPV4 channel", Cancer Res, 77, pp.6499~6512 (2017)
- Waning J, "A novel function of capsaicin-sensitive TRPV1 channels : involvement in cell migration", Cell Calcium, 42, pp.17~25 (2007)
- Sahai E, "Illuminating the metastatic process", Nat Rev Cancer, 7, pp.737~749 (2007)
- Jemal A, "Global cancer statistics", CA Cancer J Clin, 61, pp.69~90 (2011)
- Siegel RL, "Cancer statistics, 2018", CA Cancer J Clin, 68, pp.7~30 (2018)
- Gkika D, "TRP channels in prostate cancer: the good, the bad and the ugly?", Asian J Androl, 13, pp.673~676 (2011)
- Prevarskaya N, "Differential role of TRP channels in prostate cancer", Biochem Soc Trans, 35, pp.133~135 (2007)
- Van Haute C, "TRP channels in human prostate", Scientific World Journal, 10, pp.1597~1611 (2010)
- Flourakis M, "Insights into Ca2+ homeostasis of advanced prostate cancer cells", Biochim Biophys Acta, 1793, pp.1105~1109 (2009)
- Prevarskaya N, "Calcium in tumour metastasis : new roles for known actors", Nat Rev Cancer, 11, pp.609~618 (2011)
- Skryma R, "From urgency to frequency : facts and controversies of TRPs in the lower urinary tract", Nat Rev Urol, 8, pp.617~630 (2011)
- Gkika D, "TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity", J Cell Biol, 208, pp.89~107 (2015)
- Holzmann C, "Transient receptor potential melastatin 4 channel contributes to migration of androgen-insensitive prostate cancer cells", Oncotarget, 6, pp.41783~41793 (2015)
- Hong X, "MicroRNA-150 suppresses epithelial-mesenchymal transition, invasion, and metastasis in prostate cancer through the TRPM4-mediated betacatenin signaling pathway", Am J Physiol Cell Physiol, 316, pp.C463~C480 (2019)
- Sagredo AI, "TRPM4channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines", J Cell Physiol, 234, pp.2037~2050 (2019)
- Hantute-Ghesquier A, "TRPM family channels in cancer", Pharmaceuticals (Basel), 11, pp.58~ (2018)
- Schinke EN, "A novel approach to identify driver genes involved in androgenindependent prostate cancer", Mol Cancer, 13, pp.120~ (2014)
- Chen L, "Downregulation of TRPM7 suppressed migration and invasion by regulating epithelial-mesenchymal transition in prostate cancer cells", Med Oncol, 34, pp.127~ (2017)
- Czifra G, "Increased expressions of cannabinoid receptor-1 and transient receptor potential vanilloid-1 in human prostate carcinoma", J Cancer Res Clin Oncol, 135, pp.507~514 (2009)
- Sanchez AM, "Induction of apoptosis in prostate tumor PC-3 cells and inhibition of xenograft prostate tumor growth by the vanilloid capsaicin", Apoptosis, 11, pp.89~99 (2006)
- Malagarie-Cazenave S, "Capsaicin, a component of red peppers, induces expression of androgen receptor via PI3K and MAPK pathways in prostate LNCaP cells", FEBS Lett, 583, pp.141~147 (2009)
- Monet M, "Role of cationic channel TRPV2 in promoting prostate cancer migration and progression to androgen resistance", Cancer Res, 70, pp.1225~1235 (2010)
