본문 바로가기
KERD
논문KCI 등재

Remodeling of host glycoproteins during bacterial infection

Yeolhoe Kim|Jeong Yeon Ko|Won Ho Yang
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2021.11|BMB Reports|제54권 제11호|pp. 541-544

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

pathogenesisremodelingbacterial infectionprotein glycosylation
주제분류화학

초록

Protein glycosylation is a common post-translational modificationfound in all living organisms. This modification in bacterialpathogens plays a pivotal role in their infectious processes includingpathogenicity, immune evasion, and host-pathogen interactions. Importantly, many key proteins of host immune systemsare also glycosylated and bacterial pathogens can notably modulateglycosylation of these host proteins to facilitate pathogenesisthrough the induction of abnormal host protein activityand abundance. In recent years, interest in studying the regulationof host protein glycosylation caused by bacterial pathogensis increasing to fully understand bacterial pathogenesis. In this review, we focus on how bacterial pathogens regulateremodeling of host glycoproteins during infections to promotethe pathogenesis.

Abstract

Protein glycosylation is a common post-translational modificationfound in all living organisms. This modification in bacterialpathogens plays a pivotal role in their infectious processes includingpathogenicity, immune evasion, and host-pathogen interactions. Importantly, many key proteins of host immune systemsare also glycosylated and bacterial pathogens can notably modulateglycosylation of these host proteins to facilitate pathogenesisthrough the induction of abnormal host protein activityand abundance. In recent years, interest in studying the regulationof host protein glycosylation caused by bacterial pathogensis increasing to fully understand bacterial pathogenesis. In this review, we focus on how bacterial pathogens regulateremodeling of host glycoproteins during infections to promotethe pathogenesis.

참고문헌 (38)

  1. Bhat AH, "Protein glycosylation : sweet or bitter for bacterial pathogens?", Crit Rev Microbiol, 45, pp.82~102 (2019)
  2. Moremen KW, "Vertebrate protein glycosylation : diversity, synthesis and function", Nat Rev Mol Cell Biol, 13, pp.448~462 (2012)
  3. Pinho SS, "Glycosylation in cancer : mechanisms and clinical implications", Nat Rev Cancer, 15, pp.540~555 (2015)
  4. Rudd P, "Glycosylation and the immune system", Science, 291, pp.2370~2376 (2001)
  5. Sjögren J, "Bacterial glycosidases in pathogenesis and glycoengineering", Future Microbiol, 9, pp.1039~1051 (2014)
  6. Nothaft H, "Protein glycosylation in bacteria : sweeter than ever", Nat Rev Microbiol, 8, pp.765~778 (2010)
  7. Szymanski CM, "Protein glycosylation in bacterial mucosal pathogens", Nat Rev Microbiol, 3, pp.225~237 (2005)
  8. Poole J, "Glycointeractions in bacterial pathogenesis", Nat Rev Microbiol, 16, pp.440~452 (2018)
  9. Jank T, "Bacterial glycosyltransferase toxins", Cell Microbiol, 17, pp.1752~1765 (2015)
  10. Lu Q, "Sweet talk : protein glycosylation in bacterial interaction with the host", Trends Microbiol, 23, pp.630~641 (2015)
  11. Sudhakara P, "Bacterial sialoglycosidases in virulence and pathogenesis", Pathogens, 8, pp.39~ (2019)
  12. Grewal PK, "The Ashwell receptor mitigates the lethal coagulopathy of sepsis", Nat Med, 14, pp.648~655 (2008)
  13. Chen GY, "Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction", Nat Biotechnol, 29, pp.428~435 (2011)
  14. Paulson JC, "Sialidase inhibitors DAMPen sepsis", Nat Biotechnol, 29, pp.406~407 (2011)
  15. Kurniyati K, "A surfaceexposed neuraminidase affects complement resistance and virulence of the oral spirochaete Treponema denticola", Mol Microbiol, 89, pp.842~856 (2013)
  16. Collin M, "EndoS, a novel secreted protein from Streptococcus pyogenes with endoglycosidase activity on human IgG", EMBO J, 20, pp.3046~3055 (2001)
  17. Naegeli A, "Streptococcus pyogenes evades adaptive immunity through specific IgG glycan hydrolysis", J Exp Med, 216, pp.1615~1629 (2019)
  18. Collin M, "A novel secreted endoglycosidase from Enterococcus faecalis with activity on human immunoglobulin G and ribonuclease B", J Biol Chem, 279, pp.22558~22570 (2004)
  19. Garbe J, "EndoE from Enterococcus faecalis hydrolyzes the glycans of the biofilm inhibiting protein lactoferrin and mediates growth", PLoS One, 9, pp.e91035~ (2014)
  20. Renzi F, "The N-glycan glycoprotein deglycosylation complex(Gpd)from Capnocytophaga canimorsus deglycosylates human IgG", PLoS Pathog, 7, pp.17~ (2011)
  21. Ding J, "Structural and functional insights into host death domains inactivation by the bacterial arginine GlcNAcyltransferase effector", Mol Cell, 74, pp.922~935 (2019)
  22. Gao X, "NleB, a bacterial effector with glycosyltransferase activity, targets GAPDH function to inhibit NF-κB activation", Cell Host Microbe, 13, pp.87~99 (2013)
  23. Scott NE, "The bacterial arginine glycosyltransferase effector NleB preferentially modifies Fas-associated death domain protein(FADD)", J Biol Chem, 292, pp.17337~17350 (2017)
  24. Jank T, "A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins", Nat Struct Mol Biol, 20, pp.1273~1280 (2013)
  25. Belyi Y, "Legionella pneumophila glucosyltransferase inhibits host elongation factor 1A", Proc Natl Acad Sci U S A, 103, pp.16953~16958 (2006)
  26. Tzivelekidis T, "AminoacyltRNA-charged eukaryotic elongation factor 1A is the bona fide substrate for Legionella pneumophila effector glucosyltransferases", PLoS One, 6, pp.e29525~ (2011)
  27. Kuehne SA, "The role of toxin A and toxin B in Clostridium difficile infection", Nature, 467, pp.711~713 (2010)
  28. Aktories K, "Clostridium difficile toxin biology", Annu Rev Microbiol, 71, pp.281~307 (2017)
  29. Yang M, "CagA, a major virulence factor of Helicobacter pylori, promotes the production and underglycosylation of IgA1in DAKIKI cells", Biochem Biophys Res Commun, 444, pp.276~281 (2014)
  30. Zhu TT, "Helicobacter pylori participates in the pathogenesis of IgA nephropathy", Ren Fail, 38, pp.1398~1404 (2016)
  31. Vaishnava S, "Alkaline phosphatase : keeping the peace at the gut epithelial surface", Cell Host Microbe, 2, pp.365~367 (2007)
  32. Yang WH, "Recurrent infection progressively disables host protection against intestinal inflammation", Science, 358, pp.eaao5610~ (2017)
  33. Yang WH, "Accelerated aging and clearance of host anti-inflammatory enzymes by discrete pathogens fuels sepsis", Cell Host Microbe, 24, pp.500~513 (2018)
  34. Barel M, "Host glycosylation pathways and the unfolded protein response contribute to the infection by Francisella", Cell Microbiol, 18, pp.1763~1781 (2016)
  35. Goto Y, "Innate lymphoid cells regulate intestinal epithelial cell glycosylation", Science, 345, pp.1254009~ (2014)
  36. Goto Y, "Epithelial glycosylation in gut homeostasis and inflammation", Nat Immunol, 17, pp.1244~1251 (2016)
  37. Pham TA, "Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen", Cell Host Microbe, 16, pp.504~516 (2014)
  38. Pickard JM, "Rapid fucosylation of intestinal epithelium sustains hostcommensal symbiosis in sickness", Nature, 514, pp.638~641 (2014)

관련 논문AI추천

Host-Pathogen Interactions in Urinary Tract Infections고영휘, 송필현, 최재영대한요로생식기감염학회 · Urogenital Tract Infection2019 · 제14권 제3호Structural insights showing how arginine is able to be glycosylated by pathogenic effector proteins박준배, 유영기, 조현수생화학분자생물학회 · BMB Reports2018 · 제51권 제12호Host-Pathogen Interactions Operative during Mycobacteroides abscessus Infection조은경, Park Eun-Jin, Silwal Prashanta대한면역학회 · Immune Network2021 · 제21권 제6호Host-Directed Therapeutics as a Novel Approach for Tuberculosis Treatment김예람, 양철수한국미생물·생명공학회 · Journal of Microbiology and Biotechnology2017 · 제27권 제9호Glycoscience aids in biomarker discovery안현주, Serenus Hua생화학분자생물학회 · BMB Reports2012 · 제45권 제6호Regulation of Adaptive Immunity by Lipid Post-translational ModificationsAimee Wu, Autumn G. York, Jonathan R. Mattingly대한면역학회 · Immune Network2025 · 제25권 제1호

이 간행물의 다른 논문 (6건)

Anisomycin protects against sepsis by attenuating IκB kinase-dependent NF-κB activation and inflammatory gene expression박경림, 박영준, 이선진, Su Wol Chung, Minkyung Park, Jeong-Ki Minpp. 545-550Investigation of the effect of Staufen1 overexpression on the HIV-1 virus productionGa-Na Kim, Kyung-Lee Yu, Hae-In Kim, Seong-won Park, Jun-Hyun Bae, Ji Chang Youpp. 551-556Anti-inflammatory effects of N-cyclooctyl-5-methylthiazol-2-amine hydrobromide on lipopolysaccharide-induced inflammatory response through attenuation of NLRP3 activation in microglial cellsJee-Yin Ahn, Soo Young Choi, Sung-Woo Cho, Ji-Eun Kim, Seung-Ju Yang, Eun-A Kim, Kyouk Hwangpp. 557-562Drug evaluation based on phosphomimetic PDHA1 reveals the complexity of activity-related cell death in A549 non-small cell lung cancer cellsLing Jin, Jung Ho Han, In-Kyu Lee, 박성미, 김재호, 하기태, Sung-Jin Bae, Dongryeol Ryu, Bo-Sung Kim, 조민경pp. 563-568Neuromedin B modulates phosphate-induced vascular calcification김형준, 배수경, Hyun-Joo Park, Yeon Kim, 배문경, Mi-Kyoung Kimpp. 569-574
원문 보기