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From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes

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Cellular senescence is a process by which cells enter a state of permanent cell cycle arrest. It is commonly believed to underlie organismal aging and age-associated diseases. However, the mechanism by which cellular senescence contributes to aging and age-associated pathologies remains unclear. Recent studies showed that senescent cells exert detrimental effects on the tissue microenvironment, generating pathological facilitators or aggravators. The most significant environmental effector resulting from senescent cells is the senescence-associated secretory phenotype (SASP), which is constituted by a strikingly increased expression and secretion of diverse pro-inflammatory cytokines. Careful investigation into the components of SASPs and their mechanism of action, may improve our understanding of the pathological backgrounds of age-associated diseases. In this review, we focus on the differential expression of SASP-related genes, in addition to SASP components, during the progress of senescence. We also provide a perspective on the possible action mechanisms of SASP components, and potential contributions of SASP-expressing senescent cells, to age-associated pathologies.

Abstract

Cellular senescence is a process by which cells enter a state of permanent cell cycle arrest. It is commonly believed to underlie organismal aging and age-associated diseases. However, the mechanism by which cellular senescence contributes to aging and age-associated pathologies remains unclear. Recent studies showed that senescent cells exert detrimental effects on the tissue microenvironment, generating pathological facilitators or aggravators. The most significant environmental effector resulting from senescent cells is the senescence-associated secretory phenotype (SASP), which is constituted by a strikingly increased expression and secretion of diverse pro-inflammatory cytokines. Careful investigation into the components of SASPs and their mechanism of action, may improve our understanding of the pathological backgrounds of age-associated diseases. In this review, we focus on the differential expression of SASP-related genes, in addition to SASP components, during the progress of senescence. We also provide a perspective on the possible action mechanisms of SASP components, and potential contributions of SASP-expressing senescent cells, to age-associated pathologies.

참고문헌 (99)

  1. Chen D, "Insulin-like growth factor-binding protein-7 functions as a potential tumor suppressor in hepatocellular carcinoma", Clin Cancer Res, 17, pp.6693~6701 (2011)
  2. Jones AW, "PGC-1 family coactivators and cell fate: roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria-nucleus signalling", Mitochondrion, 12, pp.86~99 (2012)
  3. Chatrchyan S, "Measurement of the inclusive jet cross section in pp collisions at radicals = 7 TeV", Phys Rev Lett, 107, pp.132001~ (2011)
  4. Sunderic M, "Protein molecular forms of insulin-like growth factor binding protein-2 change with aging", Exp Gerontol, 58, pp.154~158 (2014)
  5. Minamino T, "Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction", Circulation, 105, pp.1541~1544 (2002)
  6. Youdim MB, "The role of iron in senescence of dopaminergic neurons in Parkinson's disease", J Neural Transm Suppl, 40, pp.57~67 (1993)
  7. Hengstler JG, "Oxidative stress: from modification of cell-cycle related events, secondary messenger function, dysregulation of small GTPases, protein kinases and phosphatases to redox-sensitive cancer models", Arch Toxicol, 82, pp.271~272 (2008)
  8. Jones RM, "Interpretation and prediction of inhaled drug particle accumulation in the lung and its associated toxicity", Xenobiotica, 42, pp.86~93 (2012)
  9. Hung WY, "Mitochondrial dysfunction promotes cell migration via reactive oxygen species-enhanced beta5-integrin expression in human gastric cancer SC-M1 cells", Biochim Biophys Acta, 1820, pp.1102~1110 (2012)
  10. Hoffmeister A, "The HMG-I", Y-related protein p8 binds to p300 and Pax2 transactivation domain-interacting protein to regulate the transactivation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter, 2002, pp.277, 22314~22319
  11. Rohman L, "Chilaiditi's sign", Emerg Med J, 29, pp.86~ (2012)
  12. Engelberg B, "Exploring minimally invasive options: managing demands, expectations, and outcomes", Dent Today, 31, pp.86~88 (2012)
  13. West MD, "Altered expression of plasminogen activator and plasminogen activator inhibitor during cellular senescence", Exp Gerontol, 31, pp.175~193 (1996)
  14. Lapierre LR, "Lessons from C. elegans:signaling pathways for longevity", Trends Endocrinol Metab, 23, pp.637~644 (2012)
  15. Comi P, "Senescencedependent regulation of type 1 plasminogen activator inhibitor in human vascular endothelial cells", Exp Cell Res, 219, pp.304~308 (1995)
  16. Sabharwal SS, "Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?", Nat Rev Cancer, 14, pp.709~721 (2014)
  17. Ballinger SW, "Beyond retrograde and anterograde signalling: mitochondrial-nuclear interactions as a means for evolutionary adaptation and contemporary disease susceptibility", Biochem Soc Trans, 41, pp.111~117 (2013)
  18. Dimri GP, "A biomarker that identifies senescent human cells in culture and in aging skin in vivo", Proc Natl Acad Sci U S A, 92, pp.9363~9367 (1995)
  19. Bateman A, "The granulin gene family:from cancer to dementia", Bioessays, 31, pp.1245~1254 (2009)
  20. Beckman KB, "Endogenous oxidative damage of mtDNA", Mutat Res, 424, pp.51~58 (1999)
  21. Biswas G, "Retrograde Ca2+ signaling in C2C12 skeletal myocytes in response to mitochondrial genetic and metabolic stress: a novel mode of inter-organelle crosstalk", EMBO J, 18, pp.522~533 (1999)
  22. Biswas G, "Mitochondria to nucleus stress signaling: a distinctive mechanism of NFkappaB", Rel activation through calcineurin-mediated inactivation of IkappaBbeta, 2003, pp.161, 507~519
  23. Berneburg M, "'To repair or not to repair - no longer a question':repair of mitochondrial DNA shielding against age and cancer", Exp Dermatol, 15, pp.1005~1015 (2006)
  24. He X, "Suppression of mitochondrial complex I influences cell metastatic properties", PLoS One, 8, pp.e61677~ (2013)
  25. Boiteux S, "The human OGG1gene: structure, functions, and its implication in the process of carcinogenesis", Arch Biochem Biophys, 377, pp.1~8 (2000)
  26. Brandon M, "Mitochondrial mutations in cancer", Oncogene, 25, pp.4647~4662 (2006)
  27. Zhang YQ, "Expression and modification of ARC(apoptosis repressor with a CARD domain)is distinctly regulated by oxidative stress in cancer cells", J Cell Biochem, 104, pp.818~825 (2008)
  28. Bogenhagen DF, "Enzymology of mitochondrial base excision repair", Prog Nucleic Acid Res Mol Biol, 68, pp.257~271 (2001)
  29. Guettouche T, "Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress", BMC Biochem, 6, pp.4~ (2005)
  30. Butow RA, "Mitochondrial signaling:the retrograde response", Mol Cell, 14, pp.1~15 (2004)
  31. Byun HO, "GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor(TGF)beta1-induced senescence", Exp Cell Res, 318, pp.1808~1819 (2012)
  32. Amuthan G, "Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells", Oncogene, 21, pp.7839~7849 (2002)
  33. Byun HO, "Mitochondrial dysfunction by complex II inhibition delays overall cell cycle progression via reactive oxygen species production", J Cell Biochem, 104, pp.1747~1759 (2008)
  34. Campagnoni CW, "Identification of genes in the oligodendrocyte lineage through the analysis of conditionally immortalized cell lines", Dev Neurosci, 23, pp.452~463 (2001)
  35. Cano CE, "Nupr1 : the Swiss-knife of cancer", J Cell Physiol, 226, pp.1439~1443 (2011)
  36. Carew JS, "Mitochondrial defects in cancer", Mol Cancer, 1, pp.9~ (2002)
  37. Chae S, "A systems approach for decoding mitochondrial retrograde signaling pathways", Sci Signal, 6, pp.4~ (2013)
  38. Chang CJ, "Mitochondrial dysfunction-induced amphiregulin upregulation mediates chemo-resistance and cell migration in HepG2 cells", Cell Mol Life Sci, 66, pp.1755~1765 (2009)
  39. Chatterjee A, "Mitochondrial DNA mutations in human cancer", Oncogene, 25, pp.4663~4674 (2006)
  40. Stein GH, "Molecular mechanisms for the senescent cell cycle arrest", J Investig Dermatol Symp Proc, 3, pp.14~18 (1998)
  41. Hwang ES, "A comparative analysis of the cell biology of senescence and aging", Cell Mol Life Sci, 66, pp.2503~2524 (2009)
  42. Cheung ST, "Granulin-epithelin precursor overexpression promotes growth and invasion of hepatocellular carcinoma", Clin Cancer Res, 10, pp.7629~7636 (2004)
  43. Chowdhury UR, "Emerging role of nuclear protein 1(NUPR1)in cancer biology", Cancer Metastasis Rev, 28, pp.225~232 (2009)
  44. Clayton DA, "Nuclear-mitochondrial intergenomic communication", Biofactors, 7, pp.203~205 (1998)
  45. Cortopassi G, "Modelling the effects of age-related mtDNA mutation accumulation; complex I deficiency, superoxide and cell death", Biochim Biophys Acta, 1271, pp.171~176 (1995)
  46. Kim YM, "Sterol regulatory element-binding protein(SREBP)-1-mediated lipogenesis is involved in cell senescence", J Biol Chem, 285, pp.29069~29077 (2010)
  47. = 7 TeV, "Phys Rev Lett", 2011, 112001~
  48. Czarnecka AM, "Mitochondrial DNA mutations in cancer--from bench to bedside", Front Biosci, 15, pp.437~460 (2010)
  49. Seo M, "PFKFB3 regulates oxidative stress homeostasis via its S-glutathionylation in cancer", J Mol Biol, 426, pp.830~842 (2014)
  50. Millis AJ, "Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts", Exp Cell Res, 201, pp.373~379 (1992)
  51. Coppe JP, "Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor", PLoS Biol, 6, pp.2853~2868 (2008)
  52. Imamura H, "Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy", J Hepatol, 38, pp.200~207 (2003)
  53. Rodier F, "Four faces of cellular senescence", J Cell Biol, 192, pp.547~556 (2011)
  54. Vital P, "The senescence-associated secretory phenotype promotes benign prostatic hyperplasia", Am J Pathol, 184, pp.721~731 (2014)
  55. Han X, "Interleukin-10 protects against atherosclerosis by modulating multiple atherogenic macrophage function", Thromb Haemost, 113, pp.505~512 (2015)
  56. Groppo R, "CPEB control of NF-kappaB nuclear localization and interleukin-6 production mediates cellular senescence", Mol Cell Biol, 31, pp.2707~2714 (2011)
  57. Kulju KS, "Increased p53 protein associated with aging in human diploid fibroblasts", Exp Cell Res, 217, pp.336~345 (1995)
  58. Salminen A, "Glycolysis links p53function with NF-kappaB signaling: impact on cancer and aging process", J Cell Physiol, 224, pp.1~6 (2010)
  59. Brookes S, "Contribution of p16(INK4a)to replicative senescence of human fibroblasts", Exp Cell Res, 298, pp.549~559 (2004)
  60. Delsite R, "Nuclear genes involved in mitochondria-to-nucleus communication in breast cancer cells", Mol Cancer, 1, pp.6~ (2002)
  61. Demorrow S, "Progranulin : a novel regulator of gastrointestinal cancer progression", Transl Gastrointest Cancer, 2, pp.145~151 (2013)
  62. Di Bella D, "Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28", Nat Genet, 42, pp.313~321 (2010)
  63. Dzierzbicki P, "Repair of oxidative damage in mitochondrial DNA of Saccharomyces cerevisiae: involvement of the MSH1-dependent pathway", DNA Repair (Amst), 3, pp.403~411 (2004)
  64. DiMauro S, "Mitochondrial respiratory-chain diseases", N Engl J Med, 348, pp.2656~2668 (2003)
  65. Encinar JA, "Human p8is a HMG-I", Y-like protein with DNA binding activity enhanced by phosphorylation, 2001, pp.276, 2742~2751
  66. Finley LW, "The coordination of nuclear and mitochondrial communication during aging and calorie restriction", Ageing Res Rev, 8, pp.173~188 (2009)
  67. Ashok BT, "Immunochemical detection of oxidative DNA damage in cancer and aging using anti-reactive oxygen species modified DNA monoclonal antibody", Int J Biochem Cell Biol, 30, pp.1367~1377 (1998)
  68. Gardiner K, "Human genome organization", Curr Opin Genet Dev, 5, pp.315~322 (1995)
  69. Goruppi S, "Signaling pathways and late-onset gene induction associated with renal mesangial cell hypertrophy", EMBO J, 21, pp.5427~5436 (2002)
  70. Giroux V, "p8 is a new target of gemcitabine in pancreatic cancer cells", Clin Cancer Res, 12, pp.235~241 (2006)
  71. Goruppi S, "The pro-hypertrophic basic helix-loop-helix protein p8 is degraded by the ubiquitin", proteasome system in a protein kinase B, J Biol Chem, pp.2004, 279[DOI]
  72. Gredilla R, "Nuclear and mitochondrial DNA repair in selected eukaryotic aging model systems", Oxid Med Cell Longev, 2012, pp.282438~ (2012)
  73. Grollman AP, "Mutagenesis by 8-oxoguanine:an enemy within", Trends Genet, 9, pp.246~249 (1993)
  74. Guha M, "Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics", Mitochondrion, 13, pp.577~591 (2013)
  75. Takahashi T, "Balloon-occluded retrograde transvenous obliteration for gastric varices in a child with extrahepatic portal venous obstruction", J Nippon Med Sch, 76, pp.173~178 (2009)
  76. Hamidi T, "Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis", J Clin Invest, 122, pp.2092~2103 (2012)
  77. Hamidi T, "Nupr1-aurora kinase A pathway provides protection against metabolic stress-mediated autophagic-associated cell death", Clin Cancer Res, 18, pp.5234~5246 (2012)
  78. Haque A, "Lack of mitochondrial DNA enhances growth of hepatocellular carcinoma in vitro and in vivo", Hepatol Res, 36, pp.209~216 (2006)
  79. Hashiguchi K, "The C-terminal alphaO helix of human Ogg1 is essential for 8-oxoguanine DNA glycosylase activity: the mitochondrial beta-Ogg1 lacks this domain and does not have glycosylase activity", Nucleic Acids Res, 32, pp.5596~5608 (2004)
  80. Brew K, "Tissue inhibitors of metalloproteinases: evolution, structure and function", Biochim Biophys Acta, 1477, pp.267~283 (2000)
  81. Reichenstein M, "ACTH induces TIMP-1 expression and inhibits collagenase in adrenal cortex cells", Mol Cell Endocrinol, 215, pp.109~114 (2004)
  82. Binder BR, "Plasminogen activator inhibitor 1: physiological and pathophysiological roles", News Physiol Sci, 17, pp.56~61 (2002)
  83. Alessi MC, "Plasminogen activator inhibitor-1, adipose tissue and insulin resistance", Curr Opin Lipidol, 18, pp.240~245 (2007)
  84. Gils A, "The structural basis for the pathophysiological relevance of PAI-I in cardiovascular diseases and the development of potential PAI-I inhibitors", Thromb Haemost, 91, pp.425~437 (2004)
  85. Schroder WA, "The role of SerpinB2 in immunity", Crit Rev Immunol, 31, pp.15~30 (2011)
  86. Hwa V, "The insulin-like growth factor-binding protein(IGFBP)superfamily", Endocr Rev, 20, pp.761~787 (1999)
  87. Stewart CE, "Potentiation of insulin-like growth factor-I (IGF-I)activity by an antibody: supportive evidence for enhancement of IGF-I bioavailability in vivo by IGF binding proteins", Endocrinology, 133, pp.1462~1465 (1993)
  88. Clemmons DR, "Role of insulin-like growth factor binding proteins in the control of IGF actions", Prog Growth Factor Res, 6, pp.357~366 (1995)
  89. Orjalo AV, "Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6", IL-8 cytokine network, 2009, pp.106, 17031~17036
  90. Kim YM, "Implications of time-series gene expression profiles of replicative senescence", Aging Cell, 12, pp.622~634 (2013)
  91. Chow FL, "Many membrane proteins undergo ectodomain shedding by proteolytic cleavage. Does one sheddase do the job on all of these proteins?", IUBMB Life, 59, pp.44~47 (2007)
  92. Hayashida K, "Molecular and cellular mechanisms of ectodomain shedding", Anat Rec (Hoboken), 293, pp.925~937 (2010)
  93. Athauda G, "c-Met ectodomain shedding rate correlates with malignant potential", Clin Cancer Res, 12, pp.4154~4162 (2006)
  94. Acosta JC, "A role for CXCR2 in senescence, but what about in cancer?", Cancer Res, 69, pp.2167~2170 (2009)
  95. Freund A, "Inflammatory networks during cellular senescence: causes and consequences", Trends Mol Med, 16, pp.238~246 (2010)
  96. Guo H, "Chemokine receptor CXCR2 is transactivated by p53 and induces p38-mediated cellular senescence in response to DNA damage", Aging Cell, 12, pp.1110~1121 (2013)
  97. Kenyon C, "A C. elegans mutant that lives twice as long as wild type", Nature, 366, pp.461~464 (1993)
  98. Elzi DJ, "Plasminogen activator inhibitor 1--insulin-like growth factor binding protein 3 cascade regulates stressinduced senescence", Proc Natl Acad Sci U S A, 109, pp.12052~12057 (2012)
  99. Micutkova L, "Insulin-like growth factor binding protein-6 delays replicative senescence of human fibroblasts", Mech Ageing Dev, 132, pp.468~479 (2011)

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