AcrAB−TolC, a major efflux pump in Gram negative bacteria: toward understanding its operation mechanism
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Antibiotic resistance (AR) is a silent pandemic that kills millionsworldwide. Although the development of new therapeutic agentsagainst antibiotic resistance is in urgent demand, this has presenteda great challenge, especially for Gram-negative bacteriathat have inherent drug-resistance mediated by impermeableouter membranes and multidrug efflux pumps that actively extrudevarious drugs from the bacteria. For the last two decades,multidrug efflux pumps, including AcrAB−TolC, the most clinicallyimportant efflux pump in Gram-negative bacteria, havedrawn great attention as strategic targets for re-sensitizing bacteriato the existing antibiotics. This article aims to provide aconcise overview of the AcrAB−TolC operational mechanism,reviewing its architecture and substrate specificity, as well asthe recent development of AcrAB−TolC inhibitors.
Abstract
Antibiotic resistance (AR) is a silent pandemic that kills millionsworldwide. Although the development of new therapeutic agentsagainst antibiotic resistance is in urgent demand, this has presenteda great challenge, especially for Gram-negative bacteriathat have inherent drug-resistance mediated by impermeableouter membranes and multidrug efflux pumps that actively extrudevarious drugs from the bacteria. For the last two decades,multidrug efflux pumps, including AcrAB−TolC, the most clinicallyimportant efflux pump in Gram-negative bacteria, havedrawn great attention as strategic targets for re-sensitizing bacteriato the existing antibiotics. This article aims to provide aconcise overview of the AcrAB−TolC operational mechanism,reviewing its architecture and substrate specificity, as well asthe recent development of AcrAB−TolC inhibitors.
참고문헌 (97)
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