Discovering the anti-cancer phytochemical rutin against breast cancer through the methodical platform based on traditional medicinal knowledge
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A number of therapeutic drugs have been developed from functionalchemicals found in plants. Knowledge of plants used formedicinal purposes has historically been transmitted by wordof mouth or through literature. The aim of the present study isto provide a systemic platform for the development of leadcompounds against breast cancer based on a traditional medicaltext. To verify our systematic approach, integrating processesconsisted of text mining of traditional medical texts, 3-D virtualdocking screening, and in vitro and in vivo experimentalvalidations were demonstrated. Our text analysis system identifiedrutin as a specific phytochemical traditionally used forcancer treatment. 3-D virtual screening predicted that rutincould block EGFR signaling. Thus, we validated significant anticancereffects of rutin against breast cancer cells through blockadeof EGFR signaling pathway in vitro. We also demonstratedin vivo anti-cancer effects of rutin using the breast cancer recurrencein vivo models. In summary, our innovative approachmight be proper for discovering new phytochemical lead compoundsdesigning for blockade of malignant neoplasm includingbreast cancer.
Abstract
A number of therapeutic drugs have been developed from functionalchemicals found in plants. Knowledge of plants used formedicinal purposes has historically been transmitted by wordof mouth or through literature. The aim of the present study isto provide a systemic platform for the development of leadcompounds against breast cancer based on a traditional medicaltext. To verify our systematic approach, integrating processesconsisted of text mining of traditional medical texts, 3-D virtualdocking screening, and in vitro and in vivo experimentalvalidations were demonstrated. Our text analysis system identifiedrutin as a specific phytochemical traditionally used forcancer treatment. 3-D virtual screening predicted that rutincould block EGFR signaling. Thus, we validated significant anticancereffects of rutin against breast cancer cells through blockadeof EGFR signaling pathway in vitro. We also demonstratedin vivo anti-cancer effects of rutin using the breast cancer recurrencein vivo models. In summary, our innovative approachmight be proper for discovering new phytochemical lead compoundsdesigning for blockade of malignant neoplasm includingbreast cancer.
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