항암화학요법을 받는 위암 환자의 말초신경병증, 수면장애 및 삶의 질의 변화: 전향적 종단 연구
Changes in Chemotherapy-induced Peripheral Neuropathy, Sleep Quality, and Quality of Life following Chemotherapy in Stomach Cancer Patients: a Prospective Study
0
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Purpose: The purpose of this study was to identify the changes of chemotherapy induced peripheral neuropathy (CIPN), sleep quality, and quality of life and their interrelationships following chemotherapy. Methods: A sample of 52 patients who had been diagnosed with stomach cancer receiving oxaliplatin containing chemotherapy were included in a prospective longitudinal study. The assessment tools were Chemotherapy-induced Peripheral Neuropathy 20, Pittsburgh Sleep Quality Index, and EORTC Quality of LifeCancer. The data were collected at three time points: pre-chemotherapy, post-chemotherapy, and three months after the completion of chemotherapy, using questionnaires given between June 2017 and March 2019. Data were analyzed using descriptive statistics, repeated measures analysis of variance, and multiple regression analysis. Results: Post-chemotherapy, 19.2% of patients complained of CIPN and 21.2% exhibited CIPN at three-month follow-up. Repeated measures ANOVA showed a significant increase in CIPN after chemotherapy and it remained high at three-month follow-up (F = 39.90, p< .001). Functional quality of life (F = 8.23, p< .001) and symptom quality of life (F = 7.88, p= .001) also showed significant decreases after chemotherapy, and symptom quality of life remained low at three-month follow-up. However, for sleep quality, no significant main effect of time point was shown. CIPN and sleep quality were a factor influencing quality of life with an explanatory power of 48.3% at post-chemotherapy and 65.3% at three-month follow up. Conclusion: These results suggest that chemotherapy is highly associated with CIPN and symptoms affecting quality of life in cancer patients. Nursing intervention is needed to monitor and relieve these symptoms of patients during the cancer care trajectory.
Abstract
Purpose: The purpose of this study was to identify the changes of chemotherapy induced peripheral neuropathy (CIPN), sleep quality, and quality of life and their interrelationships following chemotherapy. Methods: A sample of 52 patients who had been diagnosed with stomach cancer receiving oxaliplatin containing chemotherapy were included in a prospective longitudinal study. The assessment tools were Chemotherapy-induced Peripheral Neuropathy 20, Pittsburgh Sleep Quality Index, and EORTC Quality of LifeCancer. The data were collected at three time points: pre-chemotherapy, post-chemotherapy, and three months after the completion of chemotherapy, using questionnaires given between June 2017 and March 2019. Data were analyzed using descriptive statistics, repeated measures analysis of variance, and multiple regression analysis. Results: Post-chemotherapy, 19.2% of patients complained of CIPN and 21.2% exhibited CIPN at three-month follow-up. Repeated measures ANOVA showed a significant increase in CIPN after chemotherapy and it remained high at three-month follow-up (F = 39.90, p< .001). Functional quality of life (F = 8.23, p< .001) and symptom quality of life (F = 7.88, p= .001) also showed significant decreases after chemotherapy, and symptom quality of life remained low at three-month follow-up. However, for sleep quality, no significant main effect of time point was shown. CIPN and sleep quality were a factor influencing quality of life with an explanatory power of 48.3% at post-chemotherapy and 65.3% at three-month follow up. Conclusion: These results suggest that chemotherapy is highly associated with CIPN and symptoms affecting quality of life in cancer patients. Nursing intervention is needed to monitor and relieve these symptoms of patients during the cancer care trajectory.
참고문헌 (30)
- Sereno M, "Oxaliplatin induced-neuropathy in digestive tumors", Crit Rev Oncol Hematol, 89, pp.166~178 (2014)
- Mols F, "Chemotherapyinduced peripheral neuropathy and its association with quality of life : a systematic review", Support Care Cancer, 22, pp.2261~2269 (2014)
- Tofthagen C, "Oxaliplatininduced peripheral neuropathy’s effects on health-related quality of life of colorectal cancer survivors", Support Care Cancer, 21, pp.3307~3313 (2013)
- Mols F, "Chemotherapy-induced peripheral neuropathy, physical activity and health-related quality of life among colorectal cancer survivors from the PROFILES registry", J Cancer Surviv, 9, pp.512~522 (2015)
- Trivedi MS, "Management of chemotherapyinduced peripheral neuropathy", Am J Hematol Oncol, 11, pp.4~8 (2015)
- Brami C, "Natural products and complementary therapies for chemotherapy-induced peripheral neuropathy : a systematic review", Crit Rev Oncol Hematol, 98, pp.325~334 (2016)
- Derksen TME, "Lifestyle-related factors in the self-management of chemotherapy-induced peripheral neuropathy in colorectal cancer : a systematic review", Evid Based Complement Alternat Med, 2017, pp.7916031~ (2017)
- 김경연, "암 환자의 말초신경병증 관련 일상활동장애와 삶의 질: 심리적 디스트레스의 매개효과", Journal of Korean Academy of Nursing, 45(5), pp.661~670 (2015), 한국간호과학회
- Irwin MR, "Sleep disturbance, sleep duration, and inflammation : a systematic review and meta-analysis of cohort studies and experimental sleep deprivation", Biol Psychiatry, 80, pp.40~52 (2016)
- 김혜미, "항암화학요법을 받는 위암환자의 말초신경병증, 수면 및 삶의 질에 대한 연구", 기본간호학회지, 25(3), pp.176~184 (2018), 기본간호학회[DOI]
- de Gramont A, "Leucovorin and fluorouracil with or without oxaliplatin as firstline treatment in advanced colorectal cancer", J Clin Oncol, 18, pp.2938~2947 (2000)
- 황원희, "CIPNAT을 이용한 항암화학요법을 받는 암환자들의 말초신경병증 평가", 석사, 간호학과 종양전문간호전공, pp.2013
- 김정혜, "신경독성 항암제를 투여받고 있는 암환자의 말초신경병증 증상과 일상생활 방해정도", Asian Oncology Nursing, 13(3), pp.145~151 (2013), 대한종양간호학회
- 오복자, "대장암 ․ 위암 환자의 항암화학요법 시기에 따른 암 증상, 우울 및 삶의 질의 변화: 전향적 종단 연구", 성인간호학회지, 29(3), pp.313~322 (2017), 한국성인간호학회[DOI]
- 김혜영, "Reliability and Validity of the Korean Version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire to Assess Chemotherapy-induced Peripheral Neuropathy", Journal of Korean Academy of Nursing, 44(6), pp.735~742 (2014), 한국간호과학회
- Fayers PM, "The EORTC QLQ-C30 scoring manual", European Organisation for Research and Treatment of Cancer, ~ (2001)
- Buysse DJ, "The Pittsburgh sleep quality index : a new instrument for psychiatric practice and research", Psychiatry Res, 28, pp.193~213 (1989)
- Sohn SI, "The reliability and validity of the Korean version of the Pittsburgh sleep quality index", Sleep Breath, 16, pp.803~812 (2012)
- Yun YH, "Validation of the Korean version of the EORTC QLQ-C30", Qual Life Res, 13, pp.863~868 (2004)
- Chaiy S., "Social science research methodology" (2000), Hakhyunsa
- 김향미, "암환자의 항암화학요법에 따른 말초신경병증 증상정도와 완화요법", 석사, 간호학과, pp.2012
- 김정혜, "항암화학요법으로 인한 말초신경병증을 경험하는 대장암 환자의 삶의 질", Asian Oncology Nursing, 11(3), pp.254~262 (2011), 대한종양간호학회
- Kolb NA, "The association of chemotherapy-induced peripheral neuropathy symptoms and the risk of falling", JAMA Neurol, 73, pp.860~866 (2016)
- 오복자, "암환자가 경험하는 항암화학요법 관련 말초신경병증", Asian Oncology Nursing, 19(2), pp.81~89 (2019), 대한종양간호학회[DOI]
- Argyriou AA, "Chemotherapy-induced peripheral neurotoxicity(CIPN) : an update", Crit Rev Oncol Hematol, 82, pp.51~77 (2012)
- Visovsky C, "Putting evidence into practice : evidence-based interventions for chemotherapyinduced peripheral neuropathy", Clin J Oncol Nurs, 11, pp.901~913 (2007)
- 석성희, "방사선치료를 받는 여성 암환자의 수면양상 및 수면에 영향을미치는 요인", Asian Oncology Nursing, 16(1), pp.30~37 (2016), 대한종양간호학회
- Nishiura M, "Assessment of sleep disturbance in lung cancer patients : relationship between sleep disturbance and pain, fatigue, quality of life, and psychological distress", Palliat Support Care, 13, pp.575~581 (2015)
- 김혜영, "유방암 환자의 항암화학요법으로 인한 말초신경병증과 삶의 질", Asian Oncology Nursing, 13(4), pp.222~230 (2013), 대한종양간호학회
- 김경덕, "항암화학요법을 받는 췌장암 환자의 통증, 수면장애, 피로가 삶의 질에 미치는 영향", Asian Oncology Nursing, 12(2), pp.117~124 (2012), 대한종양간호학회[DOI]