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소아 진정 치료 시 구강 점막 하와 비점막 Midazolam 투여의 행동 반응 비교

Comparison of behavioral response between intranasal and submucosal midazolam adminstration

정상혁|백광우|김윤희
대한소아치과학회 (The Korean Academy Of Pediatric Dentistry)|2008.08|대한소아치과학회지 (Journal of the Korean academy of pediatric dentistry)|제35권 제3호|pp. 427-436

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참고문헌

키워드

Chloral hydrateSedation진정법Submucosal midazolamIntranasal midazolam점막하 미다졸람비강내 미다졸람크로랄 하이드레이트
주제분류치의학

초록

Purpose. The objective of this study was to evaluate the behavioral response and assess the effectiveness of additional intranasal (IN) and submucosal (SM) administration of midazolam during pediatric sedation for dental procedure. Material and methods. Thirty-three cases of healthy (ASAⅠ), uncooperative children aged from 24 to 72 month old at pediatric dental clinic of Ewha Womans University Hospital were selected for this study. Children received oral chloral hydrate 50 mg/kg with hydroxyzine 1.0 mg/kg. After waiting for 45 minutes, midazolam 0.2 mg/kg was administrated via IN route and via SM route randomly maintaining 50% of N2O. A pulse oximeter and a capnograph were used for measuring vital signs (SpO2, PR, RR, EtCO2) throughout the sedation. Behavioral response was evaluated as Quiet (Q), Crying (C), Movement (M) or Struggling (S) in every 2 minutes for 40 minutes. Results. There were also no statistically significant differences in vital signs of the two groups. The behavioral response for the first ten minutes during sedation was a statistically significant difference (P < 0.05) between the two groups. After the first ten minutes, it was revealed that there was no significant difference. Conclusion. This study demonstrated that the addition of IN midazolam to the combination of oral chloral hydrate with hydroxyzine and nitrous oxide/oxygen inhalation is as safe and effective as that of SM midazolam in pediatric sedation for dental procedure.

Abstract

Purpose. The objective of this study was to evaluate the behavioral response and assess the effectiveness of additional intranasal (IN) and submucosal (SM) administration of midazolam during pediatric sedation for dental procedure. Material and methods. Thirty-three cases of healthy (ASAⅠ), uncooperative children aged from 24 to 72 month old at pediatric dental clinic of Ewha Womans University Hospital were selected for this study. Children received oral chloral hydrate 50 mg/kg with hydroxyzine 1.0 mg/kg. After waiting for 45 minutes, midazolam 0.2 mg/kg was administrated via IN route and via SM route randomly maintaining 50% of N2O. A pulse oximeter and a capnograph were used for measuring vital signs (SpO2, PR, RR, EtCO2) throughout the sedation. Behavioral response was evaluated as Quiet (Q), Crying (C), Movement (M) or Struggling (S) in every 2 minutes for 40 minutes. Results. There were also no statistically significant differences in vital signs of the two groups. The behavioral response for the first ten minutes during sedation was a statistically significant difference (P < 0.05) between the two groups. After the first ten minutes, it was revealed that there was no significant difference. Conclusion. This study demonstrated that the addition of IN midazolam to the combination of oral chloral hydrate with hydroxyzine and nitrous oxide/oxygen inhalation is as safe and effective as that of SM midazolam in pediatric sedation for dental procedure.

참고문헌 (39)

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관련 논문AI추천

점막하 Midazolam의 병용투여 시 BIS 분석을 이용한 진정 평가김소영, 김윤희, 박미경, 백광우, 이영은, 정상혁대한소아치과학회 · 대한소아치과학회지2007 · 제34권 제1호미다졸람의 비강 내 추가투여가 소아의 경구 진정요법에 미치는 영향김지연, 박기태, 장수영대한소아치과학회 · 대한소아치과학회지2012 · 제39권 제1호소아 환자에서 미다졸람의 경구 투여와 근육 투여에의한 진정 효과의 비교 연구김종수, 민유진, 유승훈대한소아치과학회 · 대한소아치과학회지2006 · 제33권 제1호진정법을 이용한 치과 치료 시 소아 환자의 진정 후 반응에 대한 연구구정은, 백광우대한소아치과학회 · 대한소아치과학회지2009 · 제36권 제2호Midazolam의 경비투여와 경구투여시 진정효과에 대한 비교연구박헌동대한소아치과학회 · 대한소아치과학회지2004 · 제31권 제3호소아환자에서 midazolam 정주 및 아산화질소 흡입진정법 하 치과치료의 특성김영재, 김정욱, 김현태, 송지수, 신터전, 이상훈, 장기택, 현홍근대한소아치과학회 · 대한소아치과학회지2020 · 제47권 제1호

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