어린이와 어머니의 Streptococcus mutans 분포와 전이
DISTRIBUTION AND TRANSMISSION OF STREPTOCOCCUS MUTANS AMONG CHILDREN AND THEIR MOTHERS
0
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
최근 우리와 다른 민족 또는 다른 문화적 배경을 가진 사람들이 포함된 다문화가정이 증가하였고 그들에 대한 사회적 관심이 증가하고 있으나, 우리는 아직 이들의 구강상태에 대한 기초적인 자료도 없는 실정이다. 본 연구는 부모가 모두 한국인인가정과 다문화 가정에서, 어머니와 어린이의 구강 상태를 검사하고, polymerase chain reaction(PCR)을 이용하여 치아우식증의 주요 원인균인 Streptococcus mutans의 serotype 분포와 전이에 대한 실험을 통해 다음과 같은 결과를 얻었다. 1) 한국인 가정에서는, serotype c는 95%, serotype e, f, k는 10%의 비율로 나타났으며, 다문화가정을 대상으로 하였을때에는 serotype c는 68.8%, serotype e는 31.25%, serotype f는 43.75%, serotype k는 18.8%의 비율로 나타났다. 2) 어머니와 어린이 둘 다 serotype이 확인된 경우, 92.86%에서 어머니와 어린이가 하나 이상의 같은 serotype을 포함하는 것으로 나타났다. 3) 한 가지 serotype만 나타난 경우보다 두 종류 이상의 serotype이 확인된 경우에서 평균 S. mutans level이 높게 나왔으나 통계적으로 유의한 차이는 없었다(p>0.05). 4) 우식 위험이 높다고 볼 수 있는 S. mutans level 2를 기준으로 비교하였을 때, 각 그룹 간에 우식 위험도는 통계적으로유의한 차이가 없었다(p>0.05). 5) 그룹에 따른 serotype의 수, 우식 이환율, S. mutans level 간에는 유의한 상관관계가 없었다(p>0.05).
Abstract
Recently, the number of multi-cultural families have been on the rise for years in Korea. Although social concerns are on the increase, there is still no basic data of their oral health state. In this study, we examined the caries prevalence of mother-child pairs from some korean families and multi-cultural families, and collected some saliva from them. We evaluated Streptococcus mutans level and investigated the serotype distribution of Streptococcus mutans of them to confirm the transmission in mother-child pairs. As a results, to the Korean families, the percentages of serotype c, e, f, k were 95%, 10%, 10%, and 10%. And to the multi-cultural families, the percentages of serotype c, e, f, k were 68.8%, 31.25%, 43,75%, 18.8%. But, there is no significant relationship between the number of serotype per person, caries prevalence, and Streptococcus mutans level(p>0.05). In conclusion, there are differences of serotype distribution of Streptococcus mutans between the two families. Nevertheless, matching rate of more than one serotype between mother and their child was high (92.86%). So,vertical transmission of Streptococcus mutans in mother-child pairs could be demonstrated.
참고문헌 (31)
- Loesche WJ, "Role of Streptococcus mutans in human dental decay", Microbiol Rev, 50, pp.353~380 (1986)
- Hamada S, "Biology, immunology, and cariogenicity of Streptococcus mutans", Microbial Rev, 44, pp.331~384 (1980)
- Nakano K, "Demonstration of Streptococcus mutans with a cell wall polysaccharide specific to a new serotype, k, in the human oral cavity", J Clin Microbiol, 42, pp.198~202 (2004)
- Shibata Y, "Analysis of loci required for determination of serotype antigenicity in Streptococcus mutans and its clinical utilization", J Clin Microbial, 41, pp.4107~4112 (2003)
- Keyes PH, "Factors influencing the initiation, transmission and inhibition of dental caries. In : Mechanisms of Hard Tissue Destruction", pp.261~283 (1963), Academy Press, NY
- Tanzer JM, "The microbiology of pri- mary dental caries in humans", J Dent Educ, 65, pp.1028~1037 (2001)
- Caufield PW, "Initial acquisition of mutans streptococci by infants : evidence for a discrete window of infectivity", J Dent Res, 72, pp.37~45 (1993)
- Brailsford S, "The microflora of the erupting first permanent molar", Caries Res, 39, pp.78~84 (2005)
- Wan AK, "A Longitudinal study of Streptococcus mutans colonization in infants after tooth eruption", J Dent Res, 82, pp.504~508 (2003)
- Wan AK, "Oral colonization of Streptococcus mutans in six-month-old predentate infants", J Dent Res, 80, pp.2060~2065 (2001)
- Law V, "A longitudinal controlled study of factors associated with Mutans streptococci infection and caries lesion initiation in children 21 to 72 months old", Pediatr Dent, 28(1), pp.58~65 (2006)
- Berkowitz R, "Mutans streptococci : Acquisition and transmission", Pediatr Dent, 28, pp.106~109 (2006)
- Li Y, "The fidelity of initial acquisition of Mutans streptococci from their mothers", J Dent Res, 74, pp.681~685 (1995)
- Davey AL, "Multiple types of the bacterium Streptococcus mutans in the human mouth and their intra-family transmission", Arch Oral Biol, 29(6), pp.453~460 (1984)
- Berkowitz RJ, "Maternal salivary levels of Streptococcus mutans and primary oral infection of infants", Arch Oral Biol, 26, pp.147~149 (1981)
- Li Y, "Characterization of maternal mutans streptococci transmission in an American African population", Dent Clin North Am, 47, pp.87~101 (2003)
- Li Y, "The fidelity of initial acquisition of mutans streptococci from their mothers", J Dent Res, 74, pp.681~685 (1995)
- Casamassimo PS, "Maternal oral health", Dent Clin North Am, 45, pp.469~478 (2001)
- Kohler B, "Influence of caries experience in their children", Arch Oral Biol, 39, pp.907~911 (1994)
- Keene HJ, "Distribution of Streptococcus mutans biotypes in five human populations", J Dent Res, 86, pp.35~42 (1977)
- Hirasawa M, "A new selective medium for Streptococcus mutans and the distribution of S. mutans and S. sobrinus and their serotypes in dental plaque", Caries Res, 37, pp.212~217 (2003)
- Nakano K, "Development of a PCR method for rapid identification of new Streptococcus mutans serotype k strains", J Clin Microbiol, 42, pp.4925~4930 (2004)
- Masuda N, "Longitudinal survey of the distribution of various serotypes of Streptococcus mutans in infants", J clin Microbiol, 10, pp.497~502 (1979)
- Hamada S, "Isolation and serotyping of Streptococcus mutans from teeth and feces of children", J clin Microbiol, 11, pp.314~318 (1980)
- 하윤문, "치아우식증환자와 치아정상인의 치태()에서 분리한 Streptococcus mutans의 혈청형 분포에 관한 조사연구", 대한미생물학회, 18(1), pp.23~30 (1983)
- Huis in’t Veld JH, "Streptococcus mutans and dental caries in humans : A bacteriological and immunological study", Antonie van Leeuwen-hoek, 45(1), pp.25~33 (1979)
- Hamada S, "Dental caries induction in experimental animals by clinical strains of Streptococcus mutans isolated from Japanese children", Microbiol Immunol, 22(6), pp.301~314 (1978)
- Seki M, "Effect of mixed Mutans streptococci colonization on caries development", Oral Microbiol Immunol, 21(1), pp.47~52 (2006)
- Seki M, "Effect of mixed mutans streptococci colonization on caries development", Oral Microbiology Immunology, 21, pp.47~52 (2006)
- 김추성, "단클론항체를 이용한 타액 내 Streptococcus mutans 수준의 측정", 대한소아치과학회지, 37(2), pp.186~192 (2010), 대한소아치과학회
- 임수민, "소아와 성인의 타액 내 AgⅠ", Ⅱ 특이 IgA 와 우식경험도의 관계, 2008, pp.35(4), 671~676[DOI]