폴리비닐알코올 기반 고분자 불소 함유 테이프의 구강 내 불소 유리 성능 평가
EVALUATION OF FLUORIDE-RELEASING CAPACITY FROM POLYVINYL ALCOHOL POLYMER TAPE SUPPLEMENTED WITH NAF IN ORAL CAVITY
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초록
연구의 목적은 인체 안정성이 입증된 고분자제제인 폴리비닐알코올(PVA, polyvinyl alcohol)로 얇은 박막을 제조하고 불화나트륨(NaF)을 첨가하여 불소를 함유한 고분자 접착 테이프(NaF-PVA)를 개발하여 피실험자의 구강 내에 도포 후 잔류하는 불소농도를 측정하였다. 이를 통해 제제 도포 전후의 타액 내 불소농도를 분석하여 불소를 함유한 고분자 접착 테이프의 치아우식증 예방효과를 간접적으로 평가하였다. 불소겔(60seconds taste, Group 1), 불소바니쉬(FluoroDose varnish,Group 2)와 불소를 함유한 고분자 접착 테이프(NaF-PVA, Tiral product, Group 3)를 각각 15명씩 상악 치아 12개의 순면에 도포 후, 1시간, 3시간, 6시간, 12시간, 24시간, 48시간 후 비자극성 타액 내 불소농도를 불소이온전극을 이용하여 측정하였다. 도포 후 3시간까지 세 군 모두 불소제제 도포 전 농도보다 유의하게 높은 불소농도를 보였으며 3군의 경우 도포 후 6시간에서도 불소제제 도포 전 농도보다 유의하게 높은 불소농도를 보였다(p < 0.05). 도포 후 6시간에서 3군은 1군과 2군보다 유의하게 높은 불소농도를 보였고 (p < 0.05), 1군과 2군 사이의 유의한 차이는없었다(p > 0.05).
Abstract
The purpose of this study is to investigate fluoride release in the oral cavity from polymer adhesive tape which is NaF coated PVA. 45 healthy adults were divided into 3 groups by the type of topical fluoride applied: 60seconds taste APF gel (group 1), FluoroDose varnish (group 2) and NaF-PVA (group 3). Topical fluoride was applied to the facial surface of maxillary 12 teeth and unstimulated whole saliva was collected to measure fluoride release after 1, 3, 6, 12, 24, and 48 hours. Fluoride-sensitive electrode was used for measuring the fluoride concentration in the saliva samples. All three groups showed significantly higher value for fluoride concentration than the baseline after 1 and 3hours (p < 0.05). After 6 hours, group 3 showed significantly higher fluoride concentration than the baseline (p < 0.05) and also showed significantly higher value for fluoride concentration than group 1 and group 2. Between group 1 and group 2, however, there was no significant difference statistically with respect to fluoride concentration value (p > 0.05).
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