Synergistic Effects of Cisplatin-epigel and Interstitial KTP Laser Treatment on a Xenografted Squamous Cell Carcinoma
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background and Objectives Cisplatin is an important chemotherapy drug for the treatment of head and neck cancer. Interstitial laser treatment (ILT) has cosmetic utility and is very important for maintaining the function of the head and neck after cancer treatment. This study examined the synergistic effects of locally injected cisplatin-epigel and high fever induced by an interstitial potassium titanyl phosphate (KTP) laser treatment on a xenografted human Heinz squamous cell carcinoma. Materials and Methods SNU-1041 (107 cells/0.1 ml) cells were xenografted into the back of nude mice by subcutaneous injection. The ILT group (n = 10) was treated with a KTP laser (1 J/mm3) through a cylindrical diffuser tip inserted into the tumor, monitoring the temperature at 43-45°C. In the combined treatment group (n = 10), local hyperthermia was induced by intratumoral injection of 100-200 μg of cisplatin into a collagen-based gel carrier (cisplatin-epigel), which was released slowly four hours before ILT. After four weeks of follow-up, the treated tumors were evaluated for tumor remission and volume change. Results Eight (80%) of the combined group showed complete tumor remission at the four-week follow-up, whereas only three (30%) of the ILT group showed remission (30%) (p < 0.01). Conclusion The current study has shown the synergistic effects of a local cisplatin injection and high fever from ILT on a xenografted human Heinz squamous cell carcinoma.
Abstract
Background and Objectives Cisplatin is an important chemotherapy drug for the treatment of head and neck cancer. Interstitial laser treatment (ILT) has cosmetic utility and is very important for maintaining the function of the head and neck after cancer treatment. This study examined the synergistic effects of locally injected cisplatin-epigel and high fever induced by an interstitial potassium titanyl phosphate (KTP) laser treatment on a xenografted human Heinz squamous cell carcinoma. Materials and Methods SNU-1041 (107 cells/0.1 ml) cells were xenografted into the back of nude mice by subcutaneous injection. The ILT group (n = 10) was treated with a KTP laser (1 J/mm3) through a cylindrical diffuser tip inserted into the tumor, monitoring the temperature at 43-45°C. In the combined treatment group (n = 10), local hyperthermia was induced by intratumoral injection of 100-200 μg of cisplatin into a collagen-based gel carrier (cisplatin-epigel), which was released slowly four hours before ILT. After four weeks of follow-up, the treated tumors were evaluated for tumor remission and volume change. Results Eight (80%) of the combined group showed complete tumor remission at the four-week follow-up, whereas only three (30%) of the ILT group showed remission (30%) (p < 0.01). Conclusion The current study has shown the synergistic effects of a local cisplatin injection and high fever from ILT on a xenografted human Heinz squamous cell carcinoma.
참고문헌 (24)
- Castro DJ, "Ultrasound-guided, minimally invasive therapy for recurrent head and neck carcinomas", Oper Tech Otolayngol Head Neck Surg, 5, pp.259~266 (1994)
- Castro DJ, "Minimally invasive palliative tumor therapy guided by imaging techniques : the UCLA experience", J Clin Laser Med Surg, 12, pp.65~73 (1994)
- Kusumoto T, "Hyperthermia and platinum complexes : time between treatments and synergy in vitro and in vivo", Int J Hyperthermia, 11, pp.575~586 (1995)
- Kitamura K, "Synergistic effects of intratumor administration of cisdiamminedichloroplatinum(II)combined with local hyperthermia in melanoma bearing mice", J Surg Oncol, 51, pp.188~194 (1992)
- Yano T, "Additive effects of cepharanthin in CDDP", hyperthermia combination therapy against transplantable human esophageal cancer in nude mice, 1994, pp.29, 525~528
- Uehara M, "Experimental study of combined hyperthermic and photodynamic therapy on carcinoma in the mouse", J Oral Maxillofac Surg, 54, pp.729~736 (1996)[DOI]
- Hettinga JV, "Reduction of cellular cisplatin resistance by hyperthermia--a review", Int J Hyperthermia, 13, pp.439~457 (1997)
- Fisher GA, "Enhancement of cis-platinum(II) diamminedichloride cytotoxicity by hyperthermia", Proceedings of the 3rd International Symposium: Cancer Therapy by Hyperthermia, Drugs, and Radiation, pp.255~257 (1980), National Cancer Institute
- Davidson BS, "Collagen matrix cisplatin prevents local tumor growth after margin-positive resection", J Surg Res, 58, pp.618~624 (1995)
- Graeber IP, "Combined intratumor cisplatinum injection and Nd : YAG laser therapy", Laryngoscope, 109, pp.447~454 (1999)
- Paiva MB, "Cisplatinum and interstitial laser therapy for advanced head and neck cancer : a preclinical study", Lasers Surg Med, 21, pp.423~431 (1997)
- Kim KH, "Establishment and characterization of cell lines derived from squamous cell carcinoma of the head and neck", Korean J Head Neck Oncol, 12, pp.181~187 (1996)
- Schulze H, "Transurethral ultrasound-guided laser-induced prostatectomy : clinical outcome and data analysis", Urology, 45, pp.241~247 (1995)
- Blackwell KE, "Real-time intraoperative ultrasonography as a monitoring technique for Nd : YAG-laser palliation of unresectable head and neck tumors : initial experience", Laryngoscope, 103, pp.559~564 (1993)
- Blackwell KE, "MRI and ultrasound guided interstitial Nd : YAG laser phototherapy for palliative treatment of advanced head and neck tumors : clinical experience", J Clin Laser Med Surg, 11, pp.7~14 (1993)
- Celine DG. Abueva, "Photo-triggered Theranostic Nanoparticles in Cancer Therapy", Medical Lasers, 10(1), pp.7~14 (2021), 대한의학레이저학회[DOI]
- Saxton RE, "Interstitial laser and chemotherapy combined for treatment of human squamous cell carcinoma", SPIE 2970: Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VII. Proceedings of the BiOS '97Part of Photonics West, pp.158~165 (1997), SPIE
- Cho S, "Treatment of epidermal pigmented lesions with 578 nm yellow laser", Med Laser, 4, pp.35~38 (2015)
- Chung PS, "Effect of photodynamic therapy in melanoma skin cancer cell line A375 : in vivo study", Med Laser, 3, pp.27~30 (2014)
- Burris HA 3rd, "Intratumoral cisplatin", epinephrine-injectable gel as a palliative treatment for accessible solid tumors : a multicenter pilot study, 1998, pp.118, 496~503
- Yu NY, "Response of murine tumors to matrix-associated cisplatin intratumoral implants", NCI Monogr, 6, pp.137~140 (1988)
- Krag DN, "Intralesional cis-diamminedichloroplatinum and purified collagen treatment of human metastatic malignancies : a feasibility study", J Surg Oncol, 43, pp.83~87 (1990)
- 문익준, "Review of the Current State of Medical Plasma Technology and its Potential Applications", Medical Lasers, 7(1), pp.1~5 (2018), 대한의학레이저학회[DOI]
- Baek SK, "Extended applications of laser for photothermal treatment", Med Laser, 3, pp.39~42 (2014)