소아와 성인의 타액 내 AgⅠ/Ⅱ 특이 IgA 와 우식경험도의 관계
The Relationship between the Salivary IgA against AgⅠ/Ⅱ of S. mutans and Dental Caries Experience among Children and Adults
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초록
치아 우식증은 감염성 질환의 하나로 치아우식의 원인균은 Streptococcus mutans(S. mutans)와 같은 mutans steptococci로 알려져 있다. S. mutans가 치면에 접착하여 군집을 형성하는 능력은 균독성에 중요한 역할을 하는데, AgⅠ/Ⅱ와 같 은 세포 표면의 섬유성 단백질을 매개로 한다. Secretory IgA는 타액이나 누∙비액, 초유, 그리고 폐나 소화기관의 분비액에서 선택적으로 다량 발견되는데 타액에서 secretory IgA는 S. mutans의 대사활동을 억제하고 치면으로의 부착을 방해한다. 이전의 몇몇 연구에서 S. mutans에 특이적 인 타액 내 IgA와 우식경험도는 역상관관계를 보인다고 발표하였다. 그러나 다른 연구에서 통계적 유의성이 없다고 보고하기 도 하였다. 본 연구의 목적은 소아, 성인의 치아우식증과 S. mutans의 AgⅠ/Ⅱ에 특이적인 타액 내 IgA와의 관계를 알기위한 것이 다. 이를 위해 소아(평균6세) 28명, 성인(20-30세) 18명을 대상으로 Group Ⅰ(deft index ≤ 3), Group Ⅱ(deft index ≥ 4), Group Ⅲ(DMFT index ≤ 3), Group Ⅳ(DMFT index ≥ 4)로 분류하였다. 그리고 caries resistant group(CR group, deft or DMFT index ≤ 3)과 caries susceptible group(CS group, deft or DMFT index ≥ 4)으로 분류하였다. S. mutans 수와 우식경험도 간에는 통계적으로 유의한 상관관계를 나타냈다. AgⅠ/Ⅱ 특이 salivary IgA titer는 Group Ⅲ이 Group Ⅱ보다 통계적으로 유의하게 더 컸으며 , CR group이 CS group보다 유의하게 크게 나타났다.
Abstract
AgI/II of Streptococcus mutans(S. mutans) is an important virulence factor that contributes to the pathogenesis of S. mutans-induced dental caries. In oral cavity, salivary IgA antibodies act as safeguards against enormous challenges from oral bacteria. IgA antibodies inhibit adherence of cariogenic microorganisms to hard surfaces. Analysis of salivary IgA against AgI/II can be very useful diagnostic and powerful communication tools to the dental caries The purpose of this study was to investigate correlation between salivary AgI/II specific IgA and incidence of dental caries among children and young adults. Subjects consisted of 28 children and 18 adults. They were assigned to four groups : Group Ⅰ(deft index ≤ 3), Group Ⅱ(deft index ≥ 4), Group Ⅲ(DMFT index ≤ 3), Group Ⅳ(DMFT index ≥ 4) and they was divided two groups into caries resistant group and caries susceptible group. The study group were examined caries activity and their salivary IgA was evaluated by enzyme-linked immunosorbent assay. The results are as follows : 1. There was a positive correlation between the number of S. mutans and caries activity. 2. The titer of salivary IgA against the AgI/II was significantly higher in caries resistant group than caries susceptible group(p<0.01). 3. The titer of salivary IgA against the AgI/II in Group Ⅲ was significantly higher than GroupⅡ(p<0.05).
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