미숙아 망막병증의 예측 인자로써의 혈청 IGF-I의 유의성
The Significance of Serum IGF-I Level as a Predictor of Retinopathy of Prematurity
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
본 연구는 혈청 IGF-I 농도와 미숙아 망막병증의발생 및 중등도와의 관련성을 확인하기 위해 시행하였다. 출생 직후, 생후 14일, 21일의 IGF-1 농도는 미숙아 망막병증을 진단 받은 환아에서 유의한 차이를 보이지 않았고 초기 체중 변화 또한 유의한 차이를 보이지 않았다. IGF-1 농도와 초기 체중 증가는 미숙아 망막병증의 예측 인자로써 통계학적인 유의성을 보이지않아 정기적인 안과 검사를 대체할 수는 없는 것으로보여진다.
Abstract
Objectives: Low levels of serum insulin-like growth factor (IGF-I) in preterm infants have been to predict the risk and severity of retinopathy of prematurity (ROP), and other severe perinatal morbidities. This study aimed to find the relation between the level of serum IGF-I and the development and severity of ROP in Korean preterm infants. Methods: A retrospective study was carried out on 73 premature infants who admitted to NICU of Kyungpook National University Hospital from August 2008 to June 2011. We measured the level of serum IGF-I at birth, 14 days, and 21 days. The ophthalmologic examinations were performed once or twice a week, depending on the severity, which was started by the later of 31~33 weeks’postmenstrual age or 4~6 weeks after birth. Results: The level of serum IGF-I at birth is correlated with birth weight. The mean serum IGFI values at birth is statistically different between appropriate for gestational age infants and small for gestational age, also between infants with and without morbidities, but not statistically different between infants with ROP and infants without ROP. The levels of serum IGF-I at 14 days and 21days after birth also are not different significantly in infants with ROP. The level of serum IGF-I at birth is not related to the time to recover birth weight, and severity of ROP. Conclusions: The level of serum IGF-1 and early weight gain do not have significance as a predictor of ROP in this study. It needs to perform regular and repetitive ophthalmologic examinations.
참고문헌 (23)
- Bardin C, "Outcome of small-for-gestational age and appropriate-forgestational age infants born before 27 weeks of gestation", Pediatrics, 100, pp.1~5 (1997)
- Chen J, "Retinopathy of prematurity", Angiogenesis, 10(2), pp.133~140 (2007)
- Darlow BA, "Prenatal risk factors for severe retinopathy of prematurity among very preterm infants of the Australian and New Zealand Neonatal Network", Pediatrics, 115, pp.990~996 (2005)
- Drencer KA, "Aggressive posterior retinopathy of prematurity", Retina, 30(4 Suppl), pp.S37~S40 (2010)
- Early Treatment of Retinopathy of Prematurity Cooperative Group, "Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial", Arch Ophthalmol, 121, pp.1684~1696 (2003)
- Gluckman PD, "Clinical review 68: the endocrine regulation of fetal growth in late gestation: the role of insulin-like growth factors", J Clin Endocrinol Metab, 80, pp.1047~1050 (1995)
- Hellström A, "Postnatal serum insuin-like growth factor I deficiency is associated with retinopathy of prematurity and other complications of premature birth", Pediatrics, 112(5), pp.1016~1020 (2003)
- Hellström A, "Early weight gain predicts retinopathy of preterm infants: new, simple, efficient approach to screening", Pediatrics, 123(4), pp.e638~e645 (2009)
- Hellström A, "New sights into the development of retinopathy of prematurity-importance of early weight gain", Acta Paediatr, 99(4), pp.502~508 (2010)
- Iniguez G, "Longitudinal changes in insulin- like growth factor-I, insulin sensitivity, and secretion from birth to age three years in smallfor- gestational-age children", J Clin Endocrinol Metab, 91, pp.4645~4649 (2006)
- International Committee for the Classification of Retinopathy of Prematurity, "The international classification of retinopathy of prematurity revisited", Arch Ophthalmol, 123(7), pp.991~999 (2005)
- Kajantie E, "Markers of type I and type III collagen turnover, insulin-like growth factors, and their binding proteins in cord plasma of small premature infants: relationship with fetal growth, gestational age, preeclampsia, and antenatal glucocorticoid treatment", Pediatr Res, 49, pp.481~489 (2001)
- Karna P, "Retinopathy of prematurity and risk factors: a prospective cohort study", BMC Pediatr, 5(1), pp.18~ (2005)
- Kleberg A, "Lower stress responses after newborn individualized developmental care and assessment program during eye screening examinations for retinopathy or prematurity: a randomized study", Pediatrics, 121(5), pp.1267~1278 (2008)
- Le Roith D, "Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors", N Engl J Med, 336, pp.633~640 (1997)
- Löfqvist C, "Longitudinal postnatal weight and insulin-like growth factor I measurements in the prediction of retinopathy of prematurity", Arch Ophthalmol, 124, pp.1711~1718 (2006)
- Löfqvist C, "Validation of a new retinopathy of prematurity screening method monitoring longitudinal postnatal weight and insulinlike growth factor I", Arch Ophthalmol, 127(5), pp.622~627 (2009)
- Ohkawa N, "IGF-I, leptin and active ghrelin in very low birth weight infants during the first 8 weeks of life", Acta Paediatr, 99(1), pp.37~41 (2010)
- "Outcomes in British Columbia: a 10-year analysis", J Perinatol, 28(8), pp.566~572 (2008)
- Reynolds JD, "CRYO-ROP and LIGHTROP Cooperative Study Groups. Evidence-based screening criteria for retinopathy of prematurity: natural history data from the CRYO-ROP and LIGHT-ROP studies", Arch Ophthamol, 120(11), pp.1470~1476 (2002)
- Schiariti V, "Severe retinopathy of prematurity and visual Smith LE. Pathogenesis of renitopathy or prematurity", Growth Horm IGF Res, 14, pp.S140~S144 (2004)
- Wu C, "Logitudinal postnatal weight measurements for the prediction of retinopathy of prematurity", Arch Ophthalmol, 128(4), pp.443~447 (2010)
- Wu C, "Importance of early postnatal weight gain for normal retinal angiogenesis in very preterm infants: a multicenter study analyzing weight, velocity deviations for the prediction of retinopathy of prematurity", Arch Ophthalmol, 243 (2012)[DOI]