전자선치료 시 3D 프린터로 제작한 환자 맞춤형 차폐체의 유용성 평가
Evaluation of the Usefulness of Patient Customized Shielding Block Made with 3D Printer in the Skin Cancer Electron Beam Therapy
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초록
In order to improve and supplement the shielding method for electron beam treatment, we designed a patient- specific shielding method using a 3D printer, and evaluated the usefulness by comparing and analyzing the distribution of electron beam doses to adjacent organs. In order to treat 5 cm sized superficial tumors around the lens, a CT Simulator was used to scan the Alderson Rando phantom and the DICOM file was converted into an STL file. The converted STL file was used to design a patient-specific shield and mold that matched the body surface contour of the treatment site. The t hickness o f the shield was 1 cm and 1.5 cm, a nd the mold was p rinted u sing a 3D printer, and t he patient customized shielding block (PCSB) was fabricated with a cerrobend alloy with a thickness of 1 cm and 1.5 cm. The dosimetry was performed by attaching an EBT3 film on the surface of the Alderson Rando phantom eyelid and measuring the dose of 6, 9, and 12 MeV electron beams on the film using four shielding methods. Shielding rates were 83.89%, 87.14%, 87.39% at 6, 9, and 12 MeV without shielding, 1 cm (92.04%, 87.48%, 86.49%), 1.5 cm (91.13%, 91.88% with PSCB), 92.66%) The shielding rate was measured as 1 cm (90.7%, 92.23%, 88.08%) and 1.5 cm (88.31%, 90.66%, 91.81%) when the shielding block and the patient-specific shield were used together. PCSB fabrication improves shielding efficiency over conventional shielding methods. Therefore, PSCB may be useful for clinical application.
Abstract
In order to improve and supplement the shielding method for electron beam treatment, we designed a patient- specific shielding method using a 3D printer, and evaluated the usefulness by comparing and analyzing the distribution of electron beam doses to adjacent organs. In order to treat 5 cm sized superficial tumors around the lens, a CT Simulator was used to scan the Alderson Rando phantom and the DICOM file was converted into an STL file. The converted STL file was used to design a patient-specific shield and mold that matched the body surface contour of the treatment site. The t hickness o f the shield was 1 cm and 1.5 cm, a nd the mold was p rinted u sing a 3D printer, and t he patient customized shielding block (PCSB) was fabricated with a cerrobend alloy with a thickness of 1 cm and 1.5 cm. The dosimetry was performed by attaching an EBT3 film on the surface of the Alderson Rando phantom eyelid and measuring the dose of 6, 9, and 12 MeV electron beams on the film using four shielding methods. Shielding rates were 83.89%, 87.14%, 87.39% at 6, 9, and 12 MeV without shielding, 1 cm (92.04%, 87.48%, 86.49%), 1.5 cm (91.13%, 91.88% with PSCB), 92.66%) The shielding rate was measured as 1 cm (90.7%, 92.23%, 88.08%) and 1.5 cm (88.31%, 90.66%, 91.81%) when the shielding block and the patient-specific shield were used together. PCSB fabrication improves shielding efficiency over conventional shielding methods. Therefore, PSCB may be useful for clinical application.
참고문헌 (22)
- Group IMRTCW, "Intensity-modulated radiotherapy : Current status and issues of interest", International Journal of Radiation Oncology, 51(4), pp.880~914 (2001)
- Jette D, "Electron dose calculation using multiple‐scattering theory : Evaluation of a new model for inhomogeneities", Medical Physics, 19(5), pp.1241~1254 (1992)
- Verhaegen F, "Backscatter towards the monitor ion chamber in high-energy photon and electron beams : charge in tegration versus Monte Carlo simulation", Physics in Medicine & Biology, 45(11), pp.3159~ (2000)
- Khan FM, "Clinical electron‐beam dosimetry: report of AAPM radiation therapy committee task group No. 25", Medical physics, 18(1), pp.73~109 (1991)
- Bentel GC, "Treatment planning and dose calculation in radiation oncology" (2014), Elsevier
- Sharma S, "Surface dose perturbation due to air gap between patient and bolus for electron beams", Medical Physics, 20(2), pp.377~378 (1993)
- Kong M, "An investigation of central axis depth dose distribution perturbation due to an air gap between patient and bolus for electron beams", Australasian Physics & Engineering Sciences in Medicine, 30(2), pp.111~ (2007)
- Khan Y, "Clinical and dosimetric implications of air gaps between bolus and skin surface during radiation therapy", Journal of Cancer Therapy, 4(7), pp.1251~ (2013)
- Dubey A, "Using optical scanner and 3-dimensional printer technology to create lead shielding for radiation therapy of facial skin cancer with low-energy photons: An exciting innovation", International Journal of Radiation Oncology, 96(2), pp.E712~E713 (2016)
- Yeung W, "Current tools of radiation therapy in treatment of skin cancer", Hong Kong Journal of Dermatology & Venereology, 17(2), pp.79~86 (2009)
- Ouhib Z, "Aspects of dosimetry and clinical practice of skin brachytherapy : The American Brachytherapy Society working group report", Brachytherapy, 14(6), pp.840~858 (2015)
- Fuller SM, "Application of 3-dimensional printing in hand surgery for production of a novel bone reduction clamp", The Journal of Hand Surgery, 39(9), pp.1840~1845 (2014)
- Dong Z, "Application of 3-dimensional printing technology to Kirschner wire fixation of adolescent condyle fracture", Journal of Oral and Maxillofacial Surgery, 73(10), pp.1970~1976 (2015)
- 노경석, "Mixing chamber를 사용하여 그라데이션 색상을 구현하기 위한 G-code 생성기 개발", 한국CDE학회 논문집, 22(1), pp.10~17 (2017), 한국CDE학회[DOI]
- Jung SM, "A Study on Developing Customized Bolus using 3D Printers", The Journal of Korean Society for Radiation Therapy, 27(1), pp.61~71 (2015)
- Devic S, "Accurate skin dose measurements using radiochromic film in clinical applications", Medical Physics, 33(4), pp.1116~1124 (2006)
- Quach K, "Measurement of radiotherapy x‐ray skin dose on a chest wall phantom", Medical Physics, 27(7), pp.1676~1680 (2000)
- 한상현, "의료용 방사성동위원소의 종류에 따른 비스무트의 차폐율 평가", 한국융합학회논문지, 9(7), pp.87~93 (2018), 한국융합학회[DOI]
- "Radiation Therapeutics" (2016), Chung-Gu Publishier
- 이승훈, "6 MeV 전자선 치료 시 차폐물질로서 알루미늄, 구리, 납", 한국콘텐츠학회 논문지, 14(2), pp.457~466 (2014), 한국콘텐츠학회[DOI]
- Lee SH, "A study on the dose variation according to atomic number and field size of shielding materials in MeV electron beam", Korean Journal of Radiation Therapy, 25(2), pp.145~151 (2013)
- Arenas M, "Individualized 3D scanning and printing for non-melanoma skin cancer brachytherapy : A financial study for its integration into clinical workflow", Journal of Contemporary Brachytherapy, 9(3), pp.270~ (2017)