흰쥐 난자형성 세포의 알리인 방어효과
Radioprotection of Alliin in Oogenesis Cells of a White Rat
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Oogenesis process of ovary produces a lot of undifferentiated cells. Especially, the radiation exposure of early immature cells in the process of growth to oocyte causes serious disabilities. This study examined the radiation damage mechanism of undifferentiated cells and organelles in oogenesis process, and the radioprotection after injection of alliin. The ultrastructure after 7Gy X-ray irradiation on the white rat was observed in the experiment. The results is as follows. It was observed that the nucleus membrane of an oogonium was damaged and vacuolated in the several parts after 15 days of irradiation. The damage of mitochondria membrane and flow in cytoplasm after 20 and 30 days was found in the oogonium. After 40 days observation, peroxidation of fat droplets was found and organelles were tangled each other in ovary tissue. The partial damage of nuclear membrane in oogonium past 15 days after injection of alliin was found, but decreased remarkably. Mitochondria, Golgi body, and rough endoplasmic reticulum were also clearly observed, therefore, radioprotection effects in alliin was confirmed partially.
Abstract
Oogenesis process of ovary produces a lot of undifferentiated cells. Especially, the radiation exposure of early immature cells in the process of growth to oocyte causes serious disabilities. This study examined the radiation damage mechanism of undifferentiated cells and organelles in oogenesis process, and the radioprotection after injection of alliin. The ultrastructure after 7Gy X-ray irradiation on the white rat was observed in the experiment. The results is as follows. It was observed that the nucleus membrane of an oogonium was damaged and vacuolated in the several parts after 15 days of irradiation. The damage of mitochondria membrane and flow in cytoplasm after 20 and 30 days was found in the oogonium. After 40 days observation, peroxidation of fat droplets was found and organelles were tangled each other in ovary tissue. The partial damage of nuclear membrane in oogonium past 15 days after injection of alliin was found, but decreased remarkably. Mitochondria, Golgi body, and rough endoplasmic reticulum were also clearly observed, therefore, radioprotection effects in alliin was confirmed partially.
참고문헌 (20)
- Hall EJ, "Radiobiology for the Radiologist" (2006), Lippincott Willams & Wilkins
- Ji TJ, "The Study of Radiation Damage Mechanism on Ultra-Structures of Leukocytes and Platelets in Rat Cells", Spectroscopy Letters, 45, pp.48~54 (2012)
- 지태정, "알리인 투여 후 혈소판의 방사선 방어기전 연구", 방사선기술과학, 33(3), pp.185~191 (2010), 대한방사선과학회
- 지태정, "방사선 피폭 시 간세포의 손상 기전과 알리인의 방어효과", 방사선기술과학, 39(4), pp.623~630 (2016), 대한방사선과학회[DOI]
- Park YS, "Radiology", pp.177~180 (2016), Jungmunkag
- Stusrt Ira Fox, "Human Physiology" (2004), Mc Graw Hill
- 윤철호, "방사선 조사선량에 따른 생쥐 난소의 형태학적 변화", 방사선방어학회지, 32(4), pp.140~156 (2007), 테스트학회
- Yoon CH, "Ultrastructural Study of Mouse Ovary under X-ray Irradiation", J of Radiological Science and Technology, 28(3), pp.249~254 (2005)
- David S, "Hole’s Human Anatomy & Physiology" (2007), Mc Graw Hill
- 지태정, "프로폴리스 복강 주사 후 소장 흡수상피조직의 방사선 손상 기전과 방어효과", 한국콘텐츠학회 논문지, 10(7), pp.297~304 (2010), 한국콘텐츠학회
- 이지훈, "프로폴리스 섭식이 X-선에 의해 손상된 랫드의 여러 조직에 미치는 영향", 방사선방어학회지, 32(2), pp.51~57 (2007), 테스트학회
- Kim DJ, "The effect of red Ginseng extracts on antioxidant enzyme activities and lipid peroxidation of the kidney in postirradiated mice", Korean J Ginseng Sci, pp.25~31 (1994)
- Salman H, "Effect of a garlic derivative(alliin)on peripheral blood cell immune responses", Int J Immunopharmacol, 21(9), pp.589~597 (1999)
- Srivastava KC, "Effects of a garlic-derived principle(ajoene)on agregation and arachidonic acid metabolism in human blood platelets", Prostaglandins Leukot Essent Fatty Acids, 49(2), pp.587~595 (1993)
- Ali M, "Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet", Prostaglandins Leukot Essent Fatty Acids, 62(4), pp.253~259 (2000)
- A survey of compounds from the antiradiations drug development program of the US Army Medical Research and Development Command, "Sweeney TR.", Walter Reed Army Institute of Research, ~ (1979)
- Kim DY, "Radioprotective effect of ginseng components on antioxidant enzymes glutathione and lipid peroxidation of liver in γ-irradiation mice", Korean J Ginseng Sci, 22, pp.1~10 (1998)
- 윤철호, "6 MeV LINAC 방사선 조사에 의한 생쥐 난소조직의 미세구조 변화", Applied Microscopy, 33(2), pp.3~ (2003), 한국현미경학회
- Shier D, "HOLE’S Human Anatomy & Physiology", pp.900~911 (2007), Mc Graw Hill
- Sherwood, Lauralee, "Human Physiology", pp.695~700 (2004), Thomson Learning