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갑상샘 스캔 정량분석을 통한 갑상샘 섭취율 동시계측법 연구

Study of Simultaneous Counting of Thyroid Uptake with Quantitative Analysis of Thyroid Scans

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주제분류방사선과학

초록

Thyroid uptake measurements can be subject to measurement errors due to the scoping and positioning of the thyroid gland. To compensate for these limitations, the clinical utility of the thyroid simultaneous counting method as an alternative to thyroid uptake measurement was analyzed and evaluated experimentally through quantitative analysis of im- ages acquired after thyroid scanning. Experimental data were obtained using a Gamma camera (GE infinia), a thyroid up- take system (KOROID 1), and a thyroid neck phantom. Based on the thyroid uptake rate of 1-5% according to the proto- col of thyroid scan test (99mTcO4-, 370 MBq) in normal results, 99mTcO4- was set in the range of 3.7-18.5 MBq (Matrix: 256×256, Scan time: 1 min, collimator: pin hole, phantom-collimator distances: 7 ㎝). The acquired images were corrected for the attenuation of isotopes due to the set-up time and half-life by applying the Auto Region of interest (ROI) drawing system, and the significance of the experimental results was evaluated by Multiple linear regression analysis (SPSS, ver. 22, IBM). The thyroid uptake rate showed a significant correlation between the dose and the measured counts when using the thyroid uptake system equipment. Meanwhile, the quantitative analysis counts of phantom images using Gamma camera also showed a significant correlation. Thus confirmed that the correlation between these two experiments was statistically significant (P<0.05). The simultaneous counting protocol, which indirectly measures thyroid uptake from thyroid scans, is likely to be clinically relevant if complemented by additional studies with different variables in patients with thyroid disease.

Abstract

Thyroid uptake measurements can be subject to measurement errors due to the scoping and positioning of the thyroid gland. To compensate for these limitations, the clinical utility of the thyroid simultaneous counting method as an alternative to thyroid uptake measurement was analyzed and evaluated experimentally through quantitative analysis of im- ages acquired after thyroid scanning. Experimental data were obtained using a Gamma camera (GE infinia), a thyroid up- take system (KOROID 1), and a thyroid neck phantom. Based on the thyroid uptake rate of 1-5% according to the proto- col of thyroid scan test (99mTcO4-, 370 MBq) in normal results, 99mTcO4- was set in the range of 3.7-18.5 MBq (Matrix: 256×256, Scan time: 1 min, collimator: pin hole, phantom-collimator distances: 7 ㎝). The acquired images were corrected for the attenuation of isotopes due to the set-up time and half-life by applying the Auto Region of interest (ROI) drawing system, and the significance of the experimental results was evaluated by Multiple linear regression analysis (SPSS, ver. 22, IBM). The thyroid uptake rate showed a significant correlation between the dose and the measured counts when using the thyroid uptake system equipment. Meanwhile, the quantitative analysis counts of phantom images using Gamma camera also showed a significant correlation. Thus confirmed that the correlation between these two experiments was statistically significant (P<0.05). The simultaneous counting protocol, which indirectly measures thyroid uptake from thyroid scans, is likely to be clinically relevant if complemented by additional studies with different variables in patients with thyroid disease.

참고문헌 (38)

  1. Ur Rehman HA, "Performance analysis of machine learning algorithms for thyroid disease. Abdelmoneim Adam Mohamed", Patient Arabian Journal for Science and Engineering, 46, pp.9437~9449 (2021)[DOI]
  2. Gulec SA, "A joint statement from the American thyroid association, the european association of nuclear medicine, the European thyroid association, the society of nuclear medicine and molecular imaging on current diagnostic and theranostic approaches in the management of thyroid cancer", Thyroid, 31(7), pp.1009~1019 (2021)[DOI]
  3. Tuttle RM, "Controversies, consensus, and collaboration in the use of I-131 therapy in differentiated thyroid cancer : A joint statement from the american thyroid association, the european association of nuclear medicine, the society of nuclear medicine and molecular imaging, and the european thyroid association", Thyroid, 29, pp.461~470 (2019)[DOI]
  4. Cooper DS, "American thyroid association(ATA)guidelines taskforce on thyroid nodules and differentiated thyroid cancer. Revised American thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer", Thyroid, 19, pp.1167~1214 (2009)[DOI]
  5. Li J, "Thyroid hormone disruption by organophosphate esters is mediated by nuclear", membrane thyroid hormone receptors : In vitro, in vivo, and in silico studies, 2022, pp.56(7), 4241~4250
  6. Liu W, "Machine learning model for screening thyroid stimulating hormone receptor agonists based on updated datasets and improved applicability domain metrics", Chemical Research in Toxicology, 36(6), pp.947~958 (2023)[DOI]
  7. Shao W, "Cytoplasmic and nuclear forms of thyroid hormone receptor β1 are inversely associated with survival in primary breast cancer", Int J Mol Sci, 21(1), pp.330~ (2020)[DOI]
  8. Varghese J, "Radioiodine imaging and treatment in thyroid disorders", Neuroimaging Clinics of North America, 31(3), pp.337~344 (2021)[DOI]
  9. Taprogge J, "Setting up a quantitative spect imaging network for a european multi-centre dosimetry study of radioiodine treatment for thyroid cancer as part of the MEDIRAD project", EJNMMI Physics, 7, pp.61~ (2020)[DOI]
  10. Spanu A, "Neck lymph node metastasis detection in patients with differentiated thyroid carcinoma(DTC)in long-term follow-up : A 131I-SPECT", CT study, 2020, pp.20, 239~
  11. Currie GM, "Remodeling 99mTc-pertechnetate thyroid uptake : Statistical, machine learning, and deep learning approaches", Journal of Nuclear Medicine Technology, 50(2), pp.143~152 (2022)[DOI]
  12. Al-Muqbel KM, "Utility of 99mTechnetium pertechnetate thyroid scan and uptake in thyrotoxic patients : Jordanian experience", World Journal of Nuclear Medicine, 22(1), pp.7~14 (2022)[DOI]
  13. Ohba T, "Reconstruction of residents' thyroid equivalent doses from internal radionuclides after the fukushima daiichi nuclear power station accident", Scientific Reports, 10(1), pp.3639~ (2020)[DOI]
  14. Mariani G, "The role of nuclear medicine in the clinical management of benign thyroid disorders, part 2 : Nodular goiter, hypothyroidism and subacute thyroiditis", Journal of Nuclear Medicine, 62(7), pp.886~895 (2020)[DOI]
  15. Donohoe KJ, "Appropriate use criteria for nuclear medicine in the evaluation and treatment of differentiated thyroid cancer", Journal of Nuclear Medicine, 61(3), pp.375~396 (2020)[DOI]
  16. Alshahrani A, "Assessment of normal reference values for thyroid uptake of technetium-99m pertechnetate in a saudi population", Annals of Saudi Medicine, 41(2), pp.86~90 (2021)[DOI]
  17. Abdelhamed HM, "The utility of technetium-99m pertechnetate thyroid scintigraphy assessing thyroid", salivary ratio as an alternative to thyroid uptake percentage in evaluation of thyroid function, with establishing normal reference values of both parameters : Single egyptian center study, 2022, pp.43(12), 1181~1187
  18. Bednarczuk T, "European thyroid association guidelines for the management of iodine-based contrast media-induced thyroid dysfunction", European Thyroid Journal, 10(4), pp.269~284 (2021)[DOI]
  19. Schenke SA, "Distribution of functional status of thyroid nodules and malignancy rates of hyperfunctioning and hypofunctioning thyroid nodules in germany", Nuklearmedizin-NuclearMedicine, 61(5), pp.376~384 (2022)[DOI]
  20. Giovanella L, "Thyroid functional and molecular imaging", La Presse Médicale, 51(2), pp.104116~ (2022)[DOI]
  21. Verburg FA, "Differentiated thyroid cancer patients potentially benefitting from postoperative I-131 therapy : A review of the literature of the past decade", European Journal of Nuclear Medicine and Molecular Imaging, 47, pp.78~83 (2020)[DOI]
  22. Kim S, "Second primary malignancy risk in thyroid cancer and matched patients with and without radioiodine therapy analysis from the observational health data sciences and informatics", European Journal of Nuclear Medicine and Molecular Imaging, 49(10), pp.3547~3556 (2022)[DOI]
  23. 백성민, "갑상선암의 고용량 131I 치료 시 입원기간의 최적화방안 연구", 방사선기술과학, 33(3), pp.269~276 (2010), 대한방사선과학회
  24. Al-Jabri A, "Gender differences in estimating I-131 thyroid uptake from Tc-99m thyroid uptake for benign thyroid disease", The British Journal of Radiology, 94(1118), pp.20200700~ (2021)[DOI]
  25. Rumyantsev PO, "Thyroid scintigraphy in diagnosis of nodular and diffuse thyroid pathology", Clinical and Experimental Thyroidology, 15(4), pp.138~147 (2020)[DOI]
  26. Zampella E, "PET", CT in the management of differentiated thyroid cancer, 2021, pp.102(9), 515~523
  27. Al-Esaei AM, "Assessment of radiation exposure dose for nuclear medicine workers from 18F-FDG, 99mTc MDP, and 99mTc", Current Radiopharmaceuticals, 15(4), pp.320~326 (2022)[DOI]
  28. Naser AM, "Esophageal 99mTc-pertechnetate uptake mimicking an autonomous thyroid adenoma in a patient with subacute thyroiditis : A case report", Avicenna Journal of Medicine, 10(3), pp.125~127 (2020)[DOI]
  29. 박광훈, "분화성 갑상선암환자의 방사성 요오드 치료시 전리함과 Geiger-Muller계수관에서 방사선량률 측정값 비교", 방사선기술과학, 39(4), pp.565~570 (2016), 대한방사선과학회[DOI]
  30. Narkar RR, "Rapid differential diagnosis of thyrotoxicosis using T3", T4 ratio, FT3, Indian Journal of Endocrinology and Metabolism, pp.2021, 25(3)[DOI]
  31. Serrano B, "Quantitative analysis of 99mTc-pertechnetate thyroid uptake with a large-field CZT gamma camera : Feasibility and comparison between SPECT", CT and planar acquisitions, 2023, pp.10(1), 1~16
  32. JINMEIHUA, "Comparison of 99mTc Pertechnetate Thyroid Uptake Rates by Gamma Probe and Gamma Camera Methods for Differentiating Graves’ Disease and Thyroiditis", Nuclear Medicine and Molecular Imaging, 56(1), pp.42~51 (2022), 대한핵의학회[DOI]
  33. Clerc J, "Quantification of the thyroid scan(TS)and correlation to multiparametric ultrasounds(MPUS) : A textbook case of nuclear molecular imaging", Mdecine Nucléaire, 44(4), pp.216~230 (2020)[DOI]
  34. Weissinger M, "Follicular thyroid carcinoma in a hyperfunctioning thyroid nodule with suspicious sonomorphological features", Nuklearmedizin-NuclearMedicine, 59(6), pp.440~442 (2020)[DOI]
  35. Joji K, "Discordances between 99mTc and 131I uptake in two Graves' disease patients JQD. In: Japanese archive of cases conference of clinical nuclear medicine", Cases Conference of Clinical Nuclear Medicine, pp.5~9 (2022), NMJ
  36. Sookhaki S, "Design and fabrication of a pediatric thyroid phantom for use in radio-iodine uptake measurement, image quality control and dosimetry", Radiation Protection Dosimetry, 198(4), pp.238~245 (2022)[DOI]
  37. Mariani G, "The role of nuclear medicine in the clinical management of benign thyroid disorders, part 2 : Nodular goiter, hypothyroidism, and subacute thyroiditis", Journal of Nuclear Medicine, 62(7), pp.886~895 (2021)[DOI]
  38. Kim WB, "Interpretation and treatment of thyroid test results for practitioners", Korean Journal Medicine, 73(2), pp.777~784 (2007)[DOI]

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