3D 다세포 모델 내 매질에서 0.1 MeV 중성자빔 조사에 따른 흡수선량 평가

Abstract

This research aims to confirm the dependence of composition within 3D multicellular model when performing microdosimetry using Geant4-DNA. The region of interest (ROI) sufficiently included the target cell organelles and was randomly irradiated with 0.1 MeV neutrons. The absorbed dose was high in chemical composition similar to the real substances, according to the medium showed a large difference in the smaller the volume. For cytoplasm with dimensions 84×84×108 μm3 containing 27 cells, the absorbed dose showed biggest gap of 60%. Specific organelles such as nucleus, suggesting that choosing liquid water as the main component of cells remains a reasonable approximation for dosimetry in cellular volumes with ap- propriate cell gap. When measuring absorbed dose after particle irradiation with high linear energy transfer (LET), cell density and media are closely related and should be chosen carefully. The effect on the dose measurement increased when cells were closely packed in a small volume. The results of this study can be used to develop highly versatile, high-dimensional bio- logical tissue models and to predict the effects of ionizing radiation more precisely.