본문 바로가기
KERD
논문KCI 등재

뇌손상의 심각도와 뇌병변의 편재화가 외상성 뇌손상 환자의 인지기능에 미치는 영향

The Prognostic Value of Injury Severity and Lateralization of Lesion for Cognitive Deficits Following Severe Traumatic Brain Injury

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류심리과학

초록

본 연구의 목적은 뇌손상의 심각도와 뇌병변의 편재화가 인구학적 변인과 수상후 경과한 기간의 효과를 통제한 상태에서 심한 외상성 뇌손상 환자의 인지결함에 미치는 영향을 알아보는 것이었다. 대학병원 재활의학과 입원, 외래치료를 받았던 심한 폐쇄형 두부손상으로 진단된, 수상당시 나이 16~60세인 환자 92명을 대상으로 혼수기간, 뇌병변의 편재화, 수상후 경과기간, 나이, 교육수준에 대한 정보가 수집되었으며 신경심리 검사결과들이 후향적으로 수집되었다. 9가지 인지기능의 지표(언어성 지능지수, 동작성 지능지수, 전체지능 지수, 기억지수, 이름대기, 지각적 추론, 고차적 구성, 주의지속 요인, 처리속도)로 세분화한 분석에서 뇌손상의 심각도는 동작성 지능지수, 기억지수, 고차적 구성능력을 가장 잘 예측해 주었으며 언어성 지능지수, 이름대기, 주의지속 요인에는 영향을 미치지 않았다. 뇌병변의 편재화는 동작성 지능지수, 기억지수, 지각적 추론, 고차적 구성 능력에 의미있는 영향을 주었으며 좌/우/ 양반구 및 확산적 손상 환자군에 따른 특정 인지프로파일을 보였다. 본 연구에서는 특히 기억지수와 전두엽이 개입되는 고차적 구성능력은 인구학적 영향을 적게 받으면서 뇌손상의 심각도에 의한 설명력이 가장 많고 뇌병변의 편재화를 유의하게 변별해주는 인지기능들이었다. 본 연구결과는 외상성 뇌손상 환자를 평가하거나 개입전략을 세울 때 위험인자가 높은 환자들과 중점을 두어야 하는 인지기능들에 대한 정보를 제공해주고 있다.

Abstract

The purpose of this study was to explore the prognostic value of injury severity and lateralization of lesion for cognitive deficits following severe traumatic brain injury(TBI) while controlling for the effects of time postinjury and demographic variables. Patient demographics, injury severity, lateralization of lesion, time postinjury and neuropsychological test results were collected prospectively from 92 patients aged 16-60 years diagnosed with severe closed head injury. Nine cognitive functions(Verbal IQ(VIQ), Performance IQ(PIQ), Full Scale IQ(FSIQ), Memory Quotient(MQ), confrontational naming, complex construction, nonverbal eductive ability, freedom from distractibility and psychomotor speed) were analyzed. Injury severity had strong prognostic value for PIQ, MQ and complex construction but was not significantly related to VIQ, confrontational naming and freedom from distractibility. Lateralization of lesion had a significant impact on PIQ, MQ, nonverbal eductive ability and complex construction. There were implications of cognitive profiles specific to lateralization of lesion. The results suggest that especially memory and construction ability related to frontal lobe may be good indices of injury severity and lateralization of lesion. The findings of this study supply information about the important risk factors and dominant cognitive deficits of severe TBI that warrant attention from clinicians.

참고문헌 (73)

  1. 강순아, "외상성 뇌손상 환자군간 임상적 특징과 HABGT 반응 비교", 한국심리학회지 : 임상, 19(4), pp.819~829 (2000)
  2. 김귀애, "외상성 뇌손상 환자의 기억기능과 실행기능-뇌손상의 심각도에 따른 비교", 한국심리학회지 임상, 24(4), pp.849~867 (2005), 한국임상심리학회
  3. 김종상, "두부 손상 환자에서 정신증상과 뇌손상 부위와의 관계", 신경정신의학, 30(6), pp.996~1003 (1991)
  4. 김향희, "한국 보스톤 이름대기검사-전문가 지침서" (1997), 학지사
  5. 김홍근, "Rey-Kim 기억검사 해설서" (1999), 신경심리
  6. 노승호, "외상성 뇌손상 환자의 인지기능장애", 원광정신의학, 15(2), pp.15~26 (1999)
  7. 도진아, "외상성 뇌손상 환자들의 K-WAIS와 K-MAS 수행 패턴 비교", 생물치료정신의학, 11(2), pp.165~171 (2005), 대한생물치료정신의학회
  8. 박영숙, "심리평가의 실제" (1994), 하나의학사
  9. 박재설, "외상성 뇌손상 심도에 따른 인지장애와 시간경과 후 변화", 원광정신의학, 16(1), pp.3~11 (2000)
  10. 손희섭, "두부외상 환자에서 뇌손상 부위에 따른 우울증상 및 인지장애에 관한 연구", 신경정신의학, 33(4), pp.745~752 (1994)
  11. 염태호, "K-WAIS 실시요강" (1992), 한국 가이던스
  12. 오상우, "뇌손상 심도에 따른 외상성 뇌손상 환자의 지능 장애와 기억 장애 비교", 한국심리학회지 임상, 21(2), pp.340~360 (2002), 한국임상심리학회
  13. 오상우, "외상성 두뇌손상 환자의 지능장애와 기억장애", 한국심리학회지 : 임상, 19(2), pp.341~350 (2000)
  14. 오현수, "후급성기 뇌손상 환자를 위한 인지재활 프로그램의 개발", Journal of Korean Academy of Nursing, 35(2), pp.270~281 (2005), 한국간호과학회
  15. 이재광, "교통사고로 인한 두부외상 환자에서의 외상 후 기간과 정신과적 증상과의 관계", 신경정신의학, 35(1), pp.114~121 (1996)
  16. 이중용, "전두엽 및 측두엽 손상 환자의 인지와 정서장애", 신경정신의학, 29(5), pp.1059~1074 (1990)
  17. 장은영, "외상성 뇌손상 환자군간 K-WAIS와 Rey-Kim 기억검사 반응 비교", 한국심리학회지 임상, 22(1), pp.187~201 (2003), 한국임상심리학회
  18. 정근재, "단측 대뇌 손상에 의한 인지와 정서장애", 신경정신의학, 29(5), pp.1075~1097 (1990)
  19. 최성혜, "외손상 뇌 손상 환자의 기억기능 연구- 뇌 손상의 심각도에 따른 비교", 한국심리학회지 임상, 22(1), pp.33~56 (2003), 한국임상심리학회
  20. 최진영, "교통사고 환자에 대한 심리학적 평가", 임상심리학회 1995년도 제 2차 심포지움, pp.77~86 (1995)
  21. Al-Salamah, M. A., "Initial emergency department trauma scores from the OPALS study : the case for the motor score in blunt trauma", Academic Emergency Medicine, 11(8), pp.834~843 (2004)
  22. Banich, M. T., "Neuropsychology : the neural bases of mental function" (1997), Houghton Mifflin Company
  23. Banich, M. T., "Cognitive Neuroscience and Neuropsychology" (2004), Houghton Mifflin Company
  24. Ben-Yishay, Y., "Cognitive remediation in traumatic brain injury : update and issues", Archives of Physical Medicine & Rehabilitation, 74(2), pp.204~213 (1993)
  25. Brooks, N., "Return to work within the first seven years of severe head injury", Brain Injury, 1(1), pp.5~19 (1987)
  26. Carney, N., "Effect of cognitive rehabilitation on outcomes for person with traumatic brain injury : a systematic review", Journal of Head Trauma Rehabilitation, 14(3), pp.277~307 (1999)
  27. Cicerone, K. D., "Evidence-based cognitive rehabilitation : updated review of the literature from 1998 through 2002", Archives Physical Medicine & Rehabilita-tion, 86(8), pp.1681~1692 (2005)
  28. Ciurli P., "Neuropsychia-tric disorders in persons with severe traumatic brain injury : prevalence, phenomenology and relationship with demographic, clinical and functional features", Journal of Head Trauma Rehabilitation, 26(2), pp.116~126 (2011)
  29. Cremer, O. L., "Prognosis following severe head injury : development and validation of a model for prediction of death, disability, and functional recovery", Journal of Neurotrauma, 61(6), pp.1484~1491 (2006)
  30. Dikmen, S. S., "Outcome 3 to 5 years after moderate to severe traumatic brain injury", Archives Physical Medicine & Rehabilitation, 84(10), pp.1449~1457 (2003)
  31. Dikmen, S. S., "Cognitive outcome following traumatic brain injury", Journal of Head Trauma Rehabilitation, 24(6), pp.430~438 (2009)
  32. Draper K., "Psychosocial and emotional outcomes 10 years following traumatic brain injury", Journal of Head Trauma Rehabilitation, 22(5), pp.278~287 (2007)
  33. Fisher, D. C., "WAIS-Ⅲ and WMS-Ⅲ profiles of mildly to severity brain-injured patients", Applied Neuropsychology, 7(3), pp.126~132 (2000)
  34. Girard, D., "The relation-ship of neuropsychological status and productive outcomes following traumatic brain injury", Brain Injury, 10(9), pp.663~676 (1996)
  35. Glächer, J., "Lesion mapping of cognitive abilities linked to intelligence", Neuron, 61(5), pp.681~691 (2009)
  36. Golden, Z., "Impact of brain injury severity on personality dysfunction", International Journal of Neuroscience, 113(5), pp.733~746 (2003)
  37. Halldorsson J. G., "The prognostic value of injury severity, location of event, and age at injury in pediatric traumatic head injuries", Neuropsychiatric Disease and Treatment, 4(2), pp.405~412 (2008)
  38. Hammond F. M., "Changes and predictors of change in communication, cognition, and social fun-ction between 1 and 5 years after TBI", Journal of Head Trauma Rehabilitation, 19(4), pp.314~328 (2004)
  39. Haukoos, J. S., "Validation of the simplified motor score for the prediction of brain injury outcomes after trauma", Annals Emergency Medicine, 50(1), pp.18~24 (2007)
  40. Hesdorffer D. C., "Long-term psychiatric outcomes following traumatic brain injury : a review of the literature", Journal of Head Trauma Rehabilitation, 24(6), pp.452~459 (2009)
  41. Howard, M., "A manual of Behavior management strategies for traumatically brain-injured adults" (1983), Rehabilitation Institute of Chicago
  42. Jennette, B., "Assessment of outcome after severe brain damage", A practical scale the Lancet, 1, pp.480~484 (1975)
  43. Kampen, D. L., "Neuro- psychological evaluation of penetrating head injury, In Assess-ment of the behavioral consequences of head trauma" (1989), Alan R, Liss
  44. Kosch, Y., "Post-traumatic amnesia and it's relationship to the functional outcome of people with severe traumatic brain injury", Brain injury, 24(3), pp.479~485 (2010)
  45. Kurtzke, J. F., "Neuroepidemiology", Annals of Neurology, 16(3), pp.265~277 (1984)
  46. Lehtonen, S., "Neuropsychological outcome and community re-integration following traumatic brain injury : The impact ot frontal and non-frontal lesions", Brain injury, 19(4), pp.239~256 (2005)
  47. Lequerica, A. H., "Agitation in acquired brain injury : Impact on acute rehabilitation therapies", Journal of Head Trauma Rehabilitation, 22(3), pp.177~183 (2007)
  48. Lezak, M. D., "Neuropsychological assessment. 4th edition", pp.157~285 (2004), Oxford University Press
  49. Marquez de la Plata, C. D., "Impact of age on long-term recovery from traumatic brain injury", Archives of Physical Medicine & Rehabilitation, 89(5), pp.896~903 (2008)
  50. Matarazzo, J. D., "Clinical uses of the WAIS-R in Kaufman AS : assessing adolescent and adult intelligence" (1984), Allyn and Bacon, Inc
  51. Mosenthal, A. C., "The effect of age on functional outcome in mild traumatic brain injury : 6-month report of a prospective multi-center trial", Journal of Trauma, 56(5), pp.1042~1048 (2004)
  52. Murdoch, G. E., "Acquired speech and language disorders : a neuroanatomical and functional neurological approach" (1990), Chapman and Hall
  53. Nolin, P., "Relations among sociodemographic, neurologic, clinical, and neuropsychologic variables, and vocational status following mild traumatic brain injury : a follow-up study", Journal of Head Trauma Rehabilitation, 21(6), pp.514~526 (2006)
  54. Ponsford, J., "Factors influencing outcome following mild traumatic brain injury in adults", Journal of the International Neuropsychological Society, 6(5), pp.568~579 (2000)
  55. Prigatano, G. P., "Neuropsychological re-habilitation after brain injury" (1986), The Johns Hopkins Univ. Press
  56. Raven, J., "Manual for Raven's progressive matrices and vocabulary scales" (2003), OPP Limited
  57. Reeder, K. P., "Impact of age on functional outcome following traumatic brain injury", Journal of Head Trauma Rehabilitation, 11(3), pp.22~31 (1996)
  58. Rogers, J. M., "Psychia-tric comorbidity following traumatic brain injury", Brain Injury, 21, pp.1321~1333 (2007)
  59. Rosental, M., "Rehabilitation of the adult and child with traumatic brain injury" (1990), F. A. David company
  60. Rovlias, A., "Classification and regression tree for prediction of outcome after severe head injury using simple clinical and laboratory variables", Jourmal of Neurotrauma, 21(7), pp.886~893 (2004)
  61. Salmond, H., "Cognitive sequelae of head injury : invol-vement of basal forebrain and associated structures", Brain, 128(1), pp.189~200 (2005)
  62. Salmond, C. H., "Changes over time in cognitive and structural profiles of head injury survivors", Neuropsychologia, 44(10), pp.1995~1998 (2006)
  63. Satz, P., "Brain reserve capacity on symptom onset after brain injury : a formulation and review of evidence for threshold theory", Neuropsychologia, 7(3), pp.273~295 (1993)
  64. Scheibel, R. S., "Effects of severity of traumatic brain injury and brain reserve on cognitive-control related brain activation", Journal of Neurotrauma, 26(9), pp.1447~1461 (2009)
  65. Shordone, R. J., "Mild traumatic brain injury does not produce post-traumatic stress disorder", Brain Injury, 9(4), pp.45~52 (1995)
  66. Sohlberg, M. M., "Introduction to cognitive rehabilitation and practice", pp.3~17 (1989), The Guildford Press
  67. Solé-Padullés, C., "Brain structure and function related to cognitive reserve variables in normal aging, mild cognitive impairment and Alzheimer's diseases", Neurobiology of Aging, 30(7), pp.1114~1124 (2009)
  68. Thomsen, I. V., "Late outcome of very severe blunt head trauma : a 10-15 year second follow-up. Journal of Neurology", Neurosurgery and Psychiatry, 47(3), pp.260~268 (1984)
  69. Whelan-Goodinson, R., "Predictors of psychiatric disorders following traumatic brain injury", Journal of Head Trauma Rehabilitation, 25(5), pp.320~329 (2010)
  70. Wilson, B., "Predicting severity of cognitive impair-ment after severe head injury", Brain Injury, 5(2), pp.189~197 (1991)
  71. Wolters, G., "Coping following acquired brain injury : predictors and correlates", Journal of Head Trauma Rehabilitation, 26(2), pp.150~157 (2011)
  72. Wood, R. L., "Demographic and cognitive predictors of long-term psychosocial outcome following traumatic brain injury", Journal of International Neuropsychological Society, 12(3), pp.350~358 (2006)
  73. Zillmer, E. A., "Principles of neuropsychology", pp.2001, Wadsworth

관련 논문AI추천

이 간행물의 다른 논문 (19건)