중의학 데이터베이스인 TCMID와 TCMSP로부터 '동의수세보원 신축본'에 제시된 사상체질별 본초 선별 연구
The study on the selection of Sasang Constitution-specific herbs in 『Dongyisusebowon Sinchuk-Bon』 from TCMID and TCMSP
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Objectives The network pharmacological study on herbal remedies in Traditional Chinese Medicine (TCM) is actively being carried out based on the TCM databases such as TCMID and TCMSP. It is necessary to select Sasang Constitution-specific (SC-s) herbs from these databases in order to study the prescriptions in Sasang Constitutional Medicine. Methods SC-s herbs and their processing types listed in 『Dongyisusebowon Sinchukbon』 were searched from TCMID and TCMSP. Results and Conclusions 1. There were total 144 herbs (Soeum 47, Soyang 37, Taeeum 44, Taeyang 16 specific herbs) listed in 『Dongyisusebowon Sinchukbon』. 2. There were total 130 herbs (Soeum 43, Soyang 37, Taeeum 42, Taeyang 8 specific herbs) searched from TCMID, and total 92 herbs (Soeum 31, Soyang 30, Taeeum 27, Taeyang 4 specific herbs) from TCMID. 3. In some cases, the name given in 『Dongyisusebowon Sinchukbon』 was different from that in TCMID and TCMSP. It was needed to be careful during the searching process. 4. Although the processing form of some herbs could be searched, there was a significant reduction in the herbal compound information compared to the raw form. It is necessary to reconsider whether or not to use the processing form. 5. Herbal scientific names given in TCMID and TCMSP or used in China and Korea were different each other in some cases. Additional screening process among such herbs would be required based on the efficacy of herbs used in clinical field.
Abstract
Objectives The network pharmacological study on herbal remedies in Traditional Chinese Medicine (TCM) is actively being carried out based on the TCM databases such as TCMID and TCMSP. It is necessary to select Sasang Constitution-specific (SC-s) herbs from these databases in order to study the prescriptions in Sasang Constitutional Medicine. Methods SC-s herbs and their processing types listed in 『Dongyisusebowon Sinchukbon』 were searched from TCMID and TCMSP. Results and Conclusions 1. There were total 144 herbs (Soeum 47, Soyang 37, Taeeum 44, Taeyang 16 specific herbs) listed in 『Dongyisusebowon Sinchukbon』. 2. There were total 130 herbs (Soeum 43, Soyang 37, Taeeum 42, Taeyang 8 specific herbs) searched from TCMID, and total 92 herbs (Soeum 31, Soyang 30, Taeeum 27, Taeyang 4 specific herbs) from TCMID. 3. In some cases, the name given in 『Dongyisusebowon Sinchukbon』 was different from that in TCMID and TCMSP. It was needed to be careful during the searching process. 4. Although the processing form of some herbs could be searched, there was a significant reduction in the herbal compound information compared to the raw form. It is necessary to reconsider whether or not to use the processing form. 5. Herbal scientific names given in TCMID and TCMSP or used in China and Korea were different each other in some cases. Additional screening process among such herbs would be required based on the efficacy of herbs used in clinical field.
참고문헌 (23)
- Boezio B, "Network-based Approaches in Pharmacology", Mol Inform, 36(10) (2017)[DOI]
- Zhang W, "Systems Pharmacology for Investigation of the Mechanisms of Action of Traditional Chinese Medicine in Drug Discovery", Front Pharmacol, 10, pp.743~ (2019)
- 이수진, "Systems Biology - A Pivotal Research Methodology for Understanding the Mechanisms of Traditional Medicine", Journal of Pharmacopuncture, 18(3), pp.11~18 (2015), 대한약침학회[DOI]
- Xue R, "TCMID: Traditional Chinese Medicine integrative database for herb molecular mechanism analysis", Nucleic Acids Res, 41, pp.D1089~D1095 (2013)[DOI]
- Huang L, "TCMID 2.0: a comprehensive resource for TCM", Nucleic Acids Res, 46(D1), pp.D1117~D1120 (2018)[DOI]
- Ru J, "TCMSP: a database of systems pharmacology for drug discovery from herbal medicines", J Cheminform, 6, pp.13~ (2014)[DOI]
- 임수혜, "Pharmacognostic outlooks on medical herbs of Sasang typology", Integrative Medicine Research, 6(3), pp.231~239 (2017), 한국한의학연구원[DOI]
- 황상문, "중국 네트워크약리학 데이터베이스 구축 현황 및 TCMSP의 활용가능성 검토 - 사상체질의학의 약물을 중심으로 -", 동의생리병리학회지, 29(6), pp.443~450 (2015), 한의병리학회[DOI]
- Bae HS, "The study on the formative process of Soeumin prescription", J. of Sasang Const. Med, 14(1), pp.10~25 (2002)
- Bae HS, "The study on the formative process of Soyangin prescription", J. of Sasang Const. Med, 14(3), pp.33~51 (2002)
- Bae HS, "The study on history of prescription through comparison Dongyi-Soose-Bowon Chopanbon with Sasang-Yihak-Chobonguen and Dongyi-Soose-Bowo", J. of Sasang Const. Med, 13(2), pp.110~123 (2001)
- Kim JY, "A Research on the Classification of Herbal Medicines based on the Sasang Constitution (Taeumin and Taeyangin Part)", J. of Sasang Const. Med, 14(1), pp.1~9 (2002)
- 한상용, "방제 연구를 위한 새로운 접근: 네트워크 약리학", 동의생리병리학회지, 30(6), pp.385~396 (2016), 한의병리학회[DOI]
- 김인락, "藿香의 기원식물에 대한 문헌적 연구", 대한본초학회지, 21(4), pp.43~49 (2006), 대한본초학회
- 강태곤, "少陽人 처방 중 赤白茯？ 구별의 필요성 與否 고찰", 사상체질의학회지, 19(1), pp.38~49 (2007), 사상체질의학회
- 김인락, "傷寒論에서 梔子의 基原과 1일 복용량", 대한본초학회지, 26(4), pp.155~161 (2011), 대한본초학회
- Kim NJ, "Studies on the processing of Crude drugs(V)- On the constituents and biological activities of Glycyrrhize Ridix by processing", Ko. J. Pharmacogn, 27(3), pp.196~206 (1996)
- 김인락, "傷寒論에서 炮附子와 生附子의 1 일 복용량", 대한본초학회지, 30(4), pp.51~55 (2015), 대한본초학회
- 방경환, "RAPD마커를 이용한 황기의 유전적 다양성 및 기원판별", 동의생리병리학회지, 18(3), pp.825~829 (2004), 한의병리학회
- Lee CS, "Bibliographical study on the source of morphology of Amomum", Kor. J. Herbol, 1(1), pp.96~105 (1986)
- 이영미, "오미자 (五味子) 종 감별을 위한 RAPD 유래 SCAR Marker 및 Multiplex-PCR 기법 개발", 한국약용작물학회지, 21(3), pp.165~173 (2013), 한국약용작물학회[DOI]
- Choi H, "Studies of name and herbal origins of Ha-Soo-Oh", Korean J. Oriental Med, 9(1), pp.81~89 (2003)
- Park HK, "A study on the Qualitative and Quantitative Analysis of Essential oil in Angelicae tenuissimae Radix or Ligustici rhizoma", Korean J. Food Sci. Technol, 29(2), pp.189~193 (1997)