네트워크 약리학을 활용한 보명지주 본초와 면역기능 간의 연관성 탐색 연구
A Study on Exploring the Relationship Between Bo-Myeong-Ji-Ju Herbs and Immune Function Using Network Pharmacology
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Objectives This study explores the immunological effects of Sasang constitutional medicine (SCM) by analyzing the interaction between Bomyeongjiju herbs and immune-related processes through network pharmacology. Methods Bomyeongjiju herbs for each Sasang type were identified from Dongmuyoogo and selected formulas, focusing on 23 herbs. Compound and target data were obtained from OASIS and related databases, creating a network of 420 targets and 1,000 interactions. Enrichment analysis was conducted using 122 immune-related Gene Ontology terms to identify significant associations by Sasang type. Results Network analysis found that Bomyeongjiju herbs were associated with immune functions at rates significantly above chance, with an average of 18.56 immune terms per herb. So-eum’s herbs were linked to microglial and macrophage activation, So-yang’s to MyD88-dependent Toll-like receptor signaling, Tae-eum’s to leukocyte migration, and Tae-yang’s to T-helper 17 Cell Differentiation. Conclusions Bomyeongjiju herbs demonstrate constitution-specific immunomodulatory potential, supporting SCM’s personalized approach. The findings indicate that SCM can influence distinct immune functions by constitution, which may help address immune-related diseases effectively.
Abstract
Objectives This study explores the immunological effects of Sasang constitutional medicine (SCM) by analyzing the interaction between Bomyeongjiju herbs and immune-related processes through network pharmacology. Methods Bomyeongjiju herbs for each Sasang type were identified from Dongmuyoogo and selected formulas, focusing on 23 herbs. Compound and target data were obtained from OASIS and related databases, creating a network of 420 targets and 1,000 interactions. Enrichment analysis was conducted using 122 immune-related Gene Ontology terms to identify significant associations by Sasang type. Results Network analysis found that Bomyeongjiju herbs were associated with immune functions at rates significantly above chance, with an average of 18.56 immune terms per herb. So-eum’s herbs were linked to microglial and macrophage activation, So-yang’s to MyD88-dependent Toll-like receptor signaling, Tae-eum’s to leukocyte migration, and Tae-yang’s to T-helper 17 Cell Differentiation. Conclusions Bomyeongjiju herbs demonstrate constitution-specific immunomodulatory potential, supporting SCM’s personalized approach. The findings indicate that SCM can influence distinct immune functions by constitution, which may help address immune-related diseases effectively.
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