골모세포주，상아모세포주 및 백악모세포주에서OD314의 분포에 관한 면역세포화학적 연구

Abstract

There were lots of works to identify the cellular factors (specific gene or master gene) and their functions related with tooth development and differentiation, However the mechanism and function for the controls of each factors in cellular environment were still unclear. Recently OD314 has been identified as an odontoblast specific gene that might be have a function such as regeneration and differentiation. In previous report we have described that OD314 may 미ay a important role in mineralization process of dentinogenesis and also regulate odontoblast• related genes such as OC, ON, and DSPP. We need some broad S야culation for this function to draw out exact cellular functions Therefore, using various cell lines related with fibroblast, odontoblast, cementoblast, and preosteoblast (NIH3T3, MDPC23, ODll , OCCM30, MC3T3-Ell we have conducted immunofluoresence microscopical analysis using OD314 antibody From the results we suggest that 0D314 is a potential factor as described below hyp야hesis. 1) Outgrowth and differentiation related protein? 2) Migration related protein? 3) Trafficking related protein? 4) Forcal contact related protein? 5) Nucleus membrane protein?