아토피피부염의 손상된 피부장벽에 대한 혼합오일의 회복 효과
Recovery Effect of Blending Oil on Skin Barrier Damaged by Atopic Dermatitis
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초록
목적: 본 연구는 배초향, 로즈마리, 라벤더 오일을 혼합한 ARL oil이 아토피피부염을 유발시킨 생쥐의 피부장벽의 회복에 미치는 효과를 검증하는 것이다. 방법: 6주령 된 생쥐 24마리를 각각 8마리씩 대조군, 아토피피부염 유발군, ARL oil 처리군으로 배치하였고, 대조군을 제외한 두 군에 아토피피부염을 유발시켰다. ARL oil 처리군에 6일간 하루 2회씩 ARL oil을 처리해주었다. 아토피피부염 유발쥐의 표피두께, 콜라겐의 양적 변화, TGF-β의 발현정도를 측정하였다. 결과: ART oil 처리군에서 표피두께, 콜라겐의 양, TGF-β의 발현 정도가 아토피피부유발군에 비해 유의하게 감소하였다. 결론: ARL oil은 아토피피부염에 대한 간호중재방법으로서의 가능성이 있다.
Abstract
Purpose: The purpose of this study was to evaluate the effect of a mixture of ARL oils, Agastache rugosa, Rosemarinu officinalis, and Lavandula angustifolia on atopic dermatitis (AD) model on NC/Nga mice. Methods: Twenty-four, 6 week-NC/Nga mice were assigned to a control group (C, n=8), an AD-induced group (E, n=8), and an ARL oil-treated group (E, n=8) that had two treatments per day for 6 days. Epidermis thickness, total amount of collagen and expression of TGF-β in the AD induced mice were measured. Results: The ARL oil-treated group showed a significantly decreased epidermis thickness, and a greater amount of collagen and expression of TGF-β compared with the AD-induced group. Conclusison: ARL oil may be a putative resources for care or treatment of AD in the view of nursing intervention.
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