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Anti-wrinkle Effects of Black Snow, Sun, and Red Ginseng Water Extracts on Human Dermal Fibroblasts

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초록

A variety of commercially processed ginseng products, including black snow ginseng (BSG), sun ginseng (SG), and red ginseng (RG) are currently available in the market. To evaluate the anti-wrinkle effects of Panax ginseng (BSG, SG, and RG) water extracts (PGWEs: BSGWE, SGWE, and RGWE), collagen synthesis and degradation abilities of PGWEs were assessed using human dermal fibroblasts. BSGWE, SGWE, and RGWE at the concentration of 50 μg/mL increased type-I procollagen synthesis by 82.7% (p<0.001), 26.9% (p<0.01), and 119.2% (p<0.001), respectively, in comparison to control cells. In comparison to control cells, treatments with 50 μg/mL of BSGWE, SGWE, and RGWE significantly (p<0.001) decreased the activity of matrix metalloproteinase-2 (MMP-2) and the mRNA and protein expression of MMP-1. PGWEs were found to promote collagen synthesis and inhibit its degradation in human dermal fibroblasts. Among PGWEs, RGWE showed the most effective anti-wrinkle effects.

Abstract

A variety of commercially processed ginseng products, including black snow ginseng (BSG), sun ginseng (SG), and red ginseng (RG) are currently available in the market. To evaluate the anti-wrinkle effects of Panax ginseng (BSG, SG, and RG) water extracts (PGWEs: BSGWE, SGWE, and RGWE), collagen synthesis and degradation abilities of PGWEs were assessed using human dermal fibroblasts. BSGWE, SGWE, and RGWE at the concentration of 50 μg/mL increased type-I procollagen synthesis by 82.7% (p<0.001), 26.9% (p<0.01), and 119.2% (p<0.001), respectively, in comparison to control cells. In comparison to control cells, treatments with 50 μg/mL of BSGWE, SGWE, and RGWE significantly (p<0.001) decreased the activity of matrix metalloproteinase-2 (MMP-2) and the mRNA and protein expression of MMP-1. PGWEs were found to promote collagen synthesis and inhibit its degradation in human dermal fibroblasts. Among PGWEs, RGWE showed the most effective anti-wrinkle effects.

참고문헌 (32)

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