Helicobacter pylori 위염에서의 비만세포와 염증반응과의 관련성

Abstract

Helicobacter pylori(H. pylori) induces severe inflammation and plays a key role in gastric mucosal disease. In general, mast cells are well known as initiators and regulators of inflammation, but their role in the gastric mucosal inflammation caused by H. pylori still remains unclear. Therefore， this study was performed to investigate the differences of number of mast cell and mast cell degranulation in gastritis with and without H. pylori infection. Endoscopic biopsy specimens from 21 H. pylori-positive and 19 H. pylori-negative subjects were examined. The sections were cut from routinely formalin-fixed and paraffin embedded tissues, and stained with hematoxylin-eosin(HE), Warthin-Starry(WS) and 0.5% toluidine blue(TB) respectively. HE-and WS-stained sections were assessed for inflammation and infection, and TB-stained sections were used in mast cell counting. The mast cells were quantificated the numbers per square millimeter using a computerized image analysis system. Mean number of mast cell and degranulated mast cell were significantly higher in the mucosa with H. pylori infection than in the mucosa of noninfected gastritis subjects. These also correlated significantly with the inflammatory intensity Thus, mast cells may be important effector cells in the pathogenesis of H. pylori infected gastritis.