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조직학적 위험 분류에 따른 위장관 간질종양에서 C-kit, DOG1, CD34, PKC-θ, PDGFR 발현의 비교

Comparisons of C-kit, DOG1, CD34, PKC-θ and PDGFR-α Expressions in Gastrointestinal Stromal Tumors According to Histopathological Risk Classification

송혜정|신원섭|김기성|송강원
대한임상검사과학회 (Korean Society for Clinical Laboratory Science)|2011.06|대한임상검사과학회지 (Korean Journal of Clinical Laboratory Science)|제43권 제2호|pp. 48-56

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Abstract

Gastrointestinal stromal tumor (GIST) is a mesenchymal tumor and is associated with a specific immunophenotype index. It is very important to identify the specific immunophenotype and the diagnosis for the treatment GIST patients. Ninety two cases of GIST analyzed in this study were immuno-stained for c-kit, DOG1, CD34, PKC-θ, PDGFR-α. The rate of positive staining and statistical significance were then compared. In addition, the GISTs were analyzed as followings: very low risk, low risk, intermediate risk and high risk according to tumor size and nuclear division, and later correlated with clinical parameters. The results of the GIST positive stainings were: DOG1 (95.7%), PKC-θ (90.2%), PDGFR-α (88.0%), c-kit (87.0%) and CD34 (71.7%). Only DOG1 staining showed a statistical significance of p<0.05. It was identified in the classification system of histologic risk that staining expression of DOG1, PKC-θ, PDGFR-α were significantly increased as histologic risk increases (p<0.05). However, clinical parameters such as age and sex of patients have no correlations with the classification system of histologic risk (p>0.05). Therefore, in this study, the expression of DOG1 showed statistical significance and DOG1, PKC-θ, PDGFR-α staining increased significantly as the histologic risk increases in histologic classification system. Taken together, the DOG1 staining should be very effective for the diagnosis of GIST patients.

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c-kit, PDGFRA의 면역조직화학적 발현 양상과 변이 분석을 통한 위장관기질종양 진단의 접근강병욱, 김재훈, 김정식, 김종광, 배한익, 서인수, 오현진, 유완식, 정호영대한병리학회 · Journal of Pathology and Translational Medicine2010 · 제44권 제2호위장관 간질종양에서 c-kit유전자 돌연변이 및 면역조직화학적 발현강대영, 강동욱, 김경희, 김동훈, 김주헌, 박미자대한병리학회 · Journal of Pathology and Translational Medicine2003 · 제37권 제4호Clinicopathological and Immunohistochemical Features of Gastointestinal Stromal Tumors강유나, 정혜라, 황일선대한암학회 · Cancer Research and Treatment2010 · 제42권 제3호위장관기질종양에서 DOG1 발현의 진단적 유용성김애리, 김준모, 배영경, 최준혁대한병리학회 · Journal of Pathology and Translational Medicine2010 · 제44권 제2호Expression of DOG1, PDGFRA, and p16 in Gastrointestinal Stromal Tumors강동욱, 서광선, 정성희, Dae Young Kang, Eun Sun Kim, Young-Beum Kim거트앤리버 소화기연관학회협의회 · Gut and Liver2011 · 제5권 제2호Clinical Practice Guideline for Accurate Diagnosis and Effective Treatment of Gastrointestinal Stromal Tumor in Korea강윤구, 강혜진, 김경미, 김우호, 류민희, 손태성, 양한광, 최동일대한암학회 · Cancer Research and Treatment2012 · 제44권 제2호

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