당뇨병 지표와 만성 B 형 간염 바이러스 감염의 상관 관계
Correlation of Chronic Hepatitis B Virus Infection with Diabetes Mellitus Indicators
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Hepatitis B virus (HBV) infection has recently shown to be associated with diabetes mellitus. The objective of this study was to investigate the relationship between chronic hepatitis B and diabetes mellitus indicators. We evaluated anthropometry, metabolic syndrome risk factors, fasting glucose, HbA1c, and C-peptide among the normal and HBV subjects. The partial correlation and average comparison analysis were used to assess the independent association between chronic hepatitis B and diabetes mellitus indicators. Average comparisons of normal and HBV subjects were significantly different in fasting glucose (p＜0.000), HbA1c (p＜0.000), C-peptide (p＜0.000), alanine transaminase (ALT) (p＜0.000) and aspartate transaminase (AST) (p＜0.000). We may suggest that HBV infection is related to diabetes mellitus indicators such as fasting glucose, HbA1c and C-peptide.
Abstract
Hepatitis B virus (HBV) infection has recently shown to be associated with diabetes mellitus. The objective of this study was to investigate the relationship between chronic hepatitis B and diabetes mellitus indicators. We evaluated anthropometry, metabolic syndrome risk factors, fasting glucose, HbA1c, and C-peptide among the normal and HBV subjects. The partial correlation and average comparison analysis were used to assess the independent association between chronic hepatitis B and diabetes mellitus indicators. Average comparisons of normal and HBV subjects were significantly different in fasting glucose (p＜0.000), HbA1c (p＜0.000), C-peptide (p＜0.000), alanine transaminase (ALT) (p＜0.000) and aspartate transaminase (AST) (p＜0.000). We may suggest that HBV infection is related to diabetes mellitus indicators such as fasting glucose, HbA1c and C-peptide.
참고문헌 (25)
- Albarrak AI, "Associations of glucose control with insulin sensitivity and pancreatic beta-cell responsiveness in newly presenting type 2 diabetes", J Clin Endocrinol Metab, 87, pp.198~203 (2002)
- Arbuthnot P, "Putative role of hepatitis B virus X protein in hepatocarinogenesis: effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK", STAT pathways, 2000, pp.15, 357~368
- Beasley RP, "The e antigen and vertical transmission of hepatitis B surface antigen", Am J Epidemiol, 105, pp.94~98 (1977)
- Bonora E, "Possible roles of insulin, glucagon, growth hormone and free fatty acids in the pathogenesis of insulin resistance of subjects with chronic liver diseases", Acta Diabetol Lat, 21, pp.241~250 (1984)
- Bouchard MJ, "The enigmatic X gene of Hepatitis B virus", J Virol, 78, pp.12725~12734 (2004)
- Bratusch-Marrain PR, "The effect of growth hormone oin glucose metabolism and insulin secretion in man", J Clin Endocrinol Metab, 55, pp.973~982 (1982)
- Chisari FV, "Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice", Cell, 59, pp.1145~1156 (1989)
- 최필병, "장기간의 규칙적인 운동과 약물요법이 제2형 당뇨병 환자의 당뇨지표, 혈중지질 및 골밀도에 미치는 영향", 한국체육학회지, 50(3), pp.513~522 (2011), 한국체육학회
- Dejean A, "Detection of hepatitis B virus DNA in pancreas, kidney and skin of two human carriers of the virus", J Gen Virol, 65(3), pp.651~655 (1984)
- Del Prato S, "Hyperglucagoneemia and insulin mediated glucose metabolism", J Clin Invest, 79, pp.547~556 (1987)
- Diao J, "X protein of Hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarinogenesis", Cytokine Growth Factor Rev, 12, pp.189~205 (2001)
- Feitelson MA, "Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma", Am J Pathol, 150, pp.1141~1157 (1997)
- Ferrannini E, "Effect of fatty acids on glucose production and utilization in man", J Clin Invest 7, 72, pp.1737~1747 (1983)
- Han KH, "The perspective of new antiviral agents for hepatitis B virus", Korean J Hepatol, 9(Suppl 2), pp.20~26 (2003)
- Hoefs JC, "Hepatitis B surface antigen in pancreatic and biliary secretions", Gastrienterology, 79, pp.191~194 (1980)
- Huh KB, "Atypical diabetes in Koreans", Korean J Int Med, 33, pp.762~770 (1987)
- Kim JR, "Mechanism of glucose intolerance in chronic liver disease-role of glucagon and free fatty acid", Diabetes Metab J, 10, pp.173~179 (1986)
- Kim KH, "Pro-apoptotic function of hepatitis B virus X protein", Korean J Hepato, 16, pp.112~122 (2010)
- Kingston ME, "Diabetes mellitus in chronic active hepatitis and cirrhosis", Ggastroenterology, 87, pp.688~694 (1984)
- Lee WM, "Hepatitis B virus infection", N Engl J Med, 337, pp.1733~1745 (1997)
- Park SH, "Insulin resistance in not associated with histologic severity in nondiabetic, noncirrhotic patients with chronic hepatitis B virus infection", Am J Gastroenterol, 104, pp.1135~1139 (2009)
- Polonsky K, "Metabolism of C-peptide in the dog. In vivo demonstration of the absence of hepatic extraction", J Clin Invest, 72, pp.1114~1123 (1983)
- Polonsky KS, "Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type Ⅰ diabetes patients", J Clin Invest, 77, pp.98~105 (1986)
- Polonsky KS, "C-peptide and insulin secretion. Relationship between peripheral concentrations of C-peptide and insulin and their secretion rates in the dog", J Clin Invest, 74, pp.1821~1829 (1984)
- Polonsky KS, "Current approaches to measurement of insulin secretion", Diabetes, 1986, pp.2, 315~329