흰쥐 피부의 창상 치유에 관한 광학현며경 및 전자현미경적 관찰

Abstract

The purpose of this study is to investigate the Process of the wound healing and the morphologic mechanism of the scar formation. We made primary and secondary wounds in the back of Sprague-Dawley rats. The Wounds were harvesed at first day, third day, fifth day, seventh day, fourteenth day and twenty eighth day. The specimens were taken form primary and secondary wound sites and processed for light microscopy and electron microsopy. Generally, secondary wounds showed more prominant contractionand longer tome required for complete healing than primary wounds. Light microscopically inflammatory reaction was more predominant and the granulation tissue was more abundant in the secondary wounds. Ultrastructurally, neutrophils began to appear at the first day after wound in both primary and secondary wounds. Myofibroblasts appered at fourteenth day in the cases of the primary and secondary woumds. Collagen bundles were observed on third day and more increased and thick in the secondary wound at second and fourth weeks. From this study, secondary wound showed more severe inflamatory reation, wound contraction and collagen deposition than primary wound. We believe thath primary wound process is necessary to prevent the complication and to minimize the scar tissue for successful wound healing.