대전지역 일개 종합병원에서의 비예기 항체 발생현황과 분포
Frequencies and Distributions of Unexpected Antibodies at a General Hospital in the Daejeon of Korea
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초록
수혈 준비 시 비예기 항체 선별검사를 통한 항체의 유무와 그 종류를 아는 것은 매우 중요하다. DiaMed-ID시스템을 이용하여 대전지역 일개 대학병원에 2016년 1월부터 2017년 12월까지 2년 동안 의뢰된 비예기 항체 선별검사 양성자 중에서 항체동정은 55명에서만 되었고 주로 여성에서 자주 동정되었다. Rh 36예(65.5%), Lewis 7예(12.7%), Kidd 4예(7.3%), Duffy 4예(7.3%), MNSs 3예(5.5%), Rh+Kidd 복합 1예(1.8%)가 동정되었는데, Rh 계열은 Anti-E 19예(34.5%), Anti-E/-c 4예(7.3%), Anti-C/-e 4예(7.3%), Anti-E/-c/-Jkb 1예(1.8%)가, Lewis 계열은 Anti-Lea 3예(5.5%), Anti-Leb 3예(5.5%), Kidd 계열은 Anti-Jka 1예(1.8%), Anti-Jkb 3예(5.5%)가 동정되었다. Duffy와 MNSs 계열은 각각 Anti-Fya 1예(1.8%), Anti-Fyb 3예(5.5%), Anti-M 2예(3.6%), Anti-S 1예(1.8%)가 동정되었다. 최근 대전의 비예기 항체 빈도와 분포가 반영된 이 연구는 효율적인 수혈준비에 도움이 될 것이다.
Abstract
When preparing for a blood transfusion, the presence and types of unexpected antibodies should be identified through screening tests. Using the DiaMed-ID system, antibody identification among unexpected antibody screening tests performed at a university hospital in Daejeon area for two years from January 2016 to December 2017 were limited to 55 patients and were predominantly women. A total of 36 patients (65.5%) belonged to the Rh group, 7 (12.7%) patients to the Lewis group, 4 (7.3%) patients to the Kidd and Duffy groups, 3 patients (5.5%) to the MNS group, and 1 (1.8%) to the Rh+Kidd combined group. In the Rh group, 19 (34.5%) patients had Anti-E single antibody, 5 (9.1%) patients had Anti-D single antibody, 4 (7.3%) patients had Anti-E/-c, 4 (7.3%) patients had Anti-C/-e, and 1 (1.8%) patient had Anti-E/-c/-Jkb. In the Lewis group, three (5.5%) patients had both Anti-Lea and Anti-Leb. In the Kidd group, one (1.8%) patient had Anti-Jka and three (5.5%) patients had Anti-Jkb. In the Duffy and MNS groups, only single antibody was found: one (1.8%) patient with Anti-Fya, three (5.5%) patients with Anti-Fyb, two (3.6%) patients with Anti-M, and one (1.8%) patient with Anti-S. This study reflects the recent frequencies and distributions of unexpected antibodies in Daejeon, which would be helpful for the efficient preparation for transfusions.
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