대한민국에서 비만에 대한 고감도 C-반응성 단백과 요산의 상호작용: 제7기 국민건강영양조사를 이용해서(KNHANES VII, 2016∼2018)
The Interaction of High Sensitivity C-Reactive Protein and Uric Acid on Obesity in Koreans: Based on the Seventh Korea National Health and Nutrition Examination Survey (KNHANES VII, 2016∼2018)
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초록
제7기 국민건강영양조사 자료(2016∼2018)를 이용해서 고감도 C반응성 단백(hsCRP)과 요산의 비만에 대한 위험도와 상호 작용이 있는지 알아보고자 하였다. 비만은 체질량지수(BMI)가 25 kg/m2 이상으로, 중증 비만은 BMI가 30 kg/m2 이상으로, 병적비만은 BMI가 35 kg/m2 이상으로 정의하였다. 복합표본 다중 로지스틱 회귀분석에서 주요한 위험인자를 추가하여 보정하였음에도 불구하고 고농도의 hsCRP와 고농도의 요산이 동시에 존재하는그룹은 기준 그룹보다 비만의 오즈비(odds ratio, OR)가 모든 단계에서 높았다(비만, OR 1.89, P＜0.001 vs. 심한 비만, OR 5.04, P＜0.001 vs. 병적인 비만, OR 8.20, P＜0.001). 비만의 단계가높아질수록 비만에 대한 hsCRP와 요산의 오즈비가 1.89에서8.20으로 높아졌다, 이는 BMI가 증가된 참가자일수록 hsCRP와요산의 관련성이 크다는 것을 암시한다. 더욱이, 복합표본 일반선형분석에서 주요한 교란 요인을 보정한 후 비만에 대한 hsCRP와요산 사이의 상호 작용이 분석되었다(P for interaction=0.009).
Abstract
We used data from the 7th Korea National Health and Nutrition Examination Survey (KNHANES) (2016∼2018) to investigate an association between high sensitivity C-reactive protein (hsCRP) and uric acid in the obese. Obesity was defined as a body mass index (BMI) of 25 kg/m2 or more, severe obesity as a BMI of 30 kg/m2 or more, and morbid obesity as a BMI of 35 kg/m2 or more. In the complex samples multiple logistic regression, despite adjustment by adding major risk factors, the odds ratio (OR) for obesity was higher in the group with high levels of both, hsCRP and uric acid than the reference group at all stages (obesity, OR 1.89, P＜0.001 vs. severe obesity, OR 5.04, P＜0.001 vs. morbid obesity, OR 8.20, P＜0.001). The association between hsCRP and uric acid in obese patients increased from 1.89 to 8.20 as the obesity level increased, suggesting that participants with increased BMI were significantly affected by hsCRP and uric acid. Moreover, the interaction between hsCRP and uric acid was statistically significant even in the model corrected for major confounding factors (P for interaction=0.009).
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