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분열형 인격성향과 강박성향을 가진 여자대학생의 신경심리 프로파일 비교

Neuropsychological Profiles of Female College Students with Schizotypal and Obsessive-Compulsive Traits

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초록

본 연구는 분열형 인격성향군과 강박성향군의 신경심리 기능을 비교하여 두 성향군이 공통된 인지 결함을 가지고 있는가를 조사하였으며 이를 통하여 정신분열병의 하위 유형으로 제안되고 있는 정신분열-강박장애(schizo-obsessive subtype of schizophrenia)가 아임상 수준에서 존재하는가를 알아보고자 하였다. 분열형 성격질문지와 강박척도 점수에 근거하여 분열형 인격성향군(n=18), 강박성향군(n=19)과 정상통제군(n=22)을 선정하였다. 신경심리 기능의 평가에는 주의(Trail Making Test: TMT, d2 test, Stroop test), 집행기능(Wisconsin Card Sorting Test: WCST)과 기억(Korean version of the California Verbal Learning Test: K-CVLT, Rey-Osterrieth Complex Figure Test: RCFT)이 포함되었다. 분열형 인격성향군이 강박성향군과 정상통제군에 비하여 Stroop 검사의 단어읽기 과제, d2 검사의 주의집중력지표와 K-CVLT의 1-5차 회상수에서 유의하게 낮은 수행을 보였다. 또한 분열형 인격성향군과 강박성향군 모두 정상통제군에 비하여 WCST에서 유의하게 더 많은 총오반응수, 보속반응수와 보속 오반응수를 보였다. 이에 덧붙여서 분열형 인격성향군과 강박성향군은 정상통제군에 비하여 각각 강박척도와 분열형 성격질문지에서 유의하게 더 높은 점수를 보였다. 신경심리검사 및 행동 척도의 결과는 비록 분열형 인격성향군이 강박성향군에 비하여 더 다양한 인지 영역에서 결함을 가지고 있지만 두 성향군이 전전두엽에 의해 통제되는 집행기능의 결함과 정신분열병과 강박장애에서 관찰되는 일부 행동 특징을 공유하고 있음을 시사한다. 또한 이 결과는 정신분열병의 한 하위 유형으로 제안되고 있는 정신분열-강박장애가 아임상 수준에서 이미 존재하고 있음을 시사한다.

Abstract

This study investigated the neuropsychological functioning of female college students with schizotypal and obsessive-compulsive traits. Based on scores from the Schizotypal Personality Questionnaire(SPQ), Maudsley Obsessive-Compulsive Inventory(MOCI), and the Padua Inventory(PI), schizotypal-trait(n=18), obsessive -compulsive trait(n=19) and normal control(n=22) groups were selected. For the measurement of neuropsychological functions, attention(Trail Making Test: TMT, d2, Stroop test), memory(Korean version of California Verbal Learning Test: K-CVLT, Rey-Osterrieth Complex Figure Test: RCFT), and executive(Wisconsin Card Sorting Test: WCST) tests were administered. The schizotypal-trait group demonstrated significantly prolonged response time on the word-reading task of the Stroop test and poorer concentration performance of the d2 test than both the obsessive-compulsive trait and control groups. In addition, the schizotypal-trait and obsessive-compulsive trait groups exhibited more total errors, perseverative responses and perseverative errors on the WCST. In other words, the schizotypal-trait group demonstrated deficits in attention, memory and executive function, whereas the obsessive-compulsive trait group showed deficits in executive function only. In addition, the obsessive-compulsive trait group exhibited significantly higher scores on SPQ than normal controls, while the schizotypal-trait group demonstrated higher scores on the MOCI and PI than normal controls. These neuropsychological and behavioral results indicate that both schizotypal-trait and obsessive-compulsive trait groups share common cognitive deficits, i.e., deficits in executive function, and symptoms.

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