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폴리라이신아스팔틱산 (PLA)과 그 유도체를 담지한나노 입자의 주름 개선 효과에 관한 연구

New Anti-aging and Anti wrinkle material : Properties and activites of nanoparticle using poly(aspartic acid) derivatives

장혜인|지홍근|우영롱|유효경
한국화장품미용학회 (The Korean Society of Cosmetics and Cosmetology)|2016.06|한국화장품미용학회지 (Korean Society of Cosmetics and Cosmetology)|제6권 제1호|pp. 57-71

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Abstract

Polymers such as polyacrylate, polysaccharide, polyamino acid and polypeptide are widely used in cosmetics and pharmaceutical. They used for viscosity agent, emulsify agent and carriers for delivery of drugs. However We studied polymer as activity agent, especially synthesized poly(aspartic acid). Poly(aspartic acid) is one of biocompatible synthetic polymer and is water-soluble polyamide containing carboxylic pendants that can be prepared form polysuccinimide, the polycondensate of aspartic acid monomer, by hydrolysis. In this study, we prepared the poly(aspartic acid) derivatives conjugated with L-lysine or L-lyine and other materials. The chemical sturucture of these polymers were conformed by FT-IR and 1H-NMR spectroscopy. And we could estimate that these novel poly(aspartic acid) derivatives had the stimulation effect of type Ⅰ collagen biosynthesis and MMP-1(collagenase) inhibition activity.

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