돈태반 추출물의 미백과 주름개선 효능 연구
Study on the Anti-Melanogenic Effect of Porcine Placenta Extract
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본 연구에서는 돈태반 추출물의 미백효능과 주름개선 효능을 알아보았다. 미백활성은 melan-a 세포에서 멜라닌 생성 저해 평가와 tyrosinase 활성 억제 평가를 통하여 확인하였다. 그 결과, 돈태반 추출물은 우수한멜라닌 합성 저해 효과와 tyrosinase 억제 효능을 나타냈다. 멜라닌 생성 억제기전을 확인하기 위해western blot을 실시한 결과 본 소재는 tyrosinase와 microphthalamia associated transcription factor (MITF)의 단백질 발현을 억제하였다. 한편 본 소재는 인체 섬유아세포에서 유형 Ⅰ procollagen 합성을 증가시켰다. 이상의 결과에서 돈태반 추출물은 미백효능과 주름개선 효능을 갖는 화장품 소재로 활용 가능성이 클 것으로 사료된다.
Abstract
The effet of porcine placenta extract (PE) on melanin synthesis and procollagen synthesis were studied. PE treatment reduced melanin contents and tyrosinase activity in melan-a melanocytes. The expressions of tyrosinase and microphthalamia associated transcription factor (MITF) were reduced by PE treatment in melan-a. PE treatment increased type Ⅰ procollagen synthesis in human dermal fibroblast cells. These results suggest that PE has a potential for cosmetic agent with whitening and anti-wrinkle effect
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