발효 오갈피나무 수피의 리그난 비당체고농도 함유 조건 최적화
Optimal Condition for High Concentrations of Lignan Aglycon from Fermented Acanthopanacis Caulis Cortex(Acanthopanax sessiliflorus)
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초록
The purpose of the study is to develop a new process to manufacture high content of lignan aglycon (syringaresinol) from Acanthopanacis Caulis Cortex (Acanthopanax sessiliflorus) extract. Saccharomyces cerevisiae liquid culture fermentation transformed glycoside component (eleutheroside E and E1) of Acanthopanacis Caulis Cortex into aglycon component (syringaresinol). The transformation process from lignan glycosides to lignan aglycon was monitored by HPLC to optimize the fermentation conditions. AS-48 (liquid cultured mixture by Saccharomyces cerevisiae for 48 hours at 28 ℃) had the highest content of syringaresinol (9.411%). However, other mixtures (AS-24, AS-72, AS-144, and AS-168) had less than 9.0% in the content of syringaresinol. However, unfermented Acanthopanacis Caulis Cortex (AS) did not contain syringaresinol.
Abstract
The purpose of the study is to develop a new process to manufacture high content of lignan aglycon (syringaresinol) from Acanthopanacis Caulis Cortex (Acanthopanax sessiliflorus) extract. Saccharomyces cerevisiae liquid culture fermentation transformed glycoside component (eleutheroside E and E1) of Acanthopanacis Caulis Cortex into aglycon component (syringaresinol). The transformation process from lignan glycosides to lignan aglycon was monitored by HPLC to optimize the fermentation conditions. AS-48 (liquid cultured mixture by Saccharomyces cerevisiae for 48 hours at 28 ℃) had the highest content of syringaresinol (9.411%). However, other mixtures (AS-24, AS-72, AS-144, and AS-168) had less than 9.0% in the content of syringaresinol. However, unfermented Acanthopanacis Caulis Cortex (AS) did not contain syringaresinol.
참고문헌 (32)
- T. Namba, "The Encyclopedia of Wakan-Yaku with Color Pictures (Ⅱ)", pp.135~ (1980), Hoikusha
- 육창수, "아세아 생약도감", pp.361~ (1997), 도서출판 경원
- B. E. Shan, "Experimental study on anti-tumor effects of cortex Acanthopanacis senticosus in vivo and in vitro", Zhongguo Zhong Xi Yi Jie He Za Zhi, 24, pp.55~ (2004)
- J. Fu, "Anti-diabetic activities of Acanthopanax senticosus polysaccharide (ASP) in combination with metformin", Int. J. Biol. Macromol., 50, pp.619~ (2012)
- Sang Hyun Park, "Acanthopanax senticosus Reverses Fatty Liver Disease and Hyperglycemia in ob", ob Mice, 2006, pp.29(9), 768~776[DOI]
- L. Z. Huang, "Antifatigue activity of the liposoluble fraction from Acanthopanax senticosus", Phytother. Res, 25, pp.940~ (2011)
- Youn-Soo Cha, "Acanthopanax senticosus Extract Prepared from Cultured Cells Decreases Adiposity and Obesity Indices in C57BL", 6J Mice Fed a High Fat Diet, 2004, pp.7(4), 422~429[DOI]
- 이상현, "Anti-Oxidant Activities of Acanthopanax senticosus Stems and Their Lignan Components", Archives of Pharmacal Research, 27(1), pp.106~110 (2004), 대한약학회
- H. J. Jung, "In vivo anti-inflammatory and antinociceptive effects of liriodendrin isolated from the stem bark of Acanthopanax senticosus", Planta Med, 69, pp.610~ (2003)
- J. M. Yi, "Effect of Acanthopanax senticosus stem on mast cell-dependent anaphylaxis", J. Ethnopharmacol, 79, pp.347~ (2002)
- Y. S. Ovodov, "The glycosides of Eleutherococcus senticosus Max. I. Isolation and some properties of eleutherosides B and E", Khim. prirodn. soedin, 1, pp.3~ (1996)
- Y. S. Ovodov, "Triterpenoidal glycosides of Eleuterococcus sessiliflorus leaves Ⅱ", Khim. Prirodnih. Soedin, 1, pp.618~ (1971)
- L. S. Zhao, "Simulataneous determination of six constituents in the fruit of Acanthopanax sessiliflorus (Rupr. et maxim.) seem. by HPLC-UV", Natural Product Research, 7, pp.500~ (2014)
- C. He, "Eleutheroside E ameliorates arthritis severity in collagen-induced arthritis mice model by suppressing inflammatory cytokine release", Inflammation, 5, pp.1533~ (2014)
- J. Ahn, "Eleutheroside E, an active component of Eleutherococcus senticosus, ameliorates insulin resistance in type 2 diabetic db", db mice, 2013, 934183~
- N. Lall, "Cytotoxicity of syringin and 4-methoxycinnamyl alcohol isolated from Foeniculum vulgare on selected human cell lines", Nat. Prod. Res, 29, pp.1752~ (2015)
- X. Gong, "Hepatoprotective effects of syringin on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice", J. Appl. Toxicol., 34, pp.265~ (2014)
- Y. Y. Song, "Therapeutic effect of syringin on adjuvant arthritis in rats and its mechanisms", Yao Xue Xue Bao, 45, pp.1006~ (2010)
- C. Li, "Determination of eleutheroside B in antifatigue fraction of Acanthopanax senticosus by HPLC", Zhongguo Zhong Yao Za Zhi, 33, pp.2800~ (2008)
- H. S. Niu, "Hypoglycemic effect of syringin from Eleutherococcus senticosus in streptozotocin-induced diabetic rats", Planta Med, 74, pp.109~ (2008)
- J. Choi, "Anti-inflammatory and antinociceptive effects of sinapyl alcohol and its glucoside syringin", Planta Med, 70, pp.1027~ (2004)
- Min-Ja Park, "Fermented Acanthopanax koreanum Root Extract Reduces UVB- and H2O2-Induced Senescence in Human Skin Fibroblast Cells", Journal of Microbiology and Biotechnology, 26(7), pp.1224~1233 (2016), 한국미생물·생명공학회[DOI]
- W. J. Yoon, "Acanthoic acid inhibits melanogenesis through tyrosinase downregulation and melanogenic gene expression in B16 melanoma cells", Nat. Prod. Commun, 8, pp.1359~ (2013)
- 유수연, "Photoprotective Potential of Anthocyanins Isolated from Acanthopanax divaricatus Var. albeofructus Fruits against UV Irradiation in Human Dermal Fibroblast Cells", Biomolecules & Therapeutics, 20(2), pp.201~206 (2012), 한국응용약물학회
- H. R. Choi, "Phlorizin, an Active Ingredient of Eleutherococcus senticosus, Increases Proliferative Potential of Keratinocytes with Inhibition of MiR135b and Increased Expression of Type IV Collagen", Oxid. Med. Cell. Longev., pp.3859721~ (2016)
- J. S. Kang, "Quantitative determination of eleutheroside B and E from Acanthopanax species by high performance liquid chromatography", Arch. Pharm. Res, 24, pp.407~ (2001)
- W. G. Erich, "Chinese drug monographs and analysis (1996-2006)", pp.3~ (2007), Verlag für Ganzheitliche Medizin
- S. Cho, "Syringaresinol protects against hypoxia", reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism, 2015, pp.6, 43~
- Byung-Hee Chung, "Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase", Experimental and Molecular Medicine, 44(3), pp.191~201 (2012), 생화학분자생물학회
- B. Y. Park, "(-)-Syringaresinol inhibits proliferation of human promyelocytic HL-60 leukemia cells via G1 arrest and apoptosis", Int. Immunopharmacol, 8, pp.967~ (2008)
- M. Miyazawa, "Inhibition of Helicobacter pylori motility by (+)-Syringaresinol from unripe Japanese apricot", Biol. Pharm. Bull, 29, pp.172~ (2006)
- 김주원, "Effects of Korean ginseng berry on skin antipigmentation and antiaging via FoxO3a activation", Journal of Ginseng Research, 41(3), pp.277~283 (2017), 고려인삼학회[DOI]
