Easy Detection of Amyloid -Protein Using Photo-Sensitive Field Effect
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This article describes a novel method for the detection of amyloid- (A ) peptide that utilizes a photo-sensitive field-effect transistor (p-FET). According to a recent study, A protein has been known to play a central role in the pathogenesis of Alzheimer’s disease (AD). Accordingly, we investigated the variation of photo current generated from p-FET with and without intracellular magnetic beads conjugated with A peptides, which are placed on the p-FET sensing areas. The decrease of photo current was observed due to the presence of the magnetic beads on the channel region. Moreover, a similar characteristic was shown when the Raw 264 cells take in magnetic beads treated with A peptide. This means that it is possible to simply detect a certain protein using magnetic beads and a p-FET device. Therefore, in this paper, we suggest that our method could detect tiny amounts of A for early diagnosis of AD using the p-FET devices.
Abstract
This article describes a novel method for the detection of amyloid- (A ) peptide that utilizes a photo-sensitive field-effect transistor (p-FET). According to a recent study, A protein has been known to play a central role in the pathogenesis of Alzheimer’s disease (AD). Accordingly, we investigated the variation of photo current generated from p-FET with and without intracellular magnetic beads conjugated with A peptides, which are placed on the p-FET sensing areas. The decrease of photo current was observed due to the presence of the magnetic beads on the channel region. Moreover, a similar characteristic was shown when the Raw 264 cells take in magnetic beads treated with A peptide. This means that it is possible to simply detect a certain protein using magnetic beads and a p-FET device. Therefore, in this paper, we suggest that our method could detect tiny amounts of A for early diagnosis of AD using the p-FET devices.
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