센서 어레이를 사용한 COPD 환자의 호기분석
Analysis of COPD Patient's Exhaled Breath Using Sensor Array
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초록
The exhaled breath contains gases generated from human body. When disease occurs in the body, exhaled breath may include gas components released from disease metabolism. If we can find specific elements through analysis of the exhaled gases, this approach is an effective way to diagnose the disease. The lung function has a close relationship with exhalation. Exhaled gases from COPD (Chronic Obstructive Pulmonary Disease) patients can be analyzed by gas chromatography-mass spectroscopy (GC-MS) and a gas sensor system. The exhaled breath for healthy person and COPD patients had different components. Significantly more benzendicarboxylic acid was detected from COPD patients than in healthy persons. In addition, patients had a variety of decane. Phosphorous compounds with different isomers were detected from patients. The results obtained by gas sensor system were processed by PCA (Principal Component Analysis). The PCA results revealed distinct difference between the patients and healthy people.
Abstract
The exhaled breath contains gases generated from human body. When disease occurs in the body, exhaled breath may include gas components released from disease metabolism. If we can find specific elements through analysis of the exhaled gases, this approach is an effective way to diagnose the disease. The lung function has a close relationship with exhalation. Exhaled gases from COPD (Chronic Obstructive Pulmonary Disease) patients can be analyzed by gas chromatography-mass spectroscopy (GC-MS) and a gas sensor system. The exhaled breath for healthy person and COPD patients had different components. Significantly more benzendicarboxylic acid was detected from COPD patients than in healthy persons. In addition, patients had a variety of decane. Phosphorous compounds with different isomers were detected from patients. The results obtained by gas sensor system were processed by PCA (Principal Component Analysis). The PCA results revealed distinct difference between the patients and healthy people.
참고문헌 (9)
- D. J. Penn, "Individual and gender fingerprints in human body odour", Journal of the Royal Society Interface (2006)[DOI]
- M. Phillips, "Variation in volatile organic compounds in the breath of normal humans", Journal of Chromatography B, 729, pp.75~88 (1999)
- J. W. Gardner, "An electronic nose system to diagnose illness", Sens. Actuator B-Chem, 70, pp.19~24 (2000)
- Y. Lee, "Fabrication of clinical gas sensor using MEMS process", SENSORS AND ACTUATORS B-CHEMICAL, 108, pp.292~297 (2005), ELSEVIER SCIENCE SA
- A. Amann, "Breath analysis: the approach towards clinical applications", Mini. Rev. Med. Chem, 7(2), pp.115~129 (2007)
- 유준부, "Exhaled Breath Analysis of Lung Cancer Patients Using a Metal Oxide Sensor", 센서학회지, 20(5), pp.300~304 (2011), 한국센서학회
- C. Grote, "Solid-phase microextraction for the analysis of human breath", Anal. Chem, 69, pp.587~596 (1997)
- J. J. B. N, "A profile of volatile organic compounds in breath discriminates COPD patients from controls", Respiratory Medicine, 104, pp.557~563 (2010)
- C. Grote, "Solid-phase microextraction for the analysis of human breath", Anal. Chem, 69, pp.587~596 (1997)