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후두에서 기원한 IgG4 연관 가성 종양 1예

A Case of IgG4-Related Pseudotumor in Larynx

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초록

IgG4-related disease is a fibroinflammatory condition by infiltration of IgG4-positive plasma cells that often presents as a tumorous lesion. This disease can affect nearly every organ system. After the pancreas, the head and neck region is second most common site for presentation of IgG4- related disease such as Mikulicz’s disease, Küttner tumor. The involvement of IgG4-related disease in laryngeal lesions is extremely rare. We have experienced a case of IgG4-related disease with pseudotumor formation in the larynx that is suggestive of malignancy in radiologic findings. But the pathology findings was finally confirmed as IgG4-related disease. Oral treatment with prednisolone was initiated, and the edematous mass reduced in size without permanent functional impairment of vocal fold mobility. We report our experience with a literature review.

Abstract

IgG4-related disease is a fibroinflammatory condition by infiltration of IgG4-positive plasma cells that often presents as a tumorous lesion. This disease can affect nearly every organ system. After the pancreas, the head and neck region is second most common site for presentation of IgG4- related disease such as Mikulicz’s disease, Küttner tumor. The involvement of IgG4-related disease in laryngeal lesions is extremely rare. We have experienced a case of IgG4-related disease with pseudotumor formation in the larynx that is suggestive of malignancy in radiologic findings. But the pathology findings was finally confirmed as IgG4-related disease. Oral treatment with prednisolone was initiated, and the edematous mass reduced in size without permanent functional impairment of vocal fold mobility. We report our experience with a literature review.

참고문헌 (11)

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  3. 윤형준, "비인두암으로 오인된 Immunoglobulin G4 연관 경화성 질환 2예", 대한이비인후-두경부외과학회지, 59(4), pp.304~308 (2016), 대한이비인후과학회[DOI]
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  8. Khosroshahi A, "International consensus guidance statement on the management and treatment of IgG4-related disease", Arthritis Rheumatol, 67(7), pp.1688~1699 (2015)
  9. Lee CM, "Retrospective singlecentre analysis of IgG4-related disease patient population and treatment outcomes between 2007 and 2017", Rheumatol Adv Pract, 3(1), pp.rkz014~ (2019)
  10. Lanzillotta M, "Advances in the diagnosis and management of IgG4 related disease", BMJ, 369, pp.m1067~ (2020)
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