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當歸飮子 加減方의 처방별 (A, B) 아토피성 알레르기반응 조절 효과 비교 연구

A Comparative Study of Regulatory Effect of Atopic Allergic Reaction by Prescriptions (A, B)

박은정|이해자|한경훈
대한한방소아과학회 (The Association of Pediatrics of Korean Medicine)|2005.12|대한한방소아과학회지 (The Journal of Pediatrics of Korean Medicine)|제19권 제2호|pp. 13-30

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주제분류한의학

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Abstract

Objective : Danguieumja-gagambang (DGEJGB), a traditional Korean prescription, has been used as therapeutics for allergic diseases such as atopic dermatitis (AD). In this study, we compared with regulatory Effect of Atopic Allergic Reaction by Prescriptions A and by Prescriptions B. Methods : To evaluate and compare the atopic allergic effectiveness of two prescription (A, B) of DGEJGB, the author investigated a possible effect of DGEJGB on mast cell-mediated allergic reaction, cytokine secretion and mRNA expression in vivo and in vitro. Results : Mast cells are a potent source of mediators that regulate the inflammatory response in allergic reaction. In mice orally administered A, B of DGEJGB (0.01, 0.1 and 1.0 g/kg) for 1 h, compound 48/80-induced ear swelling was significantly reduced. Significant reduced levels (P < 0.05) of tumor necrosis factor (TNF)-α was observed in the human mast cell line (HMC-1) with DGEJGB (A). IL-6 and IL-8 secretion were significantly inhibited by DGEJGB (A, B). In addition, TNF-α and IL-8 mRNA expression were reduced by DGEJGB (A) at the dose of 0.01 mg/ml without cell toxicity. Conclusions : These results suggest that DGEJGB (A) contributes to the treatment of atopic allergic reactions rather than DGEJGB (B), and that its action may be due to inhibition of cytokine secretion and mRNA expression HMC-1.

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