柴梗淸肺湯 및 通竅湯加味方이 기도점액분비 및 기관평활근 긴장도에 미치는 영향
Effects of Sigyoungcheongpyetang and Tonggyutanggamibang on airway mucus secretion
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Abstract
Objective： To investigate the effectiveness of two oriental medical prescriptions named Sigyoungcheongpyetang(SCPT) and Tonggyutanggamibang(TGT) for mucin release from cultured hamster tracheal surface epithelial(HTSE) cells. Method： Confluent HTSE cells were metabolically radiolabeled with 3H-glucosamine for 24 hrs and chased for 30 min in the presence of SCPT or TGT to assess the effect of each agent on 3H-mucin release. Possible cytotoxicities of each agent were assessed by measuring lactate dehydrogenase(LDH) release. Also, the effects of SCPT and TGT on contractility of isolated tracheal smooth muscle were investigated. Results： (1) SCPT and TGT significantly increased mucin release from cultured HTSE cells, with significant cytotoxicity ; SCPT did not affect contractility of isolated tracheal smooth muscle and TGT inhibited Ach-induced contraction of isolated tracheal smooth muscle. Conclusion： We suggest that the effects of SCPT and TGT with their components should be further investigated and it is of great value to find, from oriental medical prescriptions, novel agents which might regulate mucin secretion from airway goblet cells.
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