관동화 및 관동화 가미방이 흰쥐의 간독성 및 신독성에 미치는 영향
Studies on Hepatic and Renal Toxicities Possibly Induced by Administration of Farfarae Flos in Rats
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Objectives This study is to investigate whether oral administration of Farfarae flos, JCT (Jeong-cheon-tang), CPT (Cheong-pye-tang) and CPK (Cheong-pye-tang- ga-kwandonghwa) will affect both the levels of serum GOT, GPT, blood urea nitrogen (BUN) and creatinine in SD rats or not, and will change body weight of the rats. Materials and Methods 18 SD rats were randomly divided into 6 groups . including a control group (vehicle 2 ml/rat), Farfarae flos water extract (extract 2 ml/rat), Farfarae flos fine powder (emulsion 2 ml/rat), JCT (extract 2 ml/rat), CPT (extract 2 ml/rat) and CPK (extract 2 ml/rat) group. The drugs were administered to rats for 2 weeks or 30 days (for control and Farfarae flos fine powder group only) and serum GOT/GPT activities and BUN/creatinine concentrations were measured. Also, the changes of body weights of each rat was measured. Results (1) Farfarae flos water extract, Farfarae flos fine powder emulsion, JCT and CPT and CPK did not cause any changes in serum GOT/GPT activities and BUN/creatinine concentrations compared to the ones in control group. (2) There are no significant changes in rats’ body weight among the experimental groups during the experimental period. Conclusions Contrary to the reports on human data, 2 weeks or 30 days of oral administrations of Farfarae flos itself and decoctions containing Farfarae flos did not provoke hepatotoxicity and nephrotoxicity.
Abstract
Objectives This study is to investigate whether oral administration of Farfarae flos, JCT (Jeong-cheon-tang), CPT (Cheong-pye-tang) and CPK (Cheong-pye-tang- ga-kwandonghwa) will affect both the levels of serum GOT, GPT, blood urea nitrogen (BUN) and creatinine in SD rats or not, and will change body weight of the rats. Materials and Methods 18 SD rats were randomly divided into 6 groups . including a control group (vehicle 2 ml/rat), Farfarae flos water extract (extract 2 ml/rat), Farfarae flos fine powder (emulsion 2 ml/rat), JCT (extract 2 ml/rat), CPT (extract 2 ml/rat) and CPK (extract 2 ml/rat) group. The drugs were administered to rats for 2 weeks or 30 days (for control and Farfarae flos fine powder group only) and serum GOT/GPT activities and BUN/creatinine concentrations were measured. Also, the changes of body weights of each rat was measured. Results (1) Farfarae flos water extract, Farfarae flos fine powder emulsion, JCT and CPT and CPK did not cause any changes in serum GOT/GPT activities and BUN/creatinine concentrations compared to the ones in control group. (2) There are no significant changes in rats’ body weight among the experimental groups during the experimental period. Conclusions Contrary to the reports on human data, 2 weeks or 30 days of oral administrations of Farfarae flos itself and decoctions containing Farfarae flos did not provoke hepatotoxicity and nephrotoxicity.
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