소아청소년 편두통의 경구 한약 치료에 대한 임상 연구 동향 분석 - 2010년 이후 무작위 대조연구를 중심으로 -
Research Trends in Oral Herbal Medicine for Migraine in Child and Adolescents - Focused on Randomized Controlled Trials -
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Objectives This study aimed to analyze the research trends and evaluate the efficacy and safety of herbal medicine treatments for pediatric and adolescent migraines by reviewing randomized controlled trials. Methods This review of randomized controlled trials of herbal medicines for pediatric patients with migraines was conducted using nine databases. Studies involving patients under 20 years of age who used oral herbal treatments were included, whereas those involving secondary headaches and other comorbidities were excluded. Patient characteristics, interventions, and outcomes were analyzed. Results Eleven RCTs were included, comprising 1,114 pediatric patients with migraines aged 5-18 years. Studies have primarily used herbal formulations such as the Xiongzhi Qufeng mix and evaluated outcomes through total effective rate (TER) and transcranial Doppler (TCD) assessments. The TER was significantly higher in the herbal treatment groups than in the control groups (P < 0.05), and the TCD results suggested improved cerebral blood flow in the treatment groups. Only one study reported mild adverse effects, which limited the safety evaluation. Variations in the study design, interventions, and diagnostic criteria highlight the need for standardized and long-term safety evaluations in future research. Conclusion Herbal medicine has the potential to be an effective complementary treatment for pediatric migraines. However, standardized studies and long-term evaluations must establish consistent evidence of their efficacy and safety.
Abstract
Objectives This study aimed to analyze the research trends and evaluate the efficacy and safety of herbal medicine treatments for pediatric and adolescent migraines by reviewing randomized controlled trials. Methods This review of randomized controlled trials of herbal medicines for pediatric patients with migraines was conducted using nine databases. Studies involving patients under 20 years of age who used oral herbal treatments were included, whereas those involving secondary headaches and other comorbidities were excluded. Patient characteristics, interventions, and outcomes were analyzed. Results Eleven RCTs were included, comprising 1,114 pediatric patients with migraines aged 5-18 years. Studies have primarily used herbal formulations such as the Xiongzhi Qufeng mix and evaluated outcomes through total effective rate (TER) and transcranial Doppler (TCD) assessments. The TER was significantly higher in the herbal treatment groups than in the control groups (P < 0.05), and the TCD results suggested improved cerebral blood flow in the treatment groups. Only one study reported mild adverse effects, which limited the safety evaluation. Variations in the study design, interventions, and diagnostic criteria highlight the need for standardized and long-term safety evaluations in future research. Conclusion Herbal medicine has the potential to be an effective complementary treatment for pediatric migraines. However, standardized studies and long-term evaluations must establish consistent evidence of their efficacy and safety.