만성 감초 중독으로 유발된 미네랄코르티코이드 과잉증후군 1예
A case of chronic licorice intoxication-induced apparent mineralocorticoid excess syndrome
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Licorice is a perennial herb belonging to the legume family that mainly grows in northeastern China,Mongolia, Siberia, and other regions. It is used in traditional medicine in the form of dried roots in theEast and the West. The main active component of licorice, glycyrrhizin, is known to produce mineralocor ticoid effects when consumed chronically, which can lead to apparent mineralocorticoid excess syn drome. Herein, we present the case of a 72-year-old woman who was admitted to the emergency roomwith severe generalized weakness and difficulty keeping her neck upright, which had developed after dai ly consumption of licorice-infused water for the past 2 months. Blood tests revealed metabolic alkalosisand severe hypokalemia, and an electrocardiogram showed ventricular bigeminy. The patient was treatedwith daily potassium and spironolactone supplements, leading to a significant improvement in musclestrength after a week. One week later, the patient was discharged, showing rare ventricular prematurecontractions on electrocardiography, but with no specific complaints. Chronic licorice ingestion leadingto hypokalemia and muscle weakness can be life-threatening, necessitating the discontinuation of thecausative agent, close monitoring, and cautious supplementation of potassium and spironolactone astreatment.
Abstract
Licorice is a perennial herb belonging to the legume family that mainly grows in northeastern China,Mongolia, Siberia, and other regions. It is used in traditional medicine in the form of dried roots in theEast and the West. The main active component of licorice, glycyrrhizin, is known to produce mineralocor ticoid effects when consumed chronically, which can lead to apparent mineralocorticoid excess syn drome. Herein, we present the case of a 72-year-old woman who was admitted to the emergency roomwith severe generalized weakness and difficulty keeping her neck upright, which had developed after dai ly consumption of licorice-infused water for the past 2 months. Blood tests revealed metabolic alkalosisand severe hypokalemia, and an electrocardiogram showed ventricular bigeminy. The patient was treatedwith daily potassium and spironolactone supplements, leading to a significant improvement in musclestrength after a week. One week later, the patient was discharged, showing rare ventricular prematurecontractions on electrocardiography, but with no specific complaints. Chronic licorice ingestion leadingto hypokalemia and muscle weakness can be life-threatening, necessitating the discontinuation of thecausative agent, close monitoring, and cautious supplementation of potassium and spironolactone astreatment.
참고문헌 (10)
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