국내 유통 감초의 글리시리진 함량 및 약리적 문제에 관한 고찰
A Study on the Pharmacological Problems and Glycyrrhizin of Licorice Distributed in Korea
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Background: Scarcity of wild licorice, which is most commonly used in oriental medicine, has led to an increase in the use of various other licorice species. Diversification of licorice species can affect the quality, safety, and standardization of food and medicine; therefore, it is crucial to verify and evaluate their major pharmacological components. Methods and Results: In this study, we collected licorice produced and distributed in various regions of Asia, including Korea, and compared the content of glycyrrhizin. The average glycyr- rhizin content of wild licorice produced in China (Yangoe), Uzbekistan, Kyrgyzstan, and Kazakh- stan was 3.2%, 5.5%, 5.5%, and 5.3%, respectively. In contrast, the average glycyrrhizin content of cultivated licorice from Xinjiang, China and Jecheon, Korea was 4.8% and 0.8%, respectively. The glycyrrhizin content of each licorice slice ranged from 1.0% to 12.4%. Wild licorice, in particular, had a high glycyrrhizin content and variation. In addition to pharmacological effects, glycyrrhizin has various side effects; therefore, the quality of wild licorice, which has been traditionally regarded as good, needs to be re-evaluated. Conclusions: In terms of the stability of food and pharmaceutical raw materials, licorice with uni- formity and appropriate content of glycyrrhizin is more effective in controlling and utilizing the pharmacology than licorice with considerably high glycyrrhizin content. To this end, it is crucial to shift production from wild licorice collection to cultivated licorice and develop related cultivation technologies.
Abstract
Background: Scarcity of wild licorice, which is most commonly used in oriental medicine, has led to an increase in the use of various other licorice species. Diversification of licorice species can affect the quality, safety, and standardization of food and medicine; therefore, it is crucial to verify and evaluate their major pharmacological components. Methods and Results: In this study, we collected licorice produced and distributed in various regions of Asia, including Korea, and compared the content of glycyrrhizin. The average glycyr- rhizin content of wild licorice produced in China (Yangoe), Uzbekistan, Kyrgyzstan, and Kazakh- stan was 3.2%, 5.5%, 5.5%, and 5.3%, respectively. In contrast, the average glycyrrhizin content of cultivated licorice from Xinjiang, China and Jecheon, Korea was 4.8% and 0.8%, respectively. The glycyrrhizin content of each licorice slice ranged from 1.0% to 12.4%. Wild licorice, in particular, had a high glycyrrhizin content and variation. In addition to pharmacological effects, glycyrrhizin has various side effects; therefore, the quality of wild licorice, which has been traditionally regarded as good, needs to be re-evaluated. Conclusions: In terms of the stability of food and pharmaceutical raw materials, licorice with uni- formity and appropriate content of glycyrrhizin is more effective in controlling and utilizing the pharmacology than licorice with considerably high glycyrrhizin content. To this end, it is crucial to shift production from wild licorice collection to cultivated licorice and develop related cultivation technologies.
참고문헌 (40)
- Armanini D, "History of the endocrine effects of licorice", Experimental and Clinical Endocrinology and Diabetes, 110, pp.257~261 (2002)
- Bramont C, "Cerebral vascular accident caused by alcohol-free licorice", La Presse Médicale, 14, pp.746~ (1985)
- Cartier A, "Occupational asthma due to liquorice roots", Allergy, 57, pp.863~ (2002)
- 최고야, "동북아 각국 공정서의 한약재 규격 기준 비교(4) - 감초", 한약정보연구회지(韓藥情報硏究會誌), 3(2), pp.17~26 (2015), 한약정보연구회[DOI]
- Dobbins KR, "Transient visual loss after licorice ingestion", Journal of Neuro-opthalmology, 20, pp.38~41 (2000)
- Egamberdieva D, "A synergistic interaction between salt-tolerant Pseudomonas and Mesorhizobium strains improves growth and symbiotic performance of liquorice(Glycyrrhiza uralensis Fish. )under salt stress", Applied Microbiology and Biotechnology, 100, pp.2829~2841 (2016)
- Fraunfelder FW, "Ocular side effects from herbal medicines and nutritional supplements", American Journal of Ophthalmology, 138, pp.639~647 (2004)
- Furukawa Z, "Settings and geo-environmental conditions of developed greening soil materials(GSM)for cultivating licorice(Glycyrrhiza uralensis Fisch. )in Mongolian arid region", Journal of Arid Land Studies, 25, pp.105~108 (2015)
- Hall RC, "Central retinal vein occlusion associated with liquorice ingestion", Clinical and Experimental Ophthalmology, 32, pp.341~ (2004)
- Harada T, "Congestive heart failure caused by digitalis toxicity in an elderly man taking a licorice0containing Chinese herbal laxative", Cardiology, 98, pp.218~ (2002)
- Hayashi H, "Field survey of Glycyrrhiza plants in Central Asia(1). Characterization of G. uralensis, G. glabra and the putative intermediate collected in Kazakhstan", Biological and Pharmaceutical Bulletin, 26, pp.867~871 (2003)
- Hayashi H, "Field survey of Glycyrrhiza plant in Central Asia(2). Charac-terization of phenolics and their variation in the leaves of Glycyrrhiza plants collected in Kazakhstan", Chemical and Pharmaceutical Bulletin, 51, pp.1147~1152 (2003)
- Hong ND, "Quality control of herbal medicines", pp.87~ (2007), Shinilbooks
- Karkanis A, "Phytochemical composition, health effects, and crop management of liquorice(Glycyrrhiza glabra L. ) : A medicinal plant", Food Reviews International, 34, pp.182~203 (2016)
- Kent UM, "The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6 and 2C9", Drug Metabolism and Disposition, 30, pp.709~715 (2002)
- 김용일, "온도구배터널에서 기온상승에 따른 신품종 감초 원감 (Glycyrrhiza glabra × Glycyrrhiza uralensis)의 생육, 수량, 약리성분 특성 및 국내 재배적지에 관한 연구", 원예과학기술지, 38(1), pp.44~55 (2020), 한국원예학회
- 김용일, "온도구배터널에서 기온상승에 따른 만주감초의 생육, 수량, 약리성분 특성에 관한 연구", 한국약용작물학회지, 27(5), pp.322~329 (2019), 한국약용작물학회[DOI]
- Kobayashi T, "Field surveys of soil conditions in steppe of northeastern Mongolia", Journal of Arid Land Studies, 22, pp.25~28 (2012)
- Korean medicinal materials, "Korea Institute of Oriental Medicine(KIOM)", Korea Institute of Oriental Medicine, 8~15 (2015)
- Marui A, "Monitoring the growing environment of wild licorice with analysis of satellite data at a semi-arid area in Mongolia", Journal of Arid Land Studies, 24, pp.199~202 (2014)
- Ministry of Agriculture, Food and Rural Affairs(MAFRA), "2021 Production data of industrial crops", Ministry of Agriculture, Food and Rural Affairs, 6~ (2022)
- "Licorice grows better in Korea than in central Asia and China" (2020)[URL]
- Ministry of Food and Drug Safety(MFDS), "Chinese herbal medicine production information", Ministry of Food and Drug Safety, 1~256 (2009)
- Ministry of Food and Drug Safety(MFDS), "The Korean pharmacopoeia", Monographs. Ministry of Food and Drug Safety, 1321~ (2012)
- Ministry of Food and Drug Safety(MFDS), "The Korean Pharmacopoeia", The MFDS notification. No. 2014- 194. Ministry of Food and Drug Safety, 1~328 (2014)
- A study on the consumption pattern and pricing structure of major oriental medicines in Korea, "Ministry of Health and Welfare(MOHW)", Ministry of Health and Welfare, 103~ (2001)
- Olukoga A, "Liquorice and its health implications", The Journal of the Royal Society for the Promotion of Health, 120, pp.83~89 (2000)
- Omar HR, "Licorice abuse : Time to send a warning message", Therapeutic Advances in Endocrinology and Metabolism, 3, pp.125~138 (2012)
- Park CG, "Development of cultural practices in Glycyrrhiza uralensis Fisch", Crop Research Bulletin, 4, pp.1~17 (2003)
- Study on cultivation environment and production impact assessment of licorice according to climate conditions, "Rural Development Administration(RDA)", Rural Development Administration, 1~137 (2020)
- Russo S, "Low doses of liquorice can induce hypertension encephalopathy", American Journal of Nephrology, 20, pp.145~148 (2000)
- Sailler L, "Generalized edema caused by licorice : A new syndrome. Apropos of 3 cases", La Revue de Medecine Interne, 14, pp.984~ (1993)
- Santaella RM, "Ocular adverse effects associated with systemic medications : Recognition and management", Drugs, 67, pp.75~93 (2007)
- Tacconi P, "Carpal tunnel syndrome triggered by excessive licorice consumption", Journal of the Peripheral Nervous System, 14, pp.64~65 (2009)
- Thomas Q, "Aldosterone receptor antagonism normalizes vascular function in liquorice-induced hypertension", Hypertension, 37, pp.801~805 (2001)
- Tsukamoto S, "CYP3A4 inhibitors isolated from licorice", Biological and Pharmaceutical Bulletin, 28, pp.2000~2002 (2005)
- Tuvshintogtokh I, "Some results of ecological research of uralian licorice(Glycyrrhiza uralensis Fisch.) in Mongolia", Proceedings of EAEP 2013, 1, pp.98~103 (2013)
- Van der Zwan A, "Hypertension encephalopathy after liquorice ingestion", Clinical Neurology and Neurosurgery, 95, pp.35~37 (1993)
- Yamamoto Y, "Growth and glycyrrhizin contents in Glycyrrhiza uralensis roots cultivated for four years in Eastern Nei-Meng-gu of China", Journal of Traditional Medicine, 19, pp.87~92 (2002)
- Yamamoto Y, "Pharmaceutical evaluation of Glycyrrhiza uralensis roots cultivated in Eastern Nei-Meng-Gu of China", Biological and Pharmaceutical Bulletin, 26, pp.1144~1149 (2003)