경계성고혈압자의 동적 운동 시 혈관내피세포기능
Endothelial function in prehypertensive during dynamic handgrip exercise
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
본 연구의 목적은 동적 운동 시 경계성고혈압자와 정상혈압자를 대상으로 Doppler Ultrasound와 Physio flow를 통한 혈관내피세포기능과 심혈관 반응에 대하여 비교하는 것이다. 본 연구의 가설은 경계성고혈압자가 정상혈압자에 비해 안정 시 FMD(flow-mediated dilation)검사와 핸드그립을 이용한 동적 운동시 혈관내피세포기능이 저하 될 것이다. 연구 참여자는 정상혈압자 10명, 경계성고혈압자 11명으로 20대 남학생으로 선정하였다. 동적 운동은 최대 악력의 30%로 초당 1회 수축하며 총 3분간 실시하였다. 운동 중 혈관의 변화와 심혈관 반응을 지속적으로 살펴보았으며 통계분석은 두 집단을 비교하기 위해 독립 T 검증을 실시하였다. 그 결과, 안정시 혈관직경, FMD시 혈관직경, (%)FMD, 혈류량에는 두 집단 간 차이가 나지 않았다. 동적 운동 시 혈관이완에서 두 집단 간에 차이를 나타내지 않았다. 이러한 결과는 경계성고혈압자는 정상혈압자에 비해 혈관내피세포기능이 저하되어 있음이 시사되었다.
Abstract
The purpose of this study was a investigate the endothelial function of prehypertensive during dynamic exercise. Hypothesis of this study was to impair the endothelial function in prehypertensive compared to normtensive during dynamic handgrip exercise. Eleven healthy prehypertension (24±2 yrs) and ten healthy normotensive (25 ± 2 yrs) were recruited in this study. Participants were performed dynamic handgrip exercise in one contraction per second at 30% of maximum voluntary contraction for three minutes. Vascular (blood vessel diameter, blood flow) and cardiar response (stroke volume, heart rate and cardiac output) were measured at rest and during exercise. Flow mediated dilation (FMD) was decrease significantly in prehypertensive less than normotensive (p<0.05) at rest, and vasodilation of prehypertensive was reduced significantly less than normitensive during exercise (p<0.05). All the cardiovascular responses were aot significantly different at rest and during exercise between prehypertensive and normotensive. These results suggest that endothelial function is impaired in prehypertensive compared to in normotensive
참고문헌 (26)
- Beck, D. T., "Exercise training improves endothelial function in young prehypertensives", Experimental Biology and Medicine, 238(4), pp.433~441 (2013)
- Cernacek, P., "The endothelin system and its role in acute myocardial infarction", Canadian Journal of Physiology and Pharmacology, 81(6), pp.598~606 (2003)
- Choi, H., "Augmentation of the exercise pressor reflex in prehypertension: roles of the muscle metaboreflex and mechanoreflex", Applied Physiology, Nutrition, and Metabolism, 38, pp.209~215 (2013)
- Choi, K. M., "Prevalence of prehypertension and hypertension in a Korean population : Korean National Health and Nutrition Survey(2001)", Journal of Hypertension, 24, pp.1515~1521 (2006)
- Clifford, P. S., "Vasodilatory mechanisms in contracting skeletal muscle", Journal of Applied Physiology, 97(1), pp.393~403 (2004)
- Deanfield, J. E., "Endothelial function and dysfunction testing and clinical relevance", Circulation, 115(10), pp.1285~1295 (2007)
- Egashira, K., "Impaired Endothelium-Dependent Vasodilation of Large Epicardial and Resistance Coronary Arteries in Patients With Essential Hypertension Different Responses to Acetylcholine and Substance P", Hypertension, 25(2), pp.201~206 (1995)
- Eldridge, F. L., "Exercise hyperpnea and locomotion : parallel activation from the hypothalamus", Science, 211, pp.844~846 (1981)
- Gündüz, F., "Exercise training enhances flow-mediated dilation in spontaneously hypertensive rats", Physiological Research, 60, pp.589~597 (2011)
- Higashi, Y., "Aging and severity of hypertension attenuate endothelium-dependent renal vascular relaxation in humans", Hypertension, 30(2), pp.252~258 (1997)
- James, E., "Exercise and Cardiovascular Risk in Patients With Hypertension", American Journal of Hypertension, 28, pp.147~158 (2015)
- Kaufman, M. P., "Effect of ischemia on responses of group III and IV afferents to contraction", Journal of Applied Physiology, 57(3), pp.644~650 (1984)
- Kaufman, M. P., "Reflexes controlling circulatory, ventilatory and airway responses to exercise", Comprehensive Physiology (1996)
- Landmesser, U. 1., "Endothelial function and hypertension", Current Opinion in Cardiology, 22(4), pp.316~320 (2007)
- Lee, Y. C., "Evidence that endothelin-1(ET-1)inhibits insulin-stimulated glucose uptake in rat adipocytes mainly through ETa receptors", Metabolism, 47, pp.1468~1471 (1998)
- Lewis, G. D., "Exercise blood pressure and the risk of incident cardiovascular disease(from the Framingham Heart Study)", The American Journal of Cardiology, 101, pp.1614~1620 (2008)
- Lu, Y., "Lifestyle and Risk of Hypertension : Follow-Up of a Young Pre-Hypertensive Cohort", International Journal of Medicine Science, 12, pp.605~612 (2015)
- Park, S., "Accumulation of physical activity leads to a greater blood pressure reduction than a single continuous session, in prehypertension", Journal of Hypertension, 24(9), pp.1761~1770 (2006)
- Stebbins, C. L., "Cardiovascular responses to static and dynamic contraction during comparable workloads in humans", American Journal of Physiology, 283, pp.568~575 (2002)
- Stewart, K. J., "Cardiac rehabilitation following percutaneous revascularization, heart transplant, heart valve surgery, and for chronic heart failure", Chest Journal, 123(6), pp.2104~2111 (2003)
- Vanhoutte, P. M., "Endothelial dysfunction and vascular disease", Acta Physiologica, 196(2), pp.193~222 (2009)
- Vasan, R. S., "Residual lifetime risk for developing hypertension in middle-aged women and men", JAMA, 287, pp.1003~1010 (2002)
- Waldrop, T. G., "Central neural control of respiration and circulation during exercise", Comprehensive Physiology (1996)
- Weil, B. R., "Prehypertension is associated with impaired nitric oxide-mediated endothelium-dependent vasodilation in sedentary adults", American Journal of Hypertension, 24(9), pp.976~981 (2011)
- Welsman, J., "Reliability of peak\ dot V {\ text {O}} _2 and maximal cardiac output assessed using thoracic bioimpedance in children", European journal of applied physiology, 94(3), pp.228~234 (2005)
- Xu, J. Z., "Impaired endothelial function in hypertensive patients with target organ damage", Journal of Human Hypertension, 23(11), pp.751~757 (2009)