꽈배기모자반 추출물이 3T3-L1 지방세포 분화에 미치는 영향
Inhibitory Effect of Crude Extracts from a Brown Alga Sargassum siliquanstrum on 3T3-L1 Adipocyte Differentiation
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In this study, the potential capacity of the crude extract and its solvent fractions from S. siliquanstrum against adipocyte differentiation were evaluated in 3T3-L1 adipocytes. The anti-adipogenic effect of S. siliquanstrum was evidenced by the fact that its crude extract decreases the lipid accumulation of differentiating cells and the expression levels of crucial adipogenesis markers, peroxisome proliferatoractivated receptor (PPAR)γ and CCAAT/enhancer-binding protein (C/EBP)α. All solvent fractions except the water fraction showed an observable decrease in lipid accumulation and PPARγ and C/EBPα expressions. In conclusion, these results suggest that S. siliquanstrum possesses obesity inhibiting components, which may possibly be used as a valuable anti-obesity agent for reducing the risk of obesity.
Abstract
In this study, the potential capacity of the crude extract and its solvent fractions from S. siliquanstrum against adipocyte differentiation were evaluated in 3T3-L1 adipocytes. The anti-adipogenic effect of S. siliquanstrum was evidenced by the fact that its crude extract decreases the lipid accumulation of differentiating cells and the expression levels of crucial adipogenesis markers, peroxisome proliferatoractivated receptor (PPAR)γ and CCAAT/enhancer-binding protein (C/EBP)α. All solvent fractions except the water fraction showed an observable decrease in lipid accumulation and PPARγ and C/EBPα expressions. In conclusion, these results suggest that S. siliquanstrum possesses obesity inhibiting components, which may possibly be used as a valuable anti-obesity agent for reducing the risk of obesity.
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