Biotechnological Potential of Korean Marine Microalgal Strains and Its Future Prospectives
1
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Marine microalgae have long been used as food additives and feeds for juvenile fish and invertebrates as their nutritional content is beneficial for humans and marine aquaculture species. Recently, they have also been recognized as a promising source for cosmeceutical, nutraceutical, and pharmaceutical products as well as biofuels. Marine microalgae of various species are rich in multiple anti-oxidant phytochemicals and their bioactive components have been employed in cosmetics and dietary supplements. Oil contents in certain groups of marine microalgae are extraordinarily rich and abundant and therefore have been commercialized as omega-3 and omega-6 fatty acid supplements and mass production of microalgaebased biodiesels has been demonstrated by diverse research groups. Numerous natural products from marine microalgae with significant biological activities are reported yearly and this is attributed to their unique adaptive abilities to the great diversity of marine habitats and harsh conditions of marine environments. Previously unknown toxin compounds from red tide-forming dinoflagellates have also been identified which opens up potential applications in the blue biotechnology sector. This review paper provides a brief overview of the biotechnological potentials of Korean marine microalgae. We hope that this review will provide guidance for future marine biotechnology R&D strategies and the various marine microalgae-based industries in Korea.
Abstract
Marine microalgae have long been used as food additives and feeds for juvenile fish and invertebrates as their nutritional content is beneficial for humans and marine aquaculture species. Recently, they have also been recognized as a promising source for cosmeceutical, nutraceutical, and pharmaceutical products as well as biofuels. Marine microalgae of various species are rich in multiple anti-oxidant phytochemicals and their bioactive components have been employed in cosmetics and dietary supplements. Oil contents in certain groups of marine microalgae are extraordinarily rich and abundant and therefore have been commercialized as omega-3 and omega-6 fatty acid supplements and mass production of microalgaebased biodiesels has been demonstrated by diverse research groups. Numerous natural products from marine microalgae with significant biological activities are reported yearly and this is attributed to their unique adaptive abilities to the great diversity of marine habitats and harsh conditions of marine environments. Previously unknown toxin compounds from red tide-forming dinoflagellates have also been identified which opens up potential applications in the blue biotechnology sector. This review paper provides a brief overview of the biotechnological potentials of Korean marine microalgae. We hope that this review will provide guidance for future marine biotechnology R&D strategies and the various marine microalgae-based industries in Korea.
참고문헌 (199)
- Affan A, "Growth characteristics and antioxidant properties of the benthic diatom Navicula incerta (Bacillariophyceae) from Jeju Island, Korea", J Phycol, 43, pp.823~832 (2007)
- Ariede MB, "Cosmetic attributes of algae: A review", Algal Res, 25, pp.483~487 (2017)
- Arrigo KR, "Marine microorganisms and global nutrient cycles", Nature, 437, pp.349~355 (2005)
- Joana Assunção, "Biotechnological and Pharmacological Applications of Biotoxins and Other Bioactive Molecules from Dinoflagellates", Marine Drugs, 15(12), pp.393~ (2017), MDPI AG[DOI]
- Bae SY, "Activation of murine peritoneal macrophages by sulfated exopolysaccharide from marine microalga Gyrodinium impudicum (strain KG03): Involvement of the NF-κB and JNK pathway", Int Immunopharmacol, 6, pp.473~484 (2006)
- Belay A, "Current knowledge on potential health benefits of Spirulina", J Appl Phycol, 5, pp.235~241 (1993)
- Brinza L, "Marine microand macro-algal species as biosorbents for heavy metals", Environ Eng Manag J, 6, pp.237~251 (2007)
- Brooks G, "Novel microbial food compositions. Korean patent No. 101769121", ~ (2017)
- Camacho FG, "Biotechnological significance of toxic marine dinoflagellates", Biotechnol Adv, 25, pp.176~194 (2007)
- Cancela A, "Harvesting and lipids extraction of Pavlova lutheri", Environ Prog Sustain, 35, pp.1842~1847 (2016)
- Cardozo KH, "Metabolites from algae with economical impact", Comp Biochem Phys C, 146, pp.60~78 (2007)
- Champenois J, "Review of the taxonomic revision of Chlorella and consequences for its food uses in Europe", J Appl Phycol, 27, pp.1845~1851 (2015)
- 조문진, "해양조류 유래 Porphyra-334의 UV 흡수능에 의한피부세포 보호 효과", 한국산학기술학회논문지, 15(7), pp.4272~4278 (2014), 한국산학기술학회[DOI]
- Cho S, "Microalgae cultivation for bioenergy production using wastewaters from a municipal WWTP as nutritional sources", Bioresource Technol, 131, pp.515~520 (2013)
- Cho SH, "Feed composition in the formulated feed for abalone. Korean patent No. 101879776", ~ (2018)
- Cho Y, "Variation of filtration rate of the short-necked clam, Ruditapes philippinarum, with concentration of suspended solid", 석사, pp.2004
- 최강국, "Arthrospira (Spirulina) platensis의 종속영양배양과 r-Linolenic Acid 생산", 한국미생물·생명공학회지, 35(1), pp.45~51 (2007), 한국미생물·생명공학회
- Choi JW, "Inhibitory effect of ethanol extract of Nannochloropsis oceanica on lipopolysaccharide-induced neuroinflammation, oxidative stress, amyloidogenesis and memory impairment", Oncotarget, 8, pp.45517~45530 (2017)
- 최유진, "해수산 클로렐라(Chlorella ellipsoidea) 유기용매 추출물의 항염증 효과", 한국수산과학회지, 43(1), pp.39~45 (2010), 한국수산과학회
- Choi YS, "A method for culturing microalgae by using organic waste resources. Korean patent No. 101061035", ~ (2011)
- Choo M, "The microalgae culture using commercial compound fertilizer", 석사, pp.2014
- Cloern JE, "Phytoplankton primary production in the world’s estuarine-coastal ecosystems", Biogeosciences, 11, pp.2477~2501 (2014)
- Craggs RJ, "Wastewater nutrient removal by marine microalgae grown on a corrugated raceway", Water Res, 31, pp.1701~1707 (1997)
- Corrêa FDN, "Kinetics and equilibrium of lanthanum biosorption by free and immobilized microalgal cells", Adsorp Sci Technol, 35, pp.137~152 (2017)
- Darienko T, "Chloroidium, a common terrestrial coccoid green alga previously assigned to Chlorella (Trebouxiophyceae, Chlorophyta)", Eur J Phycol, 45, pp.79~95 (2010)
- Darienko T, "Genetic variability and taxonomic revision of the genus Auxenochlorella (Shihira et Krauss) Kalina et Puncocharova (Trebouxiophyceae, Chlorophyta)", J Phycol, 51, pp.394~400 (2015)
- Day AG, "Direct chemical modification of microbial biomass and microbial oils. Korean patent No. 101607235", ~ (2016)
- Dolatabadi JEN, "Applications of diatoms and silica nanotechnology in biosensing, drug and gene delivery, and formation of complex metal nanostructures", Trac-Trend Anal Chem, 30, pp.1538~1548 (2011)
- Vinitha Ebenezer, "Toxic effects of Aroclor 1016 and bisphenol A on marine green algae Tetraselmis suecica, diatom Ditylum brightwellii and dinoflagellate Prorocentrum minimum", 미생물학회지, 52(3), pp.306~312 (2016), 한국미생물학회[DOI]
- The state of world fisheries and aquaculture contributing to food security and nutrition for all, "Food and Agriculture Organization of the United Nations", Food and Agriculture Organization of the United Nations, 200~ (2016)
- The state of world fisheries and aquaculture, "Food and Agriculture Organization of the United Nations", Food and Agriculture Organization of the United Nations, 210~ (2018)
- Fukatsu T, "Zooxanthellamide D, a polyhydroxy polyene amide from a marine dinoflagellate, and chemotaxonomic perspective of the Symbiodinium polyols", J Nat Prod, 70, pp.407~411 (2007)
- Go GM, "Method for massive culture of adhesive microalgae. Korean patent No. 101810782", ~ (2017)
- Go GM, "Method of separating silica from adhesive diatoms isolated from Jeju magma sea water and silica separated using the same. Korean patent No. 101788507", ~ (2017)
- Go GM, "Method for red sea cucumber aquaculture using adhesive microalgae. Korean patent No. 101868687", ~ (2018)
- Go S, "Factors affecting the growth and the oil accumulation of marine microalgae, Tetraselmis suecica", Bioproc Biosyst Eng, 35, pp.145~150 (2012)
- Griffiths M, "Algae biotechnology", pp.269~300 (2016), Springer
- Guillerme JB, "Applications for Marine Resources in Cosmetics", Cosmetics, 4(3), pp.35~ (2017), MDPI AG[DOI]
- "AlgaeBase" (2019)[URL]
- Han HK, "Dietary value of benthic diatoms for newly settled abalone, Haliotis discus hannai Ino", Korean Soc Fish Aquat Sci, 13, pp.153~161 (2000)
- Han JJ, "Method for culturing mycoplasma contamination free cells and method for eliminating mycoplasma contamination of cells. Korean patent No. 101620922", ~ (2016)
- Franziska Hempel, "Microalgae as bioreactors for bioplastic production", Microbial Cell Factories, 10(1), pp.81~ (2011), Springer Science and Business Media LLC[DOI]
- Hur SB, "Culture and application of plankton live food in aquaculture", pp.28~ (2015), Life Science Publishing Co
- Hur SB, "Novel Chlorella vulgaris capable low temperature growth and use thereof. Korean patent No. 101323957", ~ (2013)
- Sung Bum Hur, "KMMCC-Korea Marine Microalgae Culture Center: list of strains, 2nd edition", ALGAE, 30, pp.1~188 (2015), 한국조류학회I
- Hur SB, "Feed composition for culturing marine invertebrate larvae. Korean patent No.101871507", ~ (2018)
- Hutchins DA, "Nutrient cycles and marine microbes in a CO2-enriched ocean", Oceanography, 22, pp.128~145 (2009)
- Hwang BS, "Ostreol A: A new cytotoxic compound isolated from the epiphytic dinoflagellate Ostreopsis cf.ovata from the coastal waters of Jeju Island, Korea", Bioorg Med Chem Lett, 23, pp.3023~3027 (2013)
- Hwang BS, "Acuminolide A: structure and bioactivity of a new polyether macrolide from dinoflagellate Dinophysis acuminata", Org Lett, 16, pp.5362~5365 (2014)
- Hwang BS, "Isolation and structure determination of new bioactive compounds originated from marine sponge and toxic dinoflagellate species", 박사, pp.2015
- Hwang BS, "Determination of the absolute configuration of polyhydroxy compound ostreol B isolated from the dinoflagellate Ostreopsis cf. ovata", J Org Chem, 83, pp.194~202 (2018)
- Im SG, "Method for cultivation of microalgae using wastewater pretreated by polymer film. Korean patent No. 101484732", ~ (2015)
- Inoue K, "Recovery of precious metals using microalgae waste", Adv Env Was Mana Rec, 1, pp.1~10 (2018)
- Patent and market analysis report − Application techniques of marine microalgae and microorganisms-derived useful substances, "Intellectual Property On", Intellectual Property On, 57~ (2015)
- International Organization for Standardization, "Water quality-marine algal growth inhibition test with Skeletonema costatum and Phaeodactylum tricornutum", ISO 10253, ~ (1995)
- 장형석, "Description and Application of a Marine Microalga Auxenochlorella protothecoides Isolated from Ulleung-do", 생명과학회지, 27(10), pp.1152~1160 (2017), 한국생명과학회
- Jang SH, "High contents of eicosapentaenoic acid and docosahexaenoic acid in the mixotrophic dinoflagellate Paragymnodinium shiwhaense and identification of putative omega-3 biosynthetic genes", Algal Res, 25, pp.525~537 (2017)
- 전철환, "미세조류 유래 바이오디젤 품질 특성 및 차량 저온 성능평가 연구", 한국수소및신에너지학회논문집, 28(5), pp.545~553 (2017), 한국수소및신에너지학회
- Jeon JY, "Process for preparing feed additives comprising fermented Chlorella and process for preparing feed for breeding chicken using the same. Korean patent No. 101156940", ~ (2012)
- Jeon JY, "Feed additives for producing milk having high amount of milk proteins and process for the preparation of feed for lactating dairy cattle using the same. Korean patent No. 101252132", ~ (2013)
- Jeon JY, "Possibility of heavy metal (Cu and Zn)removal in the contaminated sediments using LED and microalgae", 석사, pp.2016
- Jeon YJ, "Novel antioxidative peptide purified from a marine Chlorella ellipsoidea. Korean patent No. 101440684", ~ (2014)
- Jeon Y, "Antihypersensitive peptide from Chlorella ellipsoidea. Korean patent No. 101404850", ~ (2014)
- Jeong HJ, "Control of the harmful alga Cochlodinium polykrikoides by the naked ciliate Strombidinopsis jeokjo in mesocosm enclosures", Harmful Algae, 7, pp.368~377 (2008)
- Jeong HJ, "Inhibitor comprising dinoflagellates Alexandrium spp. against scuticuciliates. Korean patent No. 101793393", ~ (2017)
- Jeong HJ, "Genetics and morphology characterize the dinoflagellate Symbiodinium voratum, n. sp., (Dinophyceae) as the sole representative of Symbiodinium clade E", J Eukaryot Microbiol, 61, pp.75~94 (2014)
- Jeong HJ, "Reduction in the toxicity caused by a toxic dinoflagellate Gymnodinium catenatum by the feeding of the heterotrophic dinoflagellate Polykrikos kofoidii", Aquat Microb Ecol, 31, pp.307~312 (2003)
- Jeong HJ, "Heterotrophic feeding as a newly identified survival strategy of the dinoflagellate Symbiodinium", P Natl Acad Sci USA, 109, pp.12604~12609 (2012)
- Jeong HJ, "Ecology of Gymnodinium aureolum. I. Feeding in western Korean water", Aquat Microb Ecol, 59, pp.239~255 (2010)
- Jeong HJ, "Feeding by the phototrophic red-tide dinoflagellates: Five species newly revealed and six species previously known to be mixotrophic", Aquat Microb Ecol, 40, pp.133~155 (2005)
- Jha D, "Microalgae-based pharmaceuticals and nutraceuticals: An emerging field with immense market potential", ChemBioEng Rev, 4, pp.257~272 (2017)
- Jiang L, "Biomass and lipid production of marine microalgae using municipal wastewater and high concentration of CO2", Appl Energy, 88, pp.3336~3341 (2011)
- Jo HJ, "The optimum growth conditions and mixotrophy of a toxic benthic dinoflagellate Prorocentrum lima", 석사, pp.2016
- Ju X, "Effective and selective recovery of gold and palladium ions from metal wastewater using a sulfothermophilic red alga, Galdieria sulphuraria", Bioresource Technol, 211, pp.759~764 (2016)
- Jung HJ, "Preparation and characterization of cphycocaynin loaded nanoemulsion systems", 석사, pp.2016
- 정해수, "미세조류 유래 Shinorine의 피부세포에서의 효능", 한국산학기술학회논문지, 15(7), pp.4416~4422 (2014), 한국산학기술학회[DOI]
- 정민화, "6종의 미세조류 추출물의 탈모예방 및 두피 개선 효과 비교", 생명과학회지, 28(3), pp.345~350 (2018), 한국생명과학회[DOI]
- Kalina T, "Taxonomy of the subfamily Scotiellocystoideae Fott 1976 (Chlorellaceae, Chlorophyceae)", Algol Stud, 45, pp.473~521 (1987)
- Kang CH, "Studies on biomass and oil production from eight microalgae using light emitting diode (LED)", 석사, pp.2015
- Kang M, "Comparison of planktonic microalgae growth using LED lights", 석사, pp.2015
- Kang DH, "Method of Spirulina culturing using the medium composition for Spirulina culturing. Korean patent No. 101256434", ~ (2013)
- 강만구, "LED광원을 이용한 해양미세조류의 성장 비교", 수산해양교육연구, 29(2), pp.552~559 (2017), 한국수산해양교육학회
- Kang NS, "Description of a new planktonic mixotrophic dinoflagellate Paragymnodinium shiwhaense n. gen., n. sp. from the coastal waters off western Korea: Morphology, pigments, and ribosomal DNA gene sequence", J Eukaryot Microbiol, 57, pp.121~144 (2010)
- Kang NS, "Morphology and molecular characterization of the epiphytic benthic dinoflagellate Ostreopsis cf. ovata in the temperate waters off Jeju Island, Korea", Harmful Algae, 27, pp.98~112 (2013)
- Kang SH, "Utilization of swine manure for microalgae cultivation", 석사, pp.2016
- Kim B, "Optimization of microalgae (Dunaliella tertiolecta, Tetraselmis chui, Nannochloropsis oculata)culture conditions for biodiesel production", 석사, pp.2012
- Kim MK, "Recent trends in microalgae biotechnology", Bioin Special Webzine, (27), pp.13~ (2012), Biotech Policy Research Center
- Kim J, "Solvent extraction of fucoxanthin from Phaeodactylum tricornutum", Sep Sci Technol, 49, pp.410~415 (2014)
- Kim JS, "Extraction of antifungal substances through the mass culture of Amphidnium carterae", 석사, pp.2014
- Kim HM, "A study on the anti-photoaging effects of Nannochloropsis oceanica extracts and their active component in UVB-irradiated human dermal fibroblasts", 석사, pp.2017
- Kim NK, "Oil production from microalgae and development of persister cell inhibitors", 석사, pp.2013
- Kim BH, "Culture medium of food organisms for diatom. Korean patent No. 101382384", ~ (2014)
- 김동원, "각종 미생물에 의한 음식물쓰레기침출수의 악취저감 연구", 유기물자원화, 13(2), pp.91~97 (2005), 유기성자원학회
- Kim EK, "Increasing γ-linolenic acid content in Spirulina platensis using fatty acid supplement and light-dark illumination", J Appl Phycol, 24, pp.743~750 (2012)
- Kim GY, "Bicarbonatebased cultivation of Dunaliella salina for enhancing carbon utilization efficiency", Bioresource Technol, 237, pp.72~77 (2017)
- 김해미, "해양 미세조류 Amphidinium carterae 추출물의 기능성 평가", Food Science and Preservation, 24(5), pp.673~679 (2017), 한국식품저장유통학회
- Kim HS, "Teleaulax amphioxeia, the cryptophycean strain as a live-feed for mariculture. Korean patent No. 101576838", ~ (2015)
- Kim J, "Pyrogenic transformation of Nannochloropsis oceanica into fatty acid methyl esters without oil extraction for estimating total lipid content", Bioresource Technol, 212, pp.55~61 (2016)
- Kim JH, "Removal of two pathogenic scuticociliates Miamiensis avidus and Miamiensis sp. using cells or culture filtrates of the dinoflagellate Alexandrium andersonii", Harmful Algae, 63, pp.133~145 (2017)
- 김경미, "Characterization of Heterochlorella luteoviridis (Trebouxiaceae, Trebouxiophyceae) isolated from the Port of Jeongja in Ulsan, Korea", 한국해양바이오학회지, 9(2), pp.22~29 (2017), (사)한국해양바이오학회
- Kim KW, "Wound healing composition for skin external application comprising mycosporine-like amino acid and method for preparing the same. Korean patent No. 101833895", ~ (2018)
- Kim M, "Fate of green plastids in Dinophysis caudata following ingestion of the benthic ciliate Mesodinium coatsi:Ultrastructure and psbA gene", Harmful Algae, 43, pp.66~73 (2015)
- Kim MH, "Pharmaceutical composition for prevention or treatment of influenza virus infection comprising sulfated exopolysaccharide as an active ingredient. Korean patent No. 101333785", ~ (2013)
- 김소진, "Interactions between the voracious heterotrophic nanoflagellate Katablepharis japonica and common heterotrophic protists", ALGAE, 32(4), pp.309~324 (2017), 한국조류학회I[DOI]
- Kim SM, "Fucoxanthin fine powder based on beta cyclodextrin and method for manufacturing the same. Korean patent No.101876505", ~ (2018)
- Kim SM, "Chitosan-coated fucoxanthin fine powder based on casein and method for manufacturing the same. Korean patent No. 101875571", ~ (2018)
- Kim SM, "Fucoxanthin fine powder based on casein and method for manufacturing the same. Korean patent No.101876507", ~ (2018)
- Kim SM, "Fucoxanthin fine powder based on whey protein method for manufacturing the same. Korean patent No.101876506", ~ (2018)
- 김윤정, "해양미세조류 에탄올 추출물의 항균활성에 관한 연구", 한국식품과학회지, 49(4), pp.390~395 (2017), 한국식품과학회[DOI]
- Kim ZH, "Algal biomass and biodiesel production by utilizing the nutrients dissolved in seawater using semi-permeable membrane photobioreactors", J Appl Phycol, 27, pp.1763~1773 (2015)
- 김지훈, "Seasonal Assessment of Biomass and Fatty Acid Productivity by Tetraselmis sp. in the Ocean Using Semi-Permeable Membrane Photobioreactors", Journal of Microbiology and Biotechnology, 26(6), pp.1098~1102 (2016), 한국미생물·생명공학회[DOI]
- Knothe G, "Improving biodiesel fuel properties by modifying fatty ester composition", Energ Environ Sci, 2, pp.759~766 (2009)
- 고경준, "염분과 온도의 동시 영향에 따른 해양 미세조류 Nannochloropsis granulata와 Chlorella vulgaris의 중성지질 및 녹말 축적에 관한 연구", 한국해양환경•에너지학회지, 19(3), pp.236~245 (2016), 한국해양환경·에너지학회
- Ko SC, "A novel angiotensin I-converting enzyme (ACE) inhibitory peptide from a marine Chlorella ellipsoidea and its antihypertensive effect in spontaneously hypertensive rats", Process Biochem, 47, pp.2005~2011 (2012)
- Ko SC, "Protective effect of a novel antioxidative peptide purified from a marine Chlorella ellipsoidea protein against free radical-induced oxidative stress", Food Chem Toxicol, 50, pp.2294~2302 (2012)
- A planning research for the development and commercialization of marine bio promising materials, "Korea Institute of Ocean Science and Technology", Korea Institute of Ocean Science and Technology, 89~ (2018)
- Kumar KS, "Microalgae-a promising tool for heavy metal remediation", Ecotox Environ Saf, 113, pp.329~352 (2015)
- Lane CD, "Composition and potential products from Auxenochlorella protothecoides, Chlorella sorokiniana and Chlorella vulgaris", Ind Biotechnol, 13, pp.270~276 (2017)
- Chong-Kyo Lee, "Anti-Picornavirus Activity and Other Antiviral Activity of Sulfated Exopolysaccharide from the Marine Microalga Gyrodinium impudicum Strain KG03", Antiviral Research, 82(2), pp.A40~ (2009), Elsevier BV[DOI]
- Lee CG, "A novel Phaeodactylum tricornutum strain and a method for producing biodiesel using the same. Korean patent No. 101678076", ~ (2016)
- Lee H, "Optimization of variables affecting the direct transesterification of wet biomass from Nannochloropsis oceanica using ionic liquid as a co-solvent", Bioproc Biosyst Eng, 38, pp.981~987 (2015)
- Lee H, "A new method to produce cellulose nanofibrils from microalgae and the measurement of their mechanical strength", Carbohyd Polym, 180, pp.276~285 (2018)
- Lee HK, "Gyrodinium impudicum KG03 strain (KCTC 10325BP) and a method for production of sulfated exopolysaccharide having antiviral effect therefrom. Korean patent No. 100481678", ~ (2005)
- Lee HK, "Immunostimulating composition containing sulfated exopolysaccharide (p-KG03) produced by Gyrodinium impudicum KG03 strain (KCTC 10325BP)therefrom. Korean patent No. 100623460", ~ (2006)
- Lee HS, "Changes in EPA and DHA content of marine microalgae at different environment condition", 석사, pp.2005
- Lee IK, "Algae in Korea: Ecology and application", pp.350~ (2001), Academy Books
- Joon-BaekLee, "Growth Characteristics of Five Microalgal Species Isolated from Jeju Island and Four Microalgal Stock Strains in Hatchery", ALGAE, 17(2), pp.117~125 (2002), 한국조류학회I
- Lee KT, "Feed additive including organic compounds in biofloc and method for production thereof. Korean patent No. 101854016", ~ (2018)
- Lee KT, "Feed stuff for sea cucumber including organic compounds in biofloc and method for preparation thereof. Korean patent No. 101822736", ~ (2018)
- Lee KH, "Mixotrophic ability of the phototrophic dinoflagellates Alexandrium andersonii, A. affine, and A. fraterculus", Harmful Algae, 59, pp.67~81 (2016)
- Lee M, "Characterization of heat shock protein genes from the marine diatom Ditylum brightwellii and their transcriptional responses to environmental stressors", 석사, pp.2014
- Lee M, "Different transcriptional responses of heat shock protein 20 in the marine diatom Ditylum brightwellii exposed to metals and endocrinedisrupting chemicals", Environ Toxicol, 29, pp.1379~1389 (2014)
- 이서이, "수온에 따른 지중해담치 (Mytilus galloprovincialis; Bivalvia) 의 여과율과 섭식율 변동", The Korean Journal of Malacology, 31(3), pp.203~212 (2015), 한국패류학회[DOI]
- 이승홍, "Antioxidant Activity of Solubilized Tetraselmis suecica and Chlorella ellipsoidea by Enzymatic Digests", Preventive Nutrition and Food Science, 14(1), pp.21~28 (2009), 한국식품영양과학회
- Seok-Joo Lee, "Oil Production from Five Marine Microalgae for the Production of Biodiesel", Biotechnology and Bioprocess Engineering, 16(3), pp.561~566 (2011), 한국생물공학회
- 이상범, "A New Diol Ester Derivative of Dinophysistoxin-1 from Cultures of Prorocentrum lima Collected in South Korea", Bulletin of the Korean Chemical Society, 36(1), pp.395~398 (2015), 대한화학회[DOI]
- Lee SH, "The production of high purity phycocyanin by Spirulina platensis using light-emitting diodes based two-stage cultivation", Appl Biochem Biotech, 178, pp.382~395 (2016)
- Lee SY, "The production of high purity phycocyanin from cyanobacterium Spirulina platensis using LEDs based two-stage cultivation. Korean patent No. 101657943", ~ (2016)
- Lee S, "Studies on biomass and oil content of marine microalgae for biodiesel production", 석사, pp.2011
- Lee SB, "Isolation and structure determination of bioactive secondary metabolites from benthic marine dinoflagellates and sponges", 석사, pp.2016
- 이상덕, "Taxonomic study of the genus Achnanthes (Bacillariophyta) in Korean coastal waters", Journal of Ecology and Environment, 36(4), pp.391~406 (2013), 한국생태학회[DOI]
- Lee SM, "Investigation of cultivation and FAME composition isolated Phaeodactylum tricornutum from Youngheung island", J Mar Biosci Biotechnol, 6, pp.47~52 (2014)
- Lim KH, "Variation of filtration rate of the shortnecked clam, Ruditapes philippinarum, Adams and Reeve with temperature and salinity", 석사, pp.2002
- 임경훈, "말백합의 연령별 여과율에 미치는 수온과 염분의 영향", The Korean Journal of Malacology, 24(3), pp.175~187 (2008), 한국패류학회
- Matsunaga T, "Screening of marine microalgae for bioremediation of cadmium-polluted seawater", J Biotechnol, 70, pp.33~38 (1999)
- 민병희, "미세조류의 종류와 농도에 따른 기수산 cyclopoid 요각류 Paracyclopina nana의 초식", 한국양식학회지, 19(4), pp.310~314 (2006), 한국양식학회
- Mass culture of microalgae and application for the development of early aquaculture feed and extraction of high value products, "Ministry of Future Creation and Science", Ministry of Future Creation and Science, 36~ (2015)
- "1st administrative master plan for marine bioresources" (2019)[URL]
- Ana F. Miranda, "Applications of microalgal biofilms for wastewater treatment and bioenergy production", Biotechnology for Biofuels, 10(1), pp.120~ (2017), Springer Science and Business Media LLC[DOI]
- Meerambika Mishra, "All New Faces of Diatoms: Potential Source of Nanomaterials and Beyond", Frontiers in Microbiology, 8, pp.1239~ (2017), Frontiers Media SA[DOI]
- Moh SH, "Anti-UV composition for skin external application comprising peptide derivatives from extract of microalgae comprising the same. Korean patent No. 101552010", ~ (2015)
- 모상현, "미세조류 추출물 및 MAAs 함유 자외선차단제의 자외선차단지수(SPF) 및 자외선 A 차단지수(PFA) 평가", 한국산학기술학회논문지, 15(5), pp.3312~3318 (2014), 한국산학기술학회[DOI]
- Moore JK, "Iron cycling and nutrient limitation patterns in surface waters of the world ocean", Deep-Sea Res Pt II, 49, pp.463~508 (2001)
- Monteiro CM, "Metal uptake by microalgae:underlying mechanisms and practical applications", Biotechnol Progr, 28, pp.299~311 (2012)
- Neustupa J, "Kalinella bambusicola gen. et sp. nov. (Trebouxiophyceae, Chlorophyta), a novel coccoid Chlorella-like subaerial alga from Southeast Asia", Phycol Res, 57, pp.159~169 (2009)
- 오석진, "미세조류 4종(Chlorella vulgaris, Nitzschia sp., Phaeodactylum tricornutum, Skeletonema sp.)의 성장에 미치는 발광다이오드 단일파장의 영향", 해양환경안전학회지, 21(1), pp.1~8 (2015), 해양환경안전학회[DOI]
- Onodera KI, "Zooxanthellamide Cs: Vasoconstrictive polyhydroxylated macrolides with the largest lactone ring size from a marine dinoflagellate of Symbiodinium sp", J Am Chem Soc, 127, pp.10406~10411 (2005)
- Onodera KI, "Zooxanthellamide B, a novel large polyhydroxy metabolite from a marine dinoflagellate of Symbiodinium sp", Biosci Biotech Bioch, 68, pp.955~958 (2004)
- Paniagua-Michel J, "Handbook of marine microalgae", pp.255~267 (2015), Academic Press
- Park HW, "The selection of the cryptophyte Teleaulax amphioxeia strains for a prey organism of rotifer and bivalve larvae", 석사, pp.2012
- 박희원, "은편모류 Teleaulax amphioxeia의 윤충류 Brachionus plicatilus 및 이매패류 유생 2종에 대한 먹이 기능성 평가", 한국수산과학회지, 49(3), pp.351~358 (2016), 한국수산과학회
- 박지연, "Nannochloropsis oceanica로부터 용매추출법을 이용한 미세조류 오일 회수", Korean Chemical Engineering Research(HWAHAK KONGHAK), 52(1), pp.88~91 (2014), 한국화학공학회[DOI]
- Park JG, "Comparison of morphological characteristics and the 24S rRNA sequences of Cochlodinium polykrikoides and Gyrodinium impudicum", J Kor Soc Oce, 4, pp.363~370 (1999)
- Park MG, "First successful culture of the marine dinoflagellate Dinophysis acuminata", Aquat Microb Ecol, 45, pp.101~106 (2006)
- Park TG, "Economic impact, management and mitigation of red tides in Korea", Harmful Algae, 30, pp.S131~S143 (2013)
- Alok Patel, "Heterotrophic cultivation of Auxenochlorella protothecoides using forest biomass as a feedstock for sustainable biodiesel production", Biotechnology for Biofuels, 11(1), pp.169~ (2018), Springer Science and Business Media LLC[DOI]
- Piechocki J, "Lipid-rich microalgal flour food compositions. Korean patent No. 101849367", ~ (2018)
- Polle, Jurgen E. W., "Identification and Characterization of a New Strain of the Unicellular GreenAlga Dunaliella salina (Teod.) from Korea", Journal of Microbiology and Biotechnology, 18(5), pp.821~827 (2008), 한국미생물·생명공학회
- Ra CH, "Cultivation of four microalgae for biomass and oil production using a two-stage culture strategy with salt stress", Renew Energ, 80, pp.117~122 (2015)
- Ra C, "Effects of light-emitting diodes (LEDs) on the accumulation of lipid content using a two-phase culture process with three microalgae", Bioresource Technol, 212, pp.254~261 (2016)
- Rawat I, "Algae biotechnology", pp.249~268 (2016), Springer
- Rho JR, "Acuminolide A from Dinophysis acuminata and Method for isolating the same and composition for preventing or treating muscle weakness diseases comprising the same. Korean patent No. 101656285", ~ (2016)
- Ryu BM, "Handbook of marine microalgae", pp.309~316 (2015), Academic Press
- Ryu HS, "Study of the salinity acclimation in Dunaliella", 석사, pp.2011
- Satake M, "Structures of the largest amphidinol homologues from the dinoflagellate Amphidinium carterae and structure-activity relationships", J Nat Prod, 80, pp.2883~2888 (2017)
- Seong KA, "Bacterivory by co-occurring red-tide algae, heterotrophic nanoflagellates, and ciliates on marine bacteria", Mar Ecol-Prog Ser, 322, pp.85~97 (2006)
- Shah MMR, "Potentiality of benthic dinoflagellate cultures and screening of their bioactivities in Jeju Island, Korea", Afr J Biotechnol, 13, pp.792~805 (2014)
- Shah MMR, "Growth characteristics of three benthic dinoflagellates in mass culture and their antioxidant properties", J Fish Aquat Sci, 11, pp.268~277 (2016)
- Shen N, "Selective biosorption of precious metals by cell-surface engineered microalgae", Chem Engineer Trans, 61, pp.25~30 (2017)
- Shim C, "Screening of microalgae for biodiesel and optimal culture condition", 석사, pp.2010
- Slade R, "Micro-algae cultivation for biofuels:cost, energy balance, environmental impacts and future prospects", Biomass Bioenerg, 53, pp.29~38 (2013)
- Spolaore P, "Commercial applications of microalgae", J Biosci Bioeng, 101, pp.87~96 (2006)
- Suh SS, "Anti-inflammation activities of mycosporine-like amino acids (MAAs) in response to UV radiation suggest potential anti-skin aging activity", Mar Drugs, 12, pp.5174~5187 (2014)
- Tang D, "Spatial, seasonal and species variations of harmful algal blooms in the South Yellow Sea and East China Sea", Hydrobiologia, 568, pp.245~253 (2006)
- Trimbur DE, "Production of oil in microorganisms. Korean patent No. 101523255", ~ (2015)
- Venkatesan J, "Handbook of marine microalgae", pp.1~9 (2015), Academic Press
- Wang J, "Biosorbents for heavy metals removal and their future", Biotechnol Adv, 27, pp.195~226 (2009)
- Whitton R, "Microalgae for municipal wastewater nutrient remediation: Mechanisms, reactors and outlook for tertiary treatment", Environ Technol Rev, 4, pp.133~148 (2015)
- "World register of marine species" (2019)[URL]
- Yang AR, "Limaol: A Polyketide from the benthic marine dinoflagellate Prorocentrum lima", J Nat Prod, 80, pp.1688~1692 (2017)
- Yang AR, "Isolation and structure determination of bioactive compounds from two marine dinoflagellates", 석사, pp.2017
- Yih W, "Methods for massive culture of Dinophysis acuminata and isolation of pectenotoxin-2. Korean patent No. 101055594", ~ (2011)
- Yim JH, "A study on the characterization and production of exopolysaccharide produced by marine microalgae Gyrodinium impudicum strain KG03", 박사, pp.2002
- Yim JH, "Optimal conditions for the production of sulfated polysaccharide by marine microalga Gyrodinium impudicum strain KG03", Biomol Eng, 20, pp.273~280 (2003)
- Joung Han Yim, "Axenic Culture of Gyrodinium impudicum Strain KG03, a Marine Red-tide Microalga that Produces Exopolysaccharide", The Journal of Microbiology, 42(4), pp.305~314 (2004), 한국미생물학회
- Yim JH, "Antiviral effects of sulfated exopolysaccharide from the marine microalga Gyrodinium impudicum strain KG03", Mar Biotechnol, 6, pp.17~25 (2004)
- Yim JH, "Novel sulfated polysaccharide derived from red-tide microalga Gyrodinium impudicum strain KG03 with immunostimulating activity in vivo", Mar Biotechnol, 7, pp.331~338 (2005)
- Yoo YD, "Feeding by the newly described mixotrophic dinoflagellate Paragymnodinium shiwhaense:feeding mechanism, prey species, and effect of prey concentration", J Eukaryot Microbiol, 57, pp.145~158 (2010)
- Eun Yoon, "Characterization of a New Trioxilin and a Sulfoquinovosyl Diacylglycerol with Anti-Inflammatory Properties from the Dinoflagellate Oxyrrhis marina", Marine Drugs, 15(3), pp.57~ (2017), MDPI AG[DOI]
