Epidermal Skin Barrier
2
조회
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다운로드
9
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0
참고문헌
키워드
초록
Stratum corneum made from cell division and differentiation of epidermal keratinocytes has been identified as a core tissue in the skin barrier. In the stratum corneum formation stage, abnormality and imbalances at each step cause functional disorder of skin barrier. In order to better understand the factors that regulate functions of the stratum corneum, this paper described the components of the skin barrier in detail. From the description of “Brick & Mortar”, the major components of the skin barrier such as lamellar bodies (LB), cornified cell envelope (CE), lipid, calcium, cytokine and moisturizer were described in detail. Two types of granules are formed epidermal keratinocyte on the stratum granulosum, including keratohyalin granule filled with protein and lamellar bodies filled with lipid, and keratin protein membrane and keratin lipid membrane together are called CE which forms the boundary of epidermal keratinocyte. Filaggrin acts as an adhesive to adhere keratin together, and is also involved in the binding of protein-forming CE. Skin lipids play an important role with their barrier function, and can also bring various effects on the skin as signaling molecules in addition to supporting its defense mechanism such as antibacterial function. Calcium is involved in the structure-retention of LB and secretion of LB to intercellular spaces, and calcium gradient plays an important role in the formation of a skin barrier. When the skin barrier is damaged, substances called cytokines such as tumor necrosis factor (TNF), interleukin 1 (IL1) and interleukin 6 (IL6), are secreted. However, if the barrier damage persists and these cytokines increase chronically, it may cause an adverse result such as inflammation or cuticularization. The concept of moisturizer in the past was understood as the replenishment of moisture to skin, but recently attention has been focused on the restoration of the barrier function, which is the most important function of skin, rather than the simple replenishment of moisture. Currently, physiologic lipid mixture can be considered as the most ideal moisturizer.
Abstract
Stratum corneum made from cell division and differentiation of epidermal keratinocytes has been identified as a core tissue in the skin barrier. In the stratum corneum formation stage, abnormality and imbalances at each step cause functional disorder of skin barrier. In order to better understand the factors that regulate functions of the stratum corneum, this paper described the components of the skin barrier in detail. From the description of “Brick & Mortar”, the major components of the skin barrier such as lamellar bodies (LB), cornified cell envelope (CE), lipid, calcium, cytokine and moisturizer were described in detail. Two types of granules are formed epidermal keratinocyte on the stratum granulosum, including keratohyalin granule filled with protein and lamellar bodies filled with lipid, and keratin protein membrane and keratin lipid membrane together are called CE which forms the boundary of epidermal keratinocyte. Filaggrin acts as an adhesive to adhere keratin together, and is also involved in the binding of protein-forming CE. Skin lipids play an important role with their barrier function, and can also bring various effects on the skin as signaling molecules in addition to supporting its defense mechanism such as antibacterial function. Calcium is involved in the structure-retention of LB and secretion of LB to intercellular spaces, and calcium gradient plays an important role in the formation of a skin barrier. When the skin barrier is damaged, substances called cytokines such as tumor necrosis factor (TNF), interleukin 1 (IL1) and interleukin 6 (IL6), are secreted. However, if the barrier damage persists and these cytokines increase chronically, it may cause an adverse result such as inflammation or cuticularization. The concept of moisturizer in the past was understood as the replenishment of moisture to skin, but recently attention has been focused on the restoration of the barrier function, which is the most important function of skin, rather than the simple replenishment of moisture. Currently, physiologic lipid mixture can be considered as the most ideal moisturizer.
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