Importance of Stratum Corneum Acidification to Restore Skin Barrier Function in Eczematous Diseases
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Skin barrier function relies on three essential components: stratum corneum (SC) lipids, natural moisturizing factors (NMFs), and the acidic pH of the SC surface. Three endogenous pathways contribute to acidity: free fatty acids from phospholipids, trans-urocanic acid from filaggrin (FLG), and the sodium-proton antiporter (NHE1) activity. An acidic SC environment boosts the activity of enzymes to produce ceramides, which are vital for skin health. Conversely, an elevated pH can lead to increased skin infections, reduced lipid-processing enzyme activity, impaired permeability barrier recover y, and compromised integrity and cohesion of the SC due to increased serine protease (SP) activity. Elevated SC pH is obser ved in neonatal, aged, and inflamed skin. In atopic dermatitis (AD), it results from decreased NMF due to reduced FLG degradation, decreased fatty acids from reduced lamellar body secretion, and reduced lactic acid due to decreased sweating. Moreover, the imbalance between SP and SP inhibitors disrupts barrier homeostasis. However, acidif ying the SC can help restore balance and reduce SP activity. Acidic water bathing has been found to be safe and effective for AD. In three different AD murine models, SC acidification prevented the progression of AD to respirator y allergies. In aging skin, a decrease in NHE1 leads to an increased skin pH. Mild acidic skin care products or moisturizers containing NHE1 activators can normalize skin pH and improve barrier function. In conclusion, maintaining the acidity of the SC is crucial for healthy skin barrier function, leading to significant benefits for various skin conditions, such as AD and aging-related skin issues.
Abstract
Skin barrier function relies on three essential components: stratum corneum (SC) lipids, natural moisturizing factors (NMFs), and the acidic pH of the SC surface. Three endogenous pathways contribute to acidity: free fatty acids from phospholipids, trans-urocanic acid from filaggrin (FLG), and the sodium-proton antiporter (NHE1) activity. An acidic SC environment boosts the activity of enzymes to produce ceramides, which are vital for skin health. Conversely, an elevated pH can lead to increased skin infections, reduced lipid-processing enzyme activity, impaired permeability barrier recover y, and compromised integrity and cohesion of the SC due to increased serine protease (SP) activity. Elevated SC pH is obser ved in neonatal, aged, and inflamed skin. In atopic dermatitis (AD), it results from decreased NMF due to reduced FLG degradation, decreased fatty acids from reduced lamellar body secretion, and reduced lactic acid due to decreased sweating. Moreover, the imbalance between SP and SP inhibitors disrupts barrier homeostasis. However, acidif ying the SC can help restore balance and reduce SP activity. Acidic water bathing has been found to be safe and effective for AD. In three different AD murine models, SC acidification prevented the progression of AD to respirator y allergies. In aging skin, a decrease in NHE1 leads to an increased skin pH. Mild acidic skin care products or moisturizers containing NHE1 activators can normalize skin pH and improve barrier function. In conclusion, maintaining the acidity of the SC is crucial for healthy skin barrier function, leading to significant benefits for various skin conditions, such as AD and aging-related skin issues.
참고문헌 (53)
- Yuki T, "Impaired tight junctions obstruct stratum corneum formation by altering polar lipid and profilaggrin processing", J Dermatol Sci, 69, pp.148~158 (2013)
- Choi EH, "Aging of the skin barrier", Clin Dermatol, 37, pp.336~345 (2019)
- Weerheim A, "Determination of stratum corneum lipid profile by tape stripping in combination with high-performance thin-layer chromatography", Arch Dermatol Res, 293, pp.191~199 (2001)
- Grubauer G, "Transepidermal water loss : the signal for recovery of barrier structure and function", J Lipid Res, 30, pp.323~333 (1989)
- White-Chu EF, "Dry skin in the elderly : complexities of a common problem", Clin Dermatol, 29, pp.37~42 (2011)
- Lodén M, "Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders", Am J Clin Dermatol, 4, pp.771~788 (2003)
- Ali SM, "Skin pH : from basic science to basic skin care", Acta Derm Venereol, 93, pp.261~267 (2013)
- Lambers H, "Natural skin surface pH is on average below 5, which is beneficial for its resident flora", Int J Cosmet Sci, 28, pp.359~370 (2006)
- Percival SL, "The effects of pH on wound healing, biofilms, and antimicrobial efficacy", Wound Repair Regen, 22, pp.174~186 (2014)
- Hachem JP, "pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity", cohesion, 2003, pp.121, 345~353
- Harding CR, "The stratum corneum : structure and function in health and disease", Dermatol Ther, 17(Suppl 1), pp.6~15 (2004)
- Rosso JD, "Understanding the epi¬dermal barrier in healthy and compromised skin : clinically relevant infor¬mation for the dermatology practitioner : proceedings of an expert panel roundtable meeting", J Clin Aesthet Dermatol, 9, pp.S2~S8 (2016)
- Harding CR, "Dry skin, moisturization and corneodesmolysis", Int J Cosmet Sci, 22, pp.21~52 (2000)
- Farage MA, "Intrinsic and extrinsic factors affecting skin surface pH", Curr Probl Dermatol, 54, pp.33~47 (2018)
- Gethin G, "The significance of surface pH in chronic wounds", Wounds UK, 3, pp.52~56 (2007)
- Lukić M, "Towards optimal pH of the skin and topical formulations : from the current state of the art to tailored products", Cosmetics, 8, pp.69~ (2021)
- Yosipovitch G, "Time-dependent variations of the skin barrier function in humans : transepidermal water loss, stratum corneum hydration, skin surface pH, and skin temperature", J Invest Dermatol, 110, pp.20~23 (1998)
- Behne MJ, "Neonatal development of the stratum corneum pH gradient : localization and mechanisms leading to emergence of optimal barrier function", J Invest Dermatol, 120, pp.998~1006 (2003)
- Fluhr JW, "Stratum corneum pH : formation and function of the ‘acid mantle’", Exogenous Dermatol, 1, pp.163~175 (2002)
- Mauro T, "Skin barrier", pp.223~230 (2006), Taylor & Francis
- Choi EH, "Stratum corneum acidification is impaired in moderately aged human and murine skin", J Invest Dermatol, 127, pp.2847~2856 (2007)
- Xu W, "Hydration status regulates sodium flux and inflammatory pathways through epithelial sodium channel(ENaC)in the skin", J Invest Dermatol, 135, pp.796~806 (2015)
- Fluhr JW, "Stratum corneum acidification in neonatal skin : secretory phospholipase A2 and the sodium", hydrogen antiporter-1 acidify neonatal rat stratum corneum, 2004, pp.122, 320~329
- Hart PH, "The multiple roles of urocanic acid in health and disease", J Invest Dermatol, 141, pp.496~502 (2021)
- Zlotogorski A, "Distribution of skin surface pH on the forehead and cheek of adults", Arch Dermatol Res, 279, pp.398~401 (1987)
- Öhman H, "The pH gradient over the stratum corneum differs in X-linked recessive and autosomal dominant ichthyosis : a clue to the molecular origin of the"acid skin mantle"", J Invest Dermatol, 111, pp.674~677 (1998)
- Elias PM, "Stratum corneum acidification : how and why?", Exp Dermatol, 24, pp.179~180 (2015)
- Holleran WM, "β-glucocerebrosidase activity in murine epidermis : characterization and localization in relation to differentiation", J Lipid Res, 33, pp.1201~1209 (1992)
- Schommer NN, "Structure and function of the human skin microbiome", Trends Microbiol, 21, pp.660~668 (2013)
- Hachem JP, "Acute acidification of stratum corneum membrane domains using polyhydroxyl acids improves lipid processing and inhibits degradation of corneodesmosomes", J Invest Dermatol, 130, pp.500~510 (2010)
- Miajlovic H, "Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus", J Allergy Clin Immunol, 126, pp.1184~1190 (2010)
- Kamisango K, "Structures and biological activities of peptidoglycans of Listeria monocytogenes and Propionibacterium acnes", J Biochem, 92, pp.23~33 (1982)
- Leung DY, "New insights into atopic dermatitis : role of skin barrier and immune dysregulation", Allergol Int, 62, pp.151~161 (2013)
- Kong HH, "Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis", Genome Res, 22, pp.850~859 (2012)
- Seidenari S, "Baseline biophysical parameters in subjects with sensitive skin", Contact Dermat, 38, pp.311~315 (1998)
- Adam R, "Skin care of the diaper area", Pediatr Dermatol, 25, pp.427~433 (2008)
- Dharmage SC, "Atopic dermatitis and the atopic march revisited", Allergy, 69, pp.17~27 (2014)
- Lowe AJ, "The skin as a target for prevention of the atopic march", Ann Allergy Asthma Immunol, 120, pp.145~151 (2018)
- Jung M, "Pyrrolidone carboxylic acid levels or caspase-14 expression in the corneocytes of lesional skin correlates with clinical severity, skin barrier function and lesional inflammation in atopic dermatitis", J Dermatol Sci, 76, pp.231~239 (2014)
- Rippke F, "Stratum corneum pH in atopic dermatitis : impact on skin barrier function and colonization with Staphylococcus aureus", Am J Clin Dermatol, 5, pp.217~223 (2004)
- Elias PM, "Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis", J Allergy Clin Immunol, 134, pp.781~791 (2014)
- Choi EH, "Pathogenesis of atopic dermatitis", J Korean Med Assoc, 57, pp.218~225 (2014)
- Kubota K, "Treatment of refractory cases of atopic dermatitis with acidic hot-spring bathing", Acta Derm Venereol, 77, pp.452~454 (1997)
- Sasai-Takedatsu M, "Reduction of Staphylococcus aureus in atopic skin lesions with acid electrolytic water--a new therapeutic strategy for atopic dermatitis", Allergy, 52, pp.1012~1016 (1997)
- Hatano Y, "Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis", J Invest Dermatol, 129, pp.1824~1835 (2009)
- Lee NR, "Application of topical acids improves atopic dermatitis in murine model by enhancement of skin barrier functions regardless of the origin of acids", Ann Dermatol, 28, pp.690~696 (2016)
- Lee NR, "Acidic water bathing could be a safe and effective therapeutic modality for severe and refractory atopic dermatitis", Ann Dermatol, 28, pp.126~129 (2016)
- Lee HJ, "Topical acidic cream prevents the development of atopic dermatitis-and asthma-like lesions in murine model", Exp Dermatol, 23, pp.736~741 (2014)
- Lee HJ, "Atopic march from atopic dermatitis to asthma-like lesions in NC", Nga mice is accelerated or aggravated by neutralization of stratum corneum but partially inhibited by acidification, 2015, pp.135, 3025~3033
- Lee HJ, "Acidification of stratum corneum prevents the progression from atopic dermatitis to respiratory allergy", Exp Dermatol, 26, pp.66~72 (2017)
- Jürgen B, "Treatment of aged skin with a pH 4 skin care product normalizes increased skin surface pH and improves barrier function : results of a pilot study", J Cosmet Dermatol Sci Appl, 1, pp.50~58 (2011)
- Kilic A, "Skin acidification with a water-in-oil emulsion(pH 4)restores disrupted epidermal barrier and improves structure of lipid lamellae in the elderly", J Dermatol, 46, pp.457~465 (2019)
- Jung SW, "Rosmarinic acid, as an NHE1 activator, decreases skin surface pH and improves the skin barrier function", Int J Mol Sci, 23, pp.3910~ (2022)
