실버 알지네이트의 Propionibacterium acnes에 대한 항균효과 연구
A Study on Antimicrobial Effects of Silver-Alginate on Propionibacterium acnes
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This study conducted low-molecularization of alginate to maximize antimicrobial effects and examined antimicrobial effects silver-alginate which substituted Ag+ for silver(Ag, organic antimicrobial) on Propionibacterium acnes. Antimicrobial effects of silver-alginate which was substituted by Ag+ in low-molecular alginate on P. acnes was identified by MIC. As a result, it was found that low-molecular alginate(MIC = 10,000 ㎍/㎖) and silver-alginate(MIC = 200 ㎍/㎖) had more excellent antimicrobial than lavender oil and tea tree oil which are well known for excellent antimicrobial(MIC = 20,000 ㎍/㎖). Concentration according to culture time of P. acnes was examined. As a result, concentration of silver-alginate was 0.10, 0.15, 0.21, 0.31, 0.48, and 1.01 by culture time. It indicates that it significantly inhibited the growth of P. acnes compared with the control group. Also, MIC and concentration according to culture time was measured in P. acne of alginate paste made of silver-alginate solution, and antimicrobial persistence was confirmed. acnes concentration, suggesting more excellent antimicrobial and persistent antimicrobial.
Abstract
This study conducted low-molecularization of alginate to maximize antimicrobial effects and examined antimicrobial effects silver-alginate which substituted Ag+ for silver(Ag, organic antimicrobial) on Propionibacterium acnes. Antimicrobial effects of silver-alginate which was substituted by Ag+ in low-molecular alginate on P. acnes was identified by MIC. As a result, it was found that low-molecular alginate(MIC = 10,000 ㎍/㎖) and silver-alginate(MIC = 200 ㎍/㎖) had more excellent antimicrobial than lavender oil and tea tree oil which are well known for excellent antimicrobial(MIC = 20,000 ㎍/㎖). Concentration according to culture time of P. acnes was examined. As a result, concentration of silver-alginate was 0.10, 0.15, 0.21, 0.31, 0.48, and 1.01 by culture time. It indicates that it significantly inhibited the growth of P. acnes compared with the control group. Also, MIC and concentration according to culture time was measured in P. acne of alginate paste made of silver-alginate solution, and antimicrobial persistence was confirmed. acnes concentration, suggesting more excellent antimicrobial and persistent antimicrobial.
참고문헌 (15)
- 김영재, "Nano-silver를 이용한 다양한 식물 병원성 곰팡이에 대한 방제 효과", 석사, pp.2009
- 이홍금, "해양으로부터 기능성 화장품 소재 개발동향. 보건산업 기술동향", ~ (2001)
- 이철재, "은나노 입자가 첨착된 활성탄의 항균특성에 관한 연구", 공업화학, 18(4), pp.396~399 (2007), 한국공업화학회
- 이학성, "알긴산염을 이용한 항균제의 제조 및 항균효과", KSBB Journal, 17(1), pp.63~67 (2002), 한국생물공학회
- 조민, "감마선과 유기산을 이용한 알긴산 용액의 저분화에 대한 연구" (2003), 경희대학교 식품공학과, 목포대학교 식품생물공학과
- 황재관, "리그난계 화합물을 유효성분으로 함유하는 여드름 치료 또는 예방용 조성물. 특허 10-0567431", ~ (2006)
- Beele H, "A prospective randomised open label study to evaluate the potential of anesilver alginate", carboxymethyl cellulose antimicrobial wond dessing to promote wound healing, 2004, pp.7(4), 262~227
- Colwell, R. R, E. R, "Biotechnology of Marine Polysaccharides" (1985), Hemisphere PublishingCo
- De Pailippis, R. M, "Vincenzni, ysaccharides from cyanobacteria and tyir possible applications", FEMS Microbiol. Rev (1998)
- Kearney J. K, "The Follicular distributation and abundance of resistent bacteriaon human skin", J Gen Microbiol, 130, pp.797~801 (1994)
- Leeming J. P., "The microbial ecology of pilosebaceous units from human skin", J Gen Microbiol, 130, pp.803~807 (1984)
- Opasanon S, "Clinical effectiveness of alginate silver dressing in outpatient management of partical-thickness burns", Int Wound J, 7(6), pp.467~471 (2010)
- Puhvel S. M, "Reevaluation of fatty acids as inflammatory agents in acne", J Inusest Dermatol, 68(2), pp.93~97 (1997)
- R. I. Davise, , Catalysil Today, 35, pp.87~ (1997)
- S. Silver, , FEMS Microbiology Reviews, 27, pp.341~ (2003)