에센셜 오일 배합물의 Propionibacterium acnes에 대한 항균활성
Antibacterial Activity of Essential Oil Blends Against Propionibacterium acnes
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초록
여드름 원인균인 Propionibacterium acnes을 대상으로 15종 에센셜 오일의 1 : 1 배합물의 항균효과를 디스크 확산법으로 측정한 결과, 105종의 조합 중 57가지는 저지원의 직경이 증가하 여 균 억제에 효과적이었다. 이 중 팔마로사와 로즈마리의 조합 이 가장 높은 저지원 증가율 (105.7%)을 보여 가장 효과적인 것 으로 나타났다. 반면 47가지는 저지원의 직경이 감소하여 효과 적이지 않았다. 이중 페퍼민트-그레이프푸룻 및 페퍼민트-레몬 은 저지원 직경이 각각 63.5% 및 57.4%로 가장 크게 감소하였 다. Checkerboard 희석법으로 FBCI를 측정한 결과 팔마로사- 로즈마리 조합은 부분적 상승작용으로, 페퍼민트-그레이프푸룻 및 페퍼민트-레몬은 저해작용으로 나타났고, 다른 조합들은 첨 가작용이거나 상호작용이 없을 것이라 예상되었다. 본 연구 결 과를 바탕으로 하여 여드름 관리 시 에센셜 오일 블렌딩의 효 능을 규명하기 위한 추가적인 연구가 필요하다고 사료된다.
Abstract
In this study, the in vitro activity of 105 combinations of 15 essential oils against Propionibacterium acnes was assessed, with the aim of identifying essential oil blends that might exhibit synergistic or antagonistic effects. These 15 essential oils were chosen because they are used in aromatherapy for the treatment of acne. The mixtures of the essential oils at ratio of 1 : 1 were tested. In the disk diffusion test, the diameters of the inhibition zone increased for 57 combinations and decreased for 47 combinations when compared with the mean values of the inhibition zone diameters for individual oils. The diameter of the inhibition zone was not changed for the other one combination (grapefruit- bergamot). The highest enhancing effect was detected for the palmarosa-rosemary combination (inhibition zone diameter increased by 105.7%). The highest levels of reduction of the inhibitory activity were seen in the peppermint-grapefruit and peppermint-lemon combinations (inhibition zone diameters decreased by 63.5% and 57.4%, respectively). In the checkerboard dilution test, the palmarosa-rosemary combination showed a partial synergistic effect, whereas the peppermint-grapefruit and peppermint-lemon combinations showed antagonisms. These data indicate variable degrees of interaction between antibacterial activities of essential oil blends against P. acnes.
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