감나무 잎 추출물, 율피 추출물, 호장근 추출물을 함유한 화장료의 안전성 및 인체효능평가 연구

Abstract

Skin lipids play a role as barrier function to control moisture loss to prevent dry skin and protect from external harmfulsubstances or bacteria in order for providing sterilization. However, when there is excessive secretion of sebum due toabnormal action of hormones, it will cause black heads and expansion of the pores so that waste will be accumulated. Nose pack is an easy way to clean pores around nose with sebaceous glands, but due to characteristics of the fabric,the existing products can cause irritation and corneous. Thus, this study is to develop cosmetics for sebum removaland pore improvement that can improve limitations of the existing products. The ingredients for the formulationsinclude Diospyros kaki (D. kaki ), Castanea crenata (C. crenata ), and Polygonum cuspidatum (P. cuspidatum) and toverify the safety and human efficacy evaluation. Based on the guidelines stated on ministry of food and drug safety,bacteria microbial limit test for 5 kinds of microorganisms, and human patch test with 31 men and women who donot have any skin diseases and skin hypersensitivity were executed. Also, with 23 men and women who have oilyskin, human efficacy evaluation was performed. For control group, changes in the amount of sebum, moisture, deadskin condition, blackhead, skin roughness between before and after the test were compared. As a result of safetyassessment, for microbial limit test, there was no aerobic bacteria, Staphylococcus aureus, Pseudomonas aerusinosa,Escherichia coli, yeast and fungi, and for human patch test, there was no skin reactions such as redness, blisters orallergic. For changes in the amount of sebum and black head from human efficacy evaluation, there were temporaryimprovement for the experimental group. For the amount of moisutre, dead skin, and skin roughness, the experimenta lgroup showed improvement. This is expected to be used not only in deep cleanser, but also in lotion, emulsion,soap and foam cleanser and have the same effects. And for additional research on the treatment of acne and topicalpharmaceutical formula, it can be utilized. And when being complemented with body application test for long-termusage, they can be used as natural ingredients when cosmetic manufacturers or sellers are developing new products,and also can be supplied as informative material to induce scientific and objective ads and displays properly.