베트남 등 산지별 침향의 휘발성 성분 분석 연구
A Comparative Analysis of the Volatile Components of Agarwood from Vietnam and other Regions
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목적: 이 연구의 목적은 베트남산 침향과 인근 4개 국가에서 생산된 침향을 GC-MS로 휘발성 성분 분석을 통해 피부 건강과 관련한 효능이 보고된 성분을 확인하고, 향후 천연 화장품 원료로 활용 가능성을 확인하고자 하였다. 방법: 베트남산 Aquilaria crassna (A. crassna) 침향을 포함하여 인도네시아, 말레이시아, 미얀마, 캄보디아 각각 침향을 포함하여 총 5개의 침향 시료를 확보하였고, 각각 침향에 대하여 시료 1-5로 명명하고 GC-MS로 측정하여 정성분석 결과를 비교하였다. 베트남산 침향(시료 1)은 DNA 분석을 통해 A. crassna 임을 동정하고 표준품으로 선정하였다. 결과: GC-MS 실험 결과 침향의 휘발성 성분 중sesquiterpene을 주로 포함하고 있었다. 시료 1-5 공통으로 검출되는 성분은 sesquiterpene으로 italicene ether, epi-γ-eudesmol, δ-guaiene, α-agarofuran의 4종이었고, 단순 휘발성 방향성 성분(simple volatile aromatic compounds, SVAC)으로 1-octanol, 4-(4-methoxyphenyl)-2-butanone, 4-phenyl-2-butanone, benzaldehyde, ethylbenzene, nonanal, octanal, 2-ethyl-1- hexanol 등 8종이었다. 특히 sesquiterpene 성분 중 α-agarofuran, β-selinene, α-curcumene, α-santalol 등은 각각 항염증, 항산화, 항균, 항피부암 활성 등이 보고되었다. 결론: 이 연구를 통해 베트남산 A. crassna 외의 4개 산지별로 품질에 있어서 휘발성 성분 조성에서 현저한 차이를 확인하였다. 침향은 그 자체가 고유한 향기를 가지면서 피부 건강에 유용한 활성을 가지는sesquiterpene 성분을 포함하고 있으므로, 향후 천연 화장품 원료로 활용하여 고부가가치를 가지는 기능성 화장품으로 개발이 기대된다.
Abstract
Purpose: The objective of this study was to evaluate the quality of five different types of agarwood from Vietnam and 4 other areas and analyze the volatile chemical components by gas chromatography mass spectrometry (GC-MS). We attempted to identify the ingredients that have previously been reported to have skin health benefits, and reviewed their potential future use as raw materials for natural cosmetics. Methods: The five sources of Aquilaria crassna (A. crassna ) were from Vietnamese, Indonesian, Malaysian, Myanmar, and Cambodian agarwoods. The volatile chemical components of each agarwood were analyzed by GC-MS. The Vietnamese agarwood was selected as a standard by identifying A. crassna through DNA analysis. Results: GC-MS analysis revealed that ‘sesquiterpene’ was contained in all the agarwood samples. The four sesquiterpene components, italicene ether, epi-γ-eudesmol, δ-guaiene, and α-agarofuran were commonly detected in all agarwood samples. Eight simple volatile aromatic compound components (1-octanol, 4-(4-methoxyphenyl)-2-butanone, 4-phenyl-2-butanone, benzaldehyde, ethylbenzene, nonanal, octanal, and 2-ethyl-1-hexanol) were commonly detected. The sesquiterpene components, α-agarofuran, β-selinene, α-curcumene, and α-santalol have been reported to have anti-inflammatory, antioxidant, antibacterial, and anti-skin cancer properties, respectively. Conclusion: This study demonstrated a substantial difference in the quality of the volatile component composition in each of the four source areas other than A. crassna from Vietnam. Agarwood contains sesquiterpene, which has a unique fragrance and is beneficial for skin health, and it is expected to be utilized as a raw material for natural cosmetics and developed in the future as a functional cosmetic with high added value.
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